标签： ProSpec CYT-029

FST, FS, Activin-binding protein.

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone .

卵泡抑素是一种单链性腺蛋白，可特异性抑制促卵泡激素的释放。 单个 FST 基因编码两种同种型，FST317 和 FST344，分别含有 317 和 344 个氨基酸，由前体 mRNA 的可变剪接产生。 在一项研究中，测试了 37 个候选基因与 150 个家庭的多囊卵巢综合征或高雄激素血症的关联和关联，发现了 PCOS 和卵泡抑素之间关联的证据。 卵泡抑素直接与激活素结合并作为激活素拮抗剂发挥作用。 垂体促卵泡激素的生物合成和分泌的特异性抑制剂。

FST His Protein is 36.0 kDa protein containing 325 amino acid residues of the FST His and the 10 aa N-Terminal His-tag.

E. coli.

FST His Tag was filtered and lyophilized from 0.5mg/ml supplied in 20mM TRIS and 20mM NaCl, pH 7.5.

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 产品不是无菌的！ 在用于细胞培养之前，请用适当的无菌过滤器过滤产品。

Store lyophilized FST His at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted FST His can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

将冻干的 FST His 储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重构的 FST His 可在 4°C 下储存一段有限的时间； 在 4°C 下两周后它没有显示任何变化。

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ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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