标签： ProSpec-CXCL17 Human

Dcip1, DMC, MGC138300, UNQ473, VCC-1, VCC1, VEGF coregulated chemokine 1, C-X-C motif chemokine 17, Dendritic cell and monocyte chemokine-like protein.

树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。 CXCL17 诱导静止的、但不是 LPS 激活的外周血单核细胞和树突状细胞的趋化性，并且它还特异性地结合这些细胞。 当体外诱导形成管时，内皮细胞中CXCL17的表达增加。 在血管生成中起作用的CXCL17、CXCL1/GRO和CXCL8/IL8在原发性肺、乳腺和食管肿瘤中与VEGF的表达显着相关。 因此，CXCL17被认为在肿瘤血管生成中起作用。 成熟的大鼠 CXCL17 分别与小鼠、人 CXCL17 共享 82%、71% 的氨基酸序列同一性。

CXCL17 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.7kDa.CXCL17 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered clear solution.

CXCL17 protein solution contains 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.