标签： ProSpec CYT-884

Otoraplin, Melanoma Inhibitory Activity-Like Protein, Fibrocyte-Derived Protein, FDP, MIAL1, MIAL, Melanoma inhibitory activity-like protein.

OTOR proteins is also known as fibrocyte-derived protein and Melanoma inhibitory activity-like . Otoraplin is a member of the melanoma-inhibiting activity gene family. Otoraplin is a secreted 16 kDa globular protein that is expressed in the inner ear by periotic mesenchyme and developing and mature fibrocytes. OTOR is highly homologous to MIA/cartilage-derived retinoic acid-sensitive protein , which is a cartilage-specific protein that is also expressed in malignant melanoma cells. The 111 amino acid mature human otoraplin contains 1 SH3 domain and a Tyr at position 50 that is reportedly sulfated. Otoraplin takes pasrt in the initiation of periotic mesenchyme chondrogenesis.
Otoraplin is secreted through the Golgi apparatus and plays a role in cartilage development and maintenance. A frequent polymorphism in the translation start codon of OTOR can abolish translation and may be associated with forms of deafness.

OTOR 蛋白也称为纤维细胞衍生蛋白和黑色素瘤抑制活性蛋白。 Otoraplin 是黑色素瘤抑制活性基因家族的成员。 Otoraplin 是一种分泌的 16 kDa 球状蛋白，在内耳中由周围间充质以及发育和成熟的纤维细胞表达。 OTOR 与 MIA/软骨衍生的视黄酸敏感蛋白高度同源，后者是一种软骨特异性蛋白，也在恶性黑色素瘤细胞中表达。 111 个氨基酸的成熟人 otoraplin 包含 1 个 SH3 结构域和据报道在 50 位被硫酸化的 Tyr。 Otoraplin 在启动 periotic 间充质软骨形成中发挥作用。
Otoraplin 通过高尔基体分泌，在软骨发育和维持中发挥作用。 OTOR 的翻译起始密码子中的频繁多态性可以消除翻译并可能与耳聋形式有关。

OTOR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids and having a molecular mass of 14.3kDa.

Escherichia Coli.

Sterile Filtered clear solution.

OTOR protein solution containing Phosphate buffered saline , 30% glycerol and 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 90% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSHMLASKK LCADDECVYT ISLASAQEDY NAPDCRFINV KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF PRNLVKEQRV YQEATKEVPT TDIDFFCE.

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