标签： ProSpec CYT-413

Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2.

RELM-beta is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin , RELM-alfa , RELM-beta and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents.
RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant.
The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice.

RELM-beta 是最近发现的一个分泌蛋白家族的成员，该家族含有一个保守的富含半胱氨酸的 C 末端。 RELM 家族由抵抗素、RELM-α、RELM-β 和 RELM-γ 组成。 在人类中仅发现了抵抗素和 RELM-beta，而在啮齿动物中发现了所有四个 RELM 家族成员。
RELM-beta 似乎仅由肠杯状细胞以同源二聚体形式产生，并且可以在粪便中大量发现。 值得注意的是，在无菌小鼠进入自然环境后发生细菌定植之前，展示无菌肠道的无菌小鼠粪便中不含 RELM-β。 一些（但不是全部）结肠癌细胞系将 RELM-β 分泌到细胞培养上清液中。
RELM-beta 的生理功能尚不清楚。 高剂量的重组 RELM-beta 显示出高血糖作用，包括降低小鼠的葡萄糖处理和增加肝葡萄糖的产生。

Mouse RELM-b Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 8.9kDa.
The Mouse RETNLB is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的小鼠 RELM-b 重组体是一种单体的、非糖基化的多肽链，含有 83 个氨基酸，分子量为 8.9kDa。
Mouse RETNLB 是通过专有的色谱技术纯化的。

Escherichia Coli.

Brownish lyophilized powder.

The protein was lyophilized from a concentrated protein solution containing 10mM Acetic Acid with 2:1 mannitol to protein.

Reconstitute at 0.1 mg/ml with sterile pyrogen free water.

Lyophilized RETNLB is stable at -20°C. After reconstitution the protein should be kept at all times at -20°C. It is recommended to add a carrier protein for long term storage.

冻干的RETNLB在-20°C下是稳定的。 重组后的蛋白质应始终保持在-20°C。 建议添加载体蛋白以进行长期储存。

Greater than 97% as determined by -PAGE.

MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA.

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