标签： ProSpec-GRO b Human

Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta.

Chemokine ligand 2 is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha , Growth-regulated protein beta and Gro oncogene-2 . CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.

趋化因子配体 2 是属于 CXC 趋化因子家族的一种小细胞因子，也称为巨噬细胞炎症蛋白 2-α、生长调节蛋白 β 和 Gro oncogene-2。 CXCL2 在氨基酸序列上与相关趋化因子 CXCL1 有 90% 相同。 这种趋化因子由单核细胞和巨噬细胞分泌，对多形核白细胞和造血干细胞具有趋化作用。 CXCL2 的基因位于人类 4 号染色体上的其他 CXC 趋化因子簇中。 CXCL2 通过与称为 CXCR2 的细胞表面趋化因子受体相互作用来动员细胞。

GRO-Beta Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7908 Dalton.
The CXCL2 is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

The protein was lyophilized with no additives.

It is recommended to reconstitute the lyophilized GRO-beta Human in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 CXCL2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CXCL2 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Leu-Ala-Thr.

The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.