标签： ProSpec CYT-1039

TNFRSF4, TNF Receptor Superfamily Member 4, TAX Transcriptionally-Activated Glycoprotein 1 Receptor, OX40L Receptor, ACT35 Antigen, CD134 Antigen, TXGP1L, Tax-Transcriptionally Activated Glycoprotein 1 Receptor, Tumor Necrosis Factor Receptor Superfamily, Member 4, Tumor Necrosis Factor Receptor Superfamily Member 4 , Lymphoid Activation Antigene ACT35,  OX40 Cell Surface Antigen, OX40 Homologue , ATC35 Antigen, OX40 Antigen , ACT35, CD134, IMD16, OX40.

TNFRSF4, also known as TNF Receptor Superfamily Member 4, is a T cell co-stimulatory molecule which belongs to the TNF receptor superfamily. TNFRSF4 coordinates with other co-stimulatory substances such as CD28, CD40, CD30, CD27 and 4-1BB to control the activation of the immune response. TNFRSF4 takes a vital part in antigen-specific T cell expansion as well as survival. TNFRSF4 is up-regulated on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. In addition, TNFRSF4 regulates cytokine production from T cells, antigen presenting cells, natural killer cells and natural killer cells. TNFRSF4 regulates cytokine receptor signaling.

TNFRSF4，也称为TNF受体超家族成员4，是属于TNF受体超家族的T细胞共刺激分子。 TNFRSF4 与其他共刺激物质如 CD28、CD40、CD30、CD27 和 4-1BB 协调以控制免疫反应的激活。 TNFRSF4 在抗原特异性 T 细胞扩增和存活中起着至关重要的作用。 在抗原呈递细胞与 TCR 结合以及 CD40-CD40 配体和 CD28-B7 共同刺激后，TNFRSF4 在 CD4+ 和 CD8+ T 细胞上上调。 此外，TNFRSF4 调节 T 细胞、抗原呈递细胞、自然杀伤细胞和自然杀伤细胞的细胞因子产生。 TNFRSF4 调节细胞因子受体信号。

TNFRSF4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 425 amino acids and having a molecular mass of 46.9Da. . TNFRSF4 is expressed with a 239 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 TNFRSF4 是单条糖基化多肽链，含有 425 个氨基酸，分子量为 46.9Da。 . TNFRSF4 在 C 末端以 239 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile Filtered colorless solution.

TNFRSF4 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

Greater than 90.0% as determined by -PAGE.

Measured by its binding ability in a functional ELISA with mouse OX40 Ligand/TNFSF4 The ED50 range ≤ 0.15 ug/ml.

LHCVGDTYPS NDRCCHECRP GNGMVSRCSR SQNTVCRPCG PGFYNDVVSS KPCKPCTWCN LRSGSERKQL CTATQDTVCR CRAGTQPLDS YKPGVDCAPC PPGHFSPGDN QACKPWTNCT LAGKHTLQPA SNSSDAICED RDPPATQPQE TQGPPARPIT VQPTEAWPRT SQGPSTRPVE VPGGRALEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH

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