标签： ProSpec-HCC 1 Human

Small inducible cytokine A14, CCL14, Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1, NCC-2, chemokine ligand 14, CC-1, CC-3, CKb1, MCIF, SY14, HCC-1, HCC-3, SCYL2, SCYA14.

Chemokine ligand 14 is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is procesed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut. CCL13 activates monocytes, but does not induce their chemotaxis. Human CCL13 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.

趋化因子配体 14 是一种属于 CC 趋化因子家族的小细胞因子。 它也通常称为HCC-1。 它是作为一种蛋白质前体产生的，经过加工产生一种成熟的活性蛋白质，该蛋白质含有 74 个氨基酸，其氨基酸组成与 CCL3 和 CCL4 有 46% 的相同性。 这种趋化因子在各种组织中表达，包括脾脏、骨髓、肝脏、肌肉和肠道。 CCL13 激活单核细胞，但不诱导其趋化性。 人类 CCL13 位于属于 CC 家族的其他趋化因子簇内的 17 号染色体上。

HCC-1 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 72 amino acids and having a molecular mass of 8411 Dalton.
The HCC-1 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 HCC-1 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 72 个氨基酸，分子量为 8411 道尔顿。
HCC-1 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

The CCL14 protein was lyophilized with 20mM PBS pH-7.4 and 150mM NaCl.

It is recommended to reconstitute the lyophilized HCC-1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized HCC1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

TESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHS
VCTNPSDKWVQDYIKDMKEN.

The Biological activity is calculated by its ability to chemoattract Human monocytes at 5-20ng/ml corresponding to a Specific Activity of 50,000-200,000IU/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。