标签： ProSpec Endoglin Human His

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.

The Endoglin protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Endoglin has been found to be part of the TGF-beta1 receptor complex. Endoglin thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Endoglin expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.

Endoglin 是一种位于细胞表面的 I 型膜糖蛋白，是 TGF β 受体复合物的一部分。
Endoglin 蛋白由具有二硫键的 180 kDA 同源二聚体组成。 已在内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上发现内皮糖蛋白。 此外，已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。 因此，内皮糖蛋白可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。 除了 TGF-β 信号转导内皮糖蛋白可能还有其他功能。 据推测，内皮糖蛋白参与影响细胞形态和迁移的细胞骨架组织。 Endoglin 在心血管系统的发育和血管重塑中发挥作用。 内皮糖蛋白的表达在心脏发育过程中受到调节。 没有内皮糖蛋白基因的实验小鼠因心血管异常而死亡。