标签： ProSpec CYT-598

BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen.

TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.

TNFRSF17 是 tnfsf13b/blys/baff 和 tnfsf13/april 的受体。 TNFRSF17 促进 b 细胞存活并在调节体液免疫中发挥作用。 TNFRSF17 激活 nf-kappa-b 和 jnk。 TNFRSF17 是 TNF 受体超家族的成员。 TNFRSF17 在成熟 B 淋巴细胞中表达，并参与 B 细胞发育和自身免疫反应。 TNFRSF17 特异性结合肿瘤 TNFSF13B/TALL-1/BAFF，导致 NF-kappaB 和 MAPK8/JNK 激活。 TNFRSF17 与多种 TRAF 家族成员结合，因此可转导细胞存活和增殖的信号。 TNFRSF17 是一种 III 型膜蛋白，具有 1 个胞外富含半胱氨酸的结构域。在 TNFRSF 中，它与 TACI 具有最高的同源性。 BCMA 和 TACI 均已显示与 TNF 配体超家族成员 APRIL 和 BAFF 结合。已在免疫器官中发现 BCMA 表达。 TNFRSF17 似乎定位于高尔基体隔室。已显示 BCMA 与 APRIL 或 BAFF 的结合可刺激外周血 B 细胞中 IgM 的产生并增加培养的 B 细胞的存活率。

TNFRSF17 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 5.3 kDa.
The TNFRSF17 is purified by standard chromatographic techniques.

在大肠杆菌中产生的 TNFRSF17 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 50 个氨基酸，分子量为 5.3 kDa。
TNFRSF17 通过标准色谱技术纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

1mg of TNFRSF17 Human contain 20mM sodium phosphate buffer, pH-7.4, and 130mM NaCl.

It is recommended to reconstitute the lyophilized TNFRSF17 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中重新配制冻干的 TNFRSF17，然后可以进一步稀释成其他水溶液。

Lyophilized TNFRSF17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNFRSF17 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 TNFRSF17 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后 TNFRSF17 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

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