标签： ProSpec CYT-458

Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RSTN, XCP1, RETN1, MGC126603, MGC126609.

Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins referred to as the RELM family, and is also described as ADSF or FIZZ3 . Mouse resistin is expressed as a 114 amino acid prepeptide; its hydrofobic Nterminal 20 amino acid signal peptide is cleaved before its secretion. Mouse resistin circulates in blood as a homodimeric protein consisting of two 94 amino acid polypeptides, which are disulfide-linked via Cys26.
Resistin may be an important link between obesity. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity. Steppan et al. have suggested that resistin suppressed the ability to stimulate glucose uptake. They have also suggested that resistin was present at elevated levels in blood of obese mice, and was down regulated by fasting and by antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severely suppressed in obesity.
Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.

抵抗素是 RSTN 基因的产物，是一种肽激素，属于称为 RELM 家族的富含半胱氨酸的分泌蛋白类，也被描述为 ADSF 或 FIZZ3。小鼠抵抗素表达为 114 个氨基酸的前肽；它的疏水性 N 末端 20 个氨基酸信号肽在其分泌之前被切割。小鼠抵抗素作为同源二聚体蛋白在血液中循环，该蛋白由两个 94 个氨基酸的多肽组成，它们通过 Cys26 二硫键连接。
抵抗素可能是肥胖之间的重要联系。由脂肪细胞特异性产生和分泌的小鼠抵抗素作用于骨骼肌肌细胞、肝细胞和脂肪细胞本身，从而降低它们的敏感性。 Steppan 等人。已经表明抵抗素抑制了刺激葡萄糖摄取的能力。他们还提出，肥胖小鼠血液中的抵抗素水平升高，并且通过禁食和抗糖尿病药物下调。另一方面，Way 等人发现抵抗素的表达在肥胖症中受到严重抑制。
其他研究表明，小鼠抵抗素在脂肪细胞分化期间增加，但它似乎也抑制脂肪生成。相反，人类脂肪形成分化可能与抵抗素基因表达的下调有关。

Resistin Rat Recombinant is manufactured with N-terminal fusion of His tag.
Resistin Rat Recombinant His-Tagged Fusion Protein is an 11.9 kDa protein containing 94 amino acid residues of the Resistin Rat and 16 additional amino acid residues – His Tag .

Resistin Rat Recombinant 是用 His 标签的 N 端融合制造的。
Resistin Rat Recombinant His-Tagged Fusion Protein 是一种 11.9 kDa 的蛋白质，含有 Resistin Rat 的 94 个氨基酸残基和 16 个额外的氨基酸残基 – His 标签。

Escherichia Coli.

Filtered White lyophilized powder.

Filtered and lyophilized from 0.5mg/ml in 20mM Tris pH 8.0.

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 产品不是无菌的！ 在用于细胞培养之前，请用适当的无菌过滤器过滤产品。

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

将冻干蛋白储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

Greater than 95% as determined by -PAGE.

MRGSHHHHHH GMASHMPSMS LCPMDEAISK KINQDFSSLL PAAMKNTVLH CWSVSSRGRL ASCPEGTTVT SCSCGSGCGS WDVREDTMCH CQCGSIDWTA ARCCTLRVGS.

Prospec’s products are furnished forLABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.