标签： ProSpec CYT-873

Twisted Gastrulation BMP Signaling Modulator 1, TSG, Twisted Gastrulation Homolog 1 , Twisted Gastrulation Protein Homolog 1, Twisted Gastrulation Homolog 1, TWSG1.

Twisted gastrulation Protein is a secreted, cysteine-rich protein which has a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG functions as an agonist for BMP signaling by controlling the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. TSG N-terminal domain binds BMP protein directly and displays BMP antagonist activity.

扭曲的原肠胚形成蛋白是一种分泌的富含半胱氨酸的蛋白质，它通过调节 BMP 信号传导在果蝇和非洲爪蟾的背侧/腹侧模式中发挥作用。 TSG 通过控制 BMP 拮抗剂 Chordin/Sog 的抑制作用和金属蛋白酶 xolloid/tolloid 的切割特性，充当 BMP 信号传导的激动剂。 TSG N 末端结构域直接结合 BMP 蛋白并显示 BMP 拮抗剂活性。

TWSG1 Human Recombinant produced in CHO is a single, glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass ranging from 35-43kDa on -PAGE due to glycosylation.
The TWSG1 is purified by proprietary chromatographic techniques.

在 CHO 中产生的 TWSG1 Human Recombinant 是单条糖基化多肽链，含有 198 个氨基酸，由于糖基化，-PAGE 上的分子量范围为 35-43kDa。
TWSG1 通过专有的色谱技术进行纯化。

CHO.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2µm filtered solution in PBS.

It is recommended to reconstitute the lyophilized TSG in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18M-cm H2O 中复溶冻干的 TSG，然后可以进一步稀释成其他水溶液。

Lyophilized TSG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TSG should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 TSG 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，TSG 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 95.0% as determined by -PAGE.

CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV HAPYSSDKEH MCTVVYFDDC MSIHQCKISC ESMGASKYRW FHNACCECIG PECIDYGSKT VKCMN CMF.

The ED₅₀, as measured by its ability to inhibit alkaline phosphatase production induced by rHuBMP-6 in mouse ATDC5 cells, is less than 16µg/ml.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。