标签： ProSpec CYT-280

Acrp30, AdipoQ, GBP-28, APM-1, ACDC.

The adipose tissue exclusively expresses and secretes Adiponectin . Acrp30 is involved in various physiological processes such as energy homeostasis, insulin sensitivity, hormonal processes, fatty acid metabolism and obesity.
Adiponectin circulates in the plasma. Decreased levels of Adiponectin are associated with insulin resistance and hyperinsulinemia, as seen in people with obesity insulin resistance, and diabetes type 2, whose plasma levels of adiponectin are reduced.
The modular structure of Acrp30 is comprised of N-terminal collagenous domain followed by a C-terminal globular domain.
Acrp30 also acts as a significant negative regulator in hematopoiesis and immune systems; it may be involved in ending inflammatory responses through its inhibitory functions. Adiponectin inhibits endothelial NF-kappa-b signaling through a cAMP-dependent pathway, it also inhibits TNF-alpha- induced expression of endothelial adhesion molecules.

脂肪组织专门表达和分泌脂联素。 Acrp30 参与多种生理过程，例如能量稳态、胰岛素敏感性、激素过程、脂肪酸代谢和肥胖。
脂联素在血浆中循环。 脂联素水平降低与胰岛素抵抗和高胰岛素血症有关，如肥胖胰岛素抵抗和 2 型糖尿病患者的血浆脂联素水平降低。
Acrp30 的模块化结构由 N 端胶原结构域和 C 端球状结构域组成。
Acrp30 还在造血和免疫系统中充当重要的负调节剂； 它可能通过其抑制功能参与结束炎症反应。 脂联素通过 cAMP 依赖性途径抑制内皮 NF-kappa-b 信号传导，它还抑制 TNF-α 诱导的内皮粘附分子的表达。

The Adiponectin Human recombinant protein is a single, non-glycosilated polypeptide chain produced in E. coli, having a molecular weight of 25.1 kDa and containing 231 amino acids .

脂联素人重组蛋白是在大肠杆菌中产生的单一非糖基化多肽链，分子量为 25.1 kDa，含有 231 个氨基酸。

Escherichia Coli.

Sterile Filtered clear solution.

Acrp30 protein solution contains Phosphate buffered saline pH 7.4 and 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Acrp30 purity is greater than 90% as determined by -PAGE.

MGHDQETTTQGPGVLLPLPKGACTGWMAGIPGHPGHNGAPGRDGRDGTPGE
KGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSV
GLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKD
VKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGE
RNGLYADNDNDSTFTGFLLYHDTN.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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