标签： ProSpec CYT-190

BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen.

TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.

TNFRSF17 是 tnfsf13b/blys/baff 和 tnfsf13/april 的受体。 TNFRSF17 促进 b 细胞存活并在调节体液免疫中发挥作用。 TNFRSF17 激活 nf-kappa-b 和 jnk。 TNFRSF17 是 TNF 受体超家族的成员。 TNFRSF17 在成熟 B 淋巴细胞中表达，并参与 B 细胞发育和自身免疫反应。 TNFRSF17 特异性结合肿瘤 TNFSF13B/TALL-1/BAFF，导致 NF-kappaB 和 MAPK8/JNK 激活。 TNFRSF17 与多种 TRAF 家族成员结合，因此可转导细胞存活和增殖的信号。 TNFRSF17 是一种 III 型膜蛋白，具有 1 个胞外富含半胱氨酸的结构域。在 TNFRSF 中，它与 TACI 具有最高的同源性。 BCMA 和 TACI 均已显示与 TNF 配体超家族成员 APRIL 和 BAFF 结合。已在免疫器官中发现 BCMA 表达。 TNFRSF17 似乎定位于高尔基体隔室。已显示 BCMA 与 APRIL 或 BAFF 的结合可刺激外周血 B 细胞中 IgM 的产生并增加培养的 B 细胞的存活率。

TNFRSF17 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 14.1kDa.
TNFRSF17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 TNFRSF17 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 130 个氨基酸，分子量为 14.1kDa。
TNFRSF17 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered colorless liquid.

TNFRSF17 protein solution containing 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 90.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSRKINSEP LKDEFKNTGS GLLGMANIDL EKSRTGDEII LPRGLEYTVE ECTCEDCIKS KPKVDSDHCF PLPAMEEGAT ILVTTKTNDY CKSLPAALSA TEIEKSISAR.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.