标签： ProSpec ANGPTL3 (17-460) Human

Angiopoietin Like 3, Angiopoietin 5, ANGPT5, ANG-5, Angiopoietin-Related Protein 3 , Angiopoietin-Like Protein 3, Angiopoietin-Like 3, Angiopoietin-5, FHBL2, ANL3.

血管生成素样 3、血管生成素 5、ANGPT5、ANG-5、血管生成素相关蛋白 3、血管生成素样蛋白 3、血管生成素样 3、血管生成素-5、FHBL2、ANL3。

ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins . Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain and not the C-terminal fibrinogen-like domain increased the plasma triglyceride levels in mice.

ANGPTL3和ANGPTL4是主要由肝脏分泌和表达的血管生成素样蛋白，它们的作用是通过抑制富含甘油三酯的脂蛋白的脂解来调节甘油三酯代谢。 如实验数据所示，在不同的营养状态期间，循环甘油三酯的水平由 Angptl3 和 Angptl4 通过对脂蛋白脂肪酶的差异抑制来调节。 ANGPTL3 的分子结构与血管生成素相似。 使用人血管生成素 5 的缺失突变体来证明 N 端结构域而不是 C 端纤维蛋白原样结构域增加了小鼠血浆甘油三酯水平。

Sf9, Baculovirus cells.

Sterile Filtered colorless solution.

ANGPTL3 protein solution contains Buffered Saline ,30% glycerol And 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

Greater than 90.0% as determined by -PAGE.

ADPSRIDQDN SSFDSLSPEP KSRFAMLDDV KILANGLLQL GHGLKDFVHK TKGQINDIFQ KLNIFDQSFY DLSLQTSEIK EEEKELRRTT YKLQVKNEEV KNMSLELNSK LESLLEEKIL LQQKVKYLEE QLTNLIQNQP ETPEHPEVTS LKTFVEKQDN SIKDLLQTVE DQYKQLNQQH SQIKEIENQL RRTSIQEPTE ISLSSKPRAP RTTPFLQLNE IRNVKHDGIP AECTTIYNRG EHTSGMYAIR PSNSQVFHVY CDVISGSPWT LIQHRIDGSQ NFNETWENYK YGFGRLDGEF WLGLEKIYSI VKQSNYVLRI ELEDWKDNKH YIEYSFYLGN HETNYTLHLV AITGNVPNAI PENKDLVFST WDHKAKGHFN CPEGYSGGWW WHDECGENNL NGKYNKPRAK SKPERRRGLS WKSQNGRLYS IKSTKMLIHP TDSESFEHHH HHH.

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