标签： ProSpec CYT-806

TNF-related apoptosis-inducing ligand is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.

In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.

TNF相关的凋亡诱导配体是诱导细胞凋亡的配体分子。 它是一种 II 型跨膜蛋白，与肿瘤坏死因子家族的其他成员具有同源性。
在人类中，编码 TRAIL 的基因位于染色体 3q26。 TRAIL 与死亡受体 DR4 和 DR5 结合。 细胞凋亡过程是 caspase-8 依赖性的。 这种蛋白质优先诱导转化细胞和肿瘤细胞凋亡，但似乎不会杀死正常细胞，尽管它在大多数正常组织中以显着水平表达。

The protein was lyophilized containing PBS, pH 7.4, and 3mM DTT.

Lyophilized TRAIL although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TRAIL recombinant should be stored at 4C between 2-7 days and for future use below -18C.

For long term storage it is recommended to add a carrier protein .

Please prevent freeze-thaw cycles.

冻干的 TRAIL 虽然在室温下可稳定保存 3 周，但应在 -18C 以下干燥储存。 重组后，TRAIL 重组体应在 4C 下储存 2-7 天，以备将来在 -18C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 95.0% as determined by:

Analysis by RP-HPLC.

Analysis by -PAGE.