FAS Human, Sf9
CYT-1153
2µg
10µg
1mg
Catalogue number
CYT-1153
Synonyms
Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6.
Introduction
FAS or tumor necrosis factor receptor superfamily member 6 or TNFRSF6, is part of the death receptor family, which is part of the TNF receptor protein family. TNFRSF6 has a crucial part in regulating viral infections. FAS protein can be found in almost all cell types, when its cognate ligand can be found in activated T cells, NK cells & dendritic cells. The regulating protein of FasL & TRAIL on HCMV-infected dendritic enhances direct destruction of activated T lymphocytes. furthermore, subvertneutrophil function in HCMV retinitis can occur when FasL is activated in HCMV infected retinal pigment epithelial cells.
FAS或肿瘤坏死因子受体超家族成员6或TNFRSF6,是死亡受体家族的一部分,它是TNF受体蛋白家族的一部分。 TNFRSF6 在调节病毒感染中起着至关重要的作用。 FAS 蛋白几乎可以在所有细胞类型中找到,而它的同源配体可以在活化的 T 细胞、NK 细胞和树突状细胞中找到。 HCMV 感染树突上的 FasL 和 TRAIL 调节蛋白增强了活化 T 淋巴细胞的直接破坏。 此外,当在 HCMV 感染的视网膜色素上皮细胞中激活 FasL 时,可能会发生 HCMV 视网膜炎中的亚中性粒细胞功能。
Description
FAS Human Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 156 amino acids and having a molecular mass of 17.7KDa.
FAS is fused to a 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
在杆状病毒中产生的 FAS Human Recombinant 是单条糖基化多肽链,包含 156 个氨基酸,分子量为 17.7KDa。
FAS 在 C 端与 8 个氨基酸的 His-Tag 融合,并通过专有色谱技术进行纯化。
Source
Sf9, Baculovirus cells.
Physical Appearance
Formulation
FAS protein contains 10% glycerol and Phosphate-Buffered Saline .
Stability
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
对于长期储存,建议添加载体蛋白。
避免多次冻融循环。
Purity
Greater than 95.0% as determined by -PAGE.
Amino acid sequence
QVTDINSKGL ELRKTVTTVE TQNLEGLHHD GQFCHKPCPP GERKARDCTV NGDEPDCVPC QEGKEYTDKA HFSSKCRRCR LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSTVCEHCDP CTKCEHGIIK ECTLTSNTKC KEEGSRSNLE HHHHHH
Usage
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