标签： ProSpec-TRAIL Human (114-281 a.a.) Active

Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL, Apo-2 ligand, Apo-2L, CD253 antigen, TL2, APO2L, TNFSF10.

TNF-related apoptosis-inducing ligand is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.
In humans, the gene that encodes for TRAIL is located at chromosome 3q26.
TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.

TNF相关的凋亡诱导配体是诱导细胞凋亡的配体分子。 它是一种 II 型跨膜蛋白，与肿瘤坏死因子家族的其他成员具有同源性。
在人类中，编码 TRAIL 的基因位于染色体 3q26。
TRAIL 与死亡受体 DR4 和 DR5 结合。 细胞凋亡过程是 caspase-8 依赖性的。 这种蛋白质优先诱导转化细胞和肿瘤细胞凋亡，但似乎不会杀死正常细胞，尽管它在大多数正常组织中以显着水平表达。

Soluble TNF-related apoptosis-inducing ligand Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids and having a molecular mass of 19.6 kDa. The sTRAIL is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的可溶性 TNF 相关凋亡诱导配体 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 169 个氨基酸，分子量为 19.6 kDa。 sTRAIL 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered colorless liquid.

TRAIL protein solution containing 20mM Tris-HCl pH-7.5, 300mM NaCl, 0.1mM DTT & 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 95.0% as determined by -PAGE.

Measured in a cell cytotoxicity assay using Jurkat human T lymphocyte. The ED50 for this effect is less or equal to 1 ng/ml.

使用 Jurkat 人 T 淋巴细胞在细胞毒性试验中测量。 这种效应的 ED50 小于或等于 1 ng/ml。

MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNGELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWSKDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG.

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