标签： ProSpec-FAS Human His

CD95, CD-95, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95 antigen, FAS, APT1, FAS1, TNFRSF6, APO-1, FASTM, ALPS1A.

FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.

FAS/CD95是一种36kDa的跨膜I型受体，属于NF/NGF受体超家族。 在与其天然配体 CD95L 相互作用后，它是免疫系统细胞中的有效细胞凋亡诱导剂。 尽管 CD95/CD95L 系统可以在肿瘤消退中发挥作用，但肿瘤细胞似乎下调 CD95 表达，作为对 CD95L 诱导的 T 淋巴细胞和 NK 细胞杀伤的抗性机制。 Fas 抗原在各种细胞类型的表面表达，包括活化的 T 和 B 淋巴细胞以及 T 淋巴母细胞系。 CD95 也在免疫系统外的一组广泛的非转化细胞中表达。

Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-335 of Fas antigen. The recombinant CD95 is fused to C-terminal 6-histidine amino acids. The FAS antigen is purified by proprietary chromatographic techniques.

从大肠杆菌中纯化的重组 FAS 抗原/CD95 是单条非糖基化多肽链，含有 Fas 抗原的 157-335 位氨基酸。 重组 CD95 与 C 末端 6-组氨酸氨基酸融合。 FAS 抗原通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile liquid formulation.

10mM Sodium Phosphate, pH 8.0.

CD95 although stable at 10°C for 5 days, should be stored below -18°C.

Please prevent freeze-thaw cycles.

Greater than 95% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.