标签： ProSpec-RELM b Human

Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2.

RELM-beta is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin , RELM-alfa , RELM-beta and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents.
RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant.
The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice.

RELM-beta 是最近发现的一个分泌蛋白家族的成员，该家族含有一个保守的富含半胱氨酸的 C 末端。 RELM 家族由抵抗素、RELM-α、RELM-β 和 RELM-γ 组成。 在人类中仅发现了抵抗素和 RELM-beta，而在啮齿动物中发现了所有四个 RELM 家族成员。
RELM-beta 似乎仅由肠杯状细胞以同源二聚体形式产生，并且可以在粪便中大量发现。 值得注意的是，在无菌小鼠进入自然环境后发生细菌定植之前，展示无菌肠道的无菌小鼠粪便中不含 RELM-β。 一些（但不是全部）结肠癌细胞系将 RELM-β 分泌到细胞培养上清液中。
RELM-beta 的生理功能尚不清楚。 高剂量的重组 RELM-beta 显示出高血糖作用，包括降低小鼠的葡萄糖处理和增加肝葡萄糖的产生。

RELM-b Human Recombinant produced in E.Coli is a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 19kDa.
RELM-b is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 RELM-b Human Recombinant 是一种二硫键连接的同型二聚体、非糖基化多肽链，含有 2 x 89 个氨基酸，总分子量为 19kDa。
RELM-b 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

RELM-b was lyophilized from a solution containing 0.1% Trifluoroacetic Acid .

It is recommended to reconstitute the lyophilized RELM-b in sterile 0.1% TFA not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized RELM-b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution RELM-b Human Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

MQCSLDSVMD KKIKDVLNSL EYSPSPISKK LSCASVKSQG RPSSCPAGMA VTGCACGYGC GSWDVQLETT CHCQCSVVDW TTARCCHLT.

Greater than 90.0% as determined by -PAGE.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.