标签： ProSpec CYT-807

Osteostat, TNFSF18, Activation-induced TNFR member Ligand, GITRL,TL6, AITRL, Glucocorticoid-induced TNF-related ligand, hGITRL, Tumor necrosis factor ligand superfamily member 18, MGC138237.

Osteostat is the cytokine that binds to TNFRSF18/AITR/GITR and is important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells after stimulation by lipopolysaccharides.
Osteostat protein is detectable in human microvascular EC and is highly up-regulated by IFN-alpha and IFN-beta. Osteostat inhibit differentiation of osteoclasts from monocytic precursor cells. Osteostat suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony-stimulating factorinduced receptor activator of NF-kappaB expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology.

Osteostat 是与 TNFRSF18/AITR/GITR 结合的细胞因子，对活化的 T 淋巴细胞和内皮细胞之间的相互作用很重要，并可调节外周组织中的 T 淋巴细胞存活。在脂多糖刺激后，Osteostat 在小肠、卵巢、睾丸、肾和内皮细胞中高水平表达。
Osteostat 蛋白可在人微血管 EC 中检测到，并且被 IFN-α 和 IFN-β 高度上调。 Osteostat 抑制破骨细胞从单核细胞前体细胞分化。 Osteostat 通过抑制巨噬细胞集落刺激因子诱导的破骨细胞前体细胞中 NF-kappaB 表达的受体激活剂来抑制破骨细胞生成的早期阶段。 Osteostat 不抑制单核细胞和树突细胞中脂多糖诱导的 RANK 表达，或 T 细胞中活化诱导的 RANK 表达。 Osteostat 是一种新的破骨细胞生成调节剂，证实了内皮在骨生理学中的主要作用。

AITRL Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15kDa.
AITRL is fused to a 15 amino acid T7-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 AITRL Human Recombinant 是一条单一的、非糖基化的多肽链，包含 134 个氨基酸，分子量为 15kDa。
AITRL 在 N 端与 15 个氨基酸的 T7 标签融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered colorless solution.

AITRL protein solution contains 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 90% as determined by -PAGE.

MASMTGGQQM GRGSHMAKFG PLPSKWQMAS SEPPCVNKVS DWKLEILQNG LYLIYGQVAP NANYNDVAPF EVRLYKNKDM IQTLTNKSKI QNVGGTYELH VGDTIDLIFN SEHQVLKNNT YWGIILLANP QFIS.

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