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- Abasic phosphoramidite
Abasic phosphoramidite
| Cat. # | Quantity | Price | Lead time | |
|---|---|---|---|---|
| 3009-1g | 1 g | 990.00$
|
Cleavage of the N-glycosyl bond between a base and its 2-deoxyribose moiety in DNA generates an apurinic/apyrimidinic (so-called abasic) site. This phenomenon, which is referred to as depurination or depyrimidination occurs spontaneously under physiological conditions.
Phosphoramidites are modified nucleosides that are used in DNA and oligonucleotide synthesis. Abasic phosphoramidite replicates the loss of base pairing ability by a nucleotide. This modification can be useful when examining DNA damage and repair.
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