标签： ProSpec CYT-954

Tumor Necrosis Factor Superfamily Member 8, Tumor Necrosis Factor Superfamily, Member 8, CD153 Antigen, CD30 Ligand, CD30LG, CD30-L, CD30L, Tumor Necrosis Factor Superfamily Member 8, Tumor Necrosis Factor Ligand 3A, CD30 Antigen Ligand, TNLG3A, CD153, Tumor necrosis factor ligand superfamily member 8, TNFSF8, CD30 ligand.

CD30 Ligand is a cytokine which is a member of the tumor necrosis factor ligand family. The TNFSF8 cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The employment of the TNFSF8 cytokine expressed on B cell surface has an inhibitory role in modulating Ig class switch. TNFSF8 enhances cell proliferation of some lymphoma cell lines, while inducing cell death and reducing cell proliferation of other lymphoma cell lines. The pleiotropic biological activities of the TNFSF8 cytokine on different CD30+ lymphoma cell lines has a pathophysiologic role in Hodgkin’s and some non-Hodgkin’s lymphomas.

CD30 配体是一种细胞因子，是肿瘤坏死因子配体家族的成员。 TNFSF8 细胞因子是 TNFRSF8/CD30 的配体，TNFRSF8/CD30 是细胞表面抗原，也是霍奇金淋巴瘤和相关血液恶性肿瘤的标志物。 B 细胞表面表达的 TNFSF8 细胞因子的使用在调节 Ig 类转换中具有抑制作用。 TNFSF8增强一些淋巴瘤细胞系的细胞增殖，同时诱导细胞死亡并减少其他淋巴瘤细胞系的细胞增殖。 TNFSF8 细胞因子对不同 CD30+ 淋巴瘤细胞系的多效生物学活性在霍奇金和一些非霍奇金淋巴瘤中具有病理生理作用。

TNFSF8 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 181 amino acids and having a molecular mass of 20.7kDa .
TNFSF8 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 TNFSF8 是单条糖基化多肽链，含有 181 个氨基酸，分子量为 20.7kDa。
TNFSF8 在 C 末端用 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile filtered colorless solution.

TNFSF8 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85% as determined by -PAGE.

ADPQRTDSIP NSPDNVPLKG GNCSEDLLCI LKRAPFKKSW AYLQVAKHLN KTKLSWNKDG ILHGVRYQDG NLVIQFPGLY FIICQLQFLV QCPNNSVDLK LELLINKHIK KQALVTVCES GMQTKHVYQN LSQFLLDYLQ VNTTISVNVD TFQYIDTSTF PLENVLSIFL YSNSDHHHHH H.

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