标签： ProSpec CYT-1179

Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, Txgp1, Tnfrsf4, tax-transcriptionally activated glycoprotein 1 receptor, TXGP1L, ACT35, Txgp, Ly-70, ACT3, OX4, CD134.

TNFRSF4, also known as TNF Receptor Superfamily Member 4, is a T cell co-stimulatory molecule which belongs to the TNF receptor superfamily. TNFRSF4 coordinates with other co-stimulatory substances such as CD28, CD40, CD30, CD27 and 4-1BB to control the activation of the immune response. TNFRSF4 takes a vital part in antigen-specific T cell expansion as well as survival. TNFRSF4 is up-regulated on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. In addition, TNFRSF4 regulates cytokine production from T cells, antigen presenting cells, natural killer cells and natural killer cells. TNFRSF4 regulates cytokine receptor signaling.

TNFRSF4，也称为TNF受体超家族成员4，是属于TNF受体超家族的T细胞共刺激分子。 TNFRSF4 与其他共刺激物质如 CD28、CD40、CD30、CD27 和 4-1BB 协调以控制免疫反应的激活。 TNFRSF4 在抗原特异性 T 细胞扩增和存活中起着至关重要的作用。 在抗原呈递细胞与 TCR 结合以及 CD40-CD40 配体和 CD28-B7 共同刺激后，TNFRSF4 在 CD4+ 和 CD8+ T 细胞上上调。 此外，TNFRSF4 调节 T 细胞、抗原呈递细胞、自然杀伤细胞和自然杀伤细胞的细胞因子产生。 TNFRSF4 调节细胞因子受体信号。

TNFRSF4 Mouse Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain containing 435 amino acids and having a molecular mass of 48.6kDa.
TNFRSF4 is fused to a 243 amino acid hIgG-His tag at C-terminus and purified by proprietary chromatographic techniques.

在 HEK293 细胞中产生的 TNFRSF4 Mouse Recombinant 是一条糖基化多肽链，包含 435 个氨基酸，分子量为 48.6kDa。
TNFRSF4 在 C 末端与 243 个氨基酸的 hIgG-His 标签融合，并通过专有色谱技术进行纯化。

HEK293 cells.

Sterile Filtered colorless solution.

TNFRSF4 protein contains Phosphate-Buffered Saline and 10% glycerol.

Greater than 95.0% as determined by -PAGE. 

DGSMVTARRL NCVKHTYPSG HKCCRECQPG HGMVSRCDHT RDTLCHPCET GFYNEAVNYD TCKQCTQCNH RSGSELKQNC TPTQDTVCRC RPGTQPRQDS GYKLGVDCVP CPPGHFSPGN NQACKPWTNC TLSGKQTRHP ALDAVCE DRSLLATLLW ETQRPTFRPT TVQSTTVWPR TSELPSPPTL VTPEGPLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH

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