标签： ProSpec-CXCL17 Rat/CHM-281

Protein Cxcl17, Cxcl17, RGD1304717, C-X-C motif chemokine 17, VEGF co-regulated chemokine 1, Vcc1, VCC-1.

树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。 CXCL17 诱导静止的、但不是 LPS 激活的外周血单核细胞和树突状细胞的趋化性，并且它还特异性地结合这些细胞。 当体外诱导形成管时，内皮细胞中CXCL17的表达增加。 在血管生成中起作用的CXCL17、CXCL1/GRO和CXCL8/IL8在原发性肺、乳腺和食管肿瘤中与VEGF的表达显着相关。 因此，CXCL17被认为在肿瘤血管生成中起作用。 成熟的大鼠 CXCL17 分别与小鼠、人 CXCL17 共享 82%、71% 的氨基酸序列同一性。

CXCL17 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 97 amino acids and having a molecular mass of 11.5kDa.
The CXCL17 is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

CXCL17 protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, 300mM NaCl, pH 7.4.

It is recommended to reconstitute the lyophilized CXCL17 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized CXCL17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

SPNQEVARHH GDQHQAPRRW LWEGGQECDC KDWSLRVSKR KTTAVLEPPR KQCPCDHVKG SEKKNRRQKH HRKSQRPSRT CQQFLKRCQL ASFTLPL.

Measured by its ability to induce VEGF expression in mouse endothelial cells. The ED₅₀ for this effect is typically 1-5 µg/ml.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.