BMP 5 Human
Bone Morphogenetic protein-5 Human Recombinant
CYT-660
ProSpec-BMP 5 Human/CYT-660 5µg
ProSpec-BMP 5 Human/CYT-660 20µg
ProSpec-BMP 5 Human/CYT-660 1mg
Catalogue number
CYT-660
Synonyms
Bone morphogenetic protein 5, BMP-5, BMP5, MGC34244.
Introduction
BMP5 belongs to the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. This superfamily is comprised of large families of growth and differentiation factors. Bone morphogenetic proteins were initially identified by their ability of demineralizing bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. It was shown that BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal ligament cells. The BMP5 protein is expressed in normal synovial tissue and reduced in osteoarthritis and rheumatoid arthritis. BMP5 may have a role in certain cancers given that it is differentially regulated during the formation of different tumors.
BMP5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. It was shown that BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal ligament cells. The BMP5 protein is expressed in normal synovial tissue and reduced in osteoarthritis and rheumatoid arthritis. BMP5 may have a role in certain cancers given that it is differentially regulated during the formation of different tumors.
BMP5 属于骨形态发生蛋白家族，它是转化生长因子-β 超家族的一部分。 这个超家族由生长和分化因子的大家族组成。 骨形态发生蛋白最初是通过它们使骨提取物脱矿质以在体内在骨骼外部位诱导软骨内成骨的能力来鉴定的。
BMP5 是小梁网和视神经乳头内必需的信号分子，可能在青光眼发病机制中发挥潜在作用。 结果表明，BMP-5 增加了人牙周膜细胞中骨桥蛋白、BMP-2、碱性磷酸酶和核心结合因子 α1 mRNA 的水平。 BMP5 蛋白在正常滑膜组织中表达，在骨关节炎和类风湿性关节炎中减少。 BMP5 可能在某些癌症中发挥作用，因为它在不同肿瘤的形成过程中受到不同的调节。
BMP5 是小梁网和视神经乳头内必需的信号分子，可能在青光眼发病机制中发挥潜在作用。 结果表明，BMP-5 增加了人牙周膜细胞中骨桥蛋白、BMP-2、碱性磷酸酶和核心结合因子 α1 mRNA 的水平。 BMP5 蛋白在正常滑膜组织中表达，在骨关节炎和类风湿性关节炎中减少。 BMP5 可能在某些癌症中发挥作用，因为它在不同肿瘤的形成过程中受到不同的调节。
Description
BMP-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids and having a total molecular mass of 15.7 kDa.
BMP-5 is purified by proprietary chromatographic techniques.
BMP-5 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 BMP-5 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 139 个氨基酸，总分子量为 15.7 kDa。
BMP-5 通过专有的色谱技术进行纯化。
BMP-5 通过专有的色谱技术进行纯化。
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The BMP-5 solution contains 10mM Sodium Citrate buffer and 10% Glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。
Purity
Greater than 95.0% as determined by -PAGE.
Amino acid sequence
MAANKRKNQN RNKSSSHQDS SRMSSVGDYN TSEQKQACKK HELYVSFRDL GWQDWIIAPE GYAAFYCDGE CSFPLNAHMN ATNHAIVQTL VHLMFPDHVP KPCCAPTKLN AISVLYFDDS SNVILKKYRN MVVRSCGCH.
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。