标签： ProSpec-I TAC Mouse

C-X-C motif chemokine 11, I-TAC, Small-inducible cytokine B11, Cxcl11, Scyb11.

Chemokine ligand 11 is a small cytokine belonging to the CXC chemokinen family.  I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TACchemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells.The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

趋化因子配体 11 是属于 CXC 趋化因子家族的小细胞因子。 I-TAC在外周血白细胞、胰腺和肝脏中高表达，在胸腺、脾脏和肺中表达中等，在小肠、胎盘和前列腺中低表达。 CXCL11的基因表达受IFN-g和IFN-b强烈诱导，而受IFN-a弱诱导。 I-TAC趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用，引发其对靶细胞的影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 I-TAC 对活化的 T 细胞具有趋化性。CXCL11 基因与 CXC 趋化因子家族的许多其他成员一起位于人类第 4 号染色体上。