标签： Rantes人类重组CHM-328

Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. Rantes has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer cells to form CHAK cells. Rantes is also an HIV-suppressive factor released from CD8+ T cells. The Rantes chemokine has been localized to chromosome 17 in humans.

受激活、正常 T 细胞表达和分泌或 RANTES 的调节是一种 8 kDa 蛋白质，归类为趋化细胞因子或趋化因子。 Rantes 最近更名为 CCL5。 RANTES 对 T 细胞、嗜酸性粒细胞和嗜碱性粒细胞具有趋化作用，并在将白细胞募集到炎症部位方面发挥积极作用。 在 T 细胞释放的特定细胞因子的帮助下，RANTES 还诱导某些自然杀伤细胞的增殖和活化，形成 CHAK 细胞。 Rantes 也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。 Rantes 趋化因子已定位于人类的 17 号染色体。

Rantes Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7809.2 Dalton.
The Rantes is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Rantes Human Recombinant 是一种单一的非糖基化多肽链，含有 68 个氨基酸，分子量为 7809.2 道尔顿。
Rantes 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2µm filtered concentrated solution in 50mM NaAc, pH 5.0, 100mM NaCl.

It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rantes should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS.

The Rantes activity is determined by the chemoattract of human blood monocytes at a concentration between 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.