标签： ProSpec CYT-1084

WNT1 Inducible Signaling Pathway Protein 1, CCN Family Member 4, CCN4, Wnt-1 Inducible, Signaling Pathway Protein 1, WNT1 Induced Secreted Protein 1, Wnt-1-Induced Secreted Protein, CTC-458A3.8, WISP1tc, WISP1c, WISP1i, WISP-1, WISP1.

WISP1 is a part of a family of cysteine-rich, glycosylated signaling proteins that mediate varied developmental processes. WISP1 is a Downstream regulator in the Wnt/Frizzled-signaling pathway and is linked with cell survival.WISP1weakens p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X protein.

WISP1 是富含半胱氨酸的糖基化信号蛋白家族的一部分，可介导不同的发育过程。 WISP1 是 Wnt/Frizzled 信号通路的下游调节因子，与细胞存活有关。WISP1 通过激活 AKT 激酶减弱 p53 介导的细胞凋亡以响应 DNA 损伤，并上调抗凋亡 Bcl-X 蛋白。

WISP1 Human Recombinant produced in Mouse myeloma cell line is a single, glycosylated polypeptide chain containing 355 amino acids , having a molecular mass of 39.3kDa and fused to a 10 aa His Tag.

The WISP1 is purified by proprietary chromatographic techniques.

在小鼠骨髓瘤细胞系中产生的 WISP1 Human Recombinant 是一条含有 355 个氨基酸的糖基化多肽链，分子量为 39.3kDa，并与 10 个氨基酸的 His 标签融合。

WISP1 通过专有的色谱技术进行纯化。

HEK293 Cells.

Sterile Filtered White lyophilized powder.

WISP1 protein was lyophilized from a 0.2µm filtered solution in PBS.

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Greater than 95.0% as determined by -PAGE. 

TALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRG

LYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRR

VSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCW

PEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQC

PDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIANHHHHHHHHHH.

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