标签： ProSpec EBI3 Human

Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B.

EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4 t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4 t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.

EBI3 在对 Epstein-Barr 病毒感染作出反应的 B 淋巴细胞中具有诱导表达。 EBI3 编码一种属于造血素受体家族的分泌糖蛋白，并与 28 kDa 蛋白异二聚化形成 iIL-27。 EBI3 驱动幼稚 cd4 t 细胞的快速克隆扩增。 EBI3 与 IL-12 强烈协同作用以激活幼稚 cd4 t 细胞的 IFN-γ 产生。 EBI3 通过细胞因子受体 wsx-1/tccr 介导其生物学效应。

EBI3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 209 amino acids fragment having a molecular weight of 23.3kDa.
The EBI3 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 EBI3 Human Recombinant 是一个单一的、非糖基化的多肽链，包含 209 个氨基酸片段，分子量为 23.3kDa。
EBI3 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

EBI3 Human Recombinant was lyophilized from a solution containing 10mM Acetic Acid and 0.5% Mannitol.

It is recommended to reconstitute the lyophilized EBI3 in sterile 10mM Acetic acid not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 10mM 乙酸中复溶冻干的 EBI3，然后可以进一步稀释成其他水溶液。

Lyophilized EBI3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EBI3 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

冻干的 EBI3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，EBI3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 请防止冻融循环。

Greater than 90% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

RKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPVSF
IATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVL
NVTAVHPWGSSSSFVPFITEHIIKPDPPEGVRLSPLAERQLQ
VQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSF
ILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK.

Assay data for Human recombinant EBI3 is based upon qualitative binding to anti-EBI3 antibody.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.