标签： ProSpec 细胞因子

ProSpec-APOM Human, HEK/CYT-026

ProSpec APOM Human HEK,ProSpec CYT-026,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,G3a, HSPC336, NG20, Apolipoprotein M, APOM, Apo-M, MGC22400.

APOM Human, HEK

Apolipoprotein-M Human Recombinant, HEK
CYT-026
ProSpec-APOM Human, HEK/CYT-026 2µg
ProSpec-APOM Human, HEK/CYT-026 10µg
ProSpec-APOM Human, HEK/CYT-026 1mg

Catalogue number

CYT-026

Synonyms

G3a, HSPC336, NG20, Apolipoprotein M, APOM, Apo-M, MGC22400.

Introduction

APOM is belongs to the lipocalin protein family and is associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. APOM is secreted through the plasma membrane but remains membrane-bound, where it takes part in lipid transport.
APOM 属于脂质运载蛋白家族，与高密度脂蛋白有关，在较小程度上与低密度脂蛋白和富含甘油三酯的脂蛋白有关。 APOM 通过质膜分泌，但仍与膜结合，参与脂质转运。

Description

APOM HEK Human Recombinant Protein is 20 kDa protein containing 179 amino acid residues of the APOM Human and 13 additional amino acid residues of flag Tag.
APOM HEK Human Recombinant Protein 是一种 20 kDa 的蛋白质，含有 APOM Human 的 179 个氨基酸残基和 flag Tag 的 13 个附加氨基酸残基。

Source

HEK293.

Physical Appearance

White lyophilized powder.

Formulation

APOM Human was filtered and lyophilized from 0.5 mg/ml supplied in 20mM TRIS and 50mM NaCl, pH 7.5.

Solubility

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.
建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 产品不是无菌的！ 在用于细胞培养之前，请用适当的无菌过滤器过滤产品。

Stability

Store lyophilized APOM Human at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted APOM Human can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
将冻干的 APOM Human 储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重构的 APOM Human 可以在 4°C 下储存一段有限的时间； 在 4°C 下两周后它没有显示任何变化。

Amino acid sequence

HVDYKDDDDK PAGCPEHSQL TTLGVDGKEF PEVHLGQWYF IAGAAPTKEE LATFDPVDNI VFNMAAGSAP MQLHLRATIR MKDGLCVPRK WIYHLTEGST DLRTEGRPDM KTELFSSSCP GGIMLNETGQ GYQRFLLYNR SPHPPEKCVE EFKSLTSCLD SKAFLLTPRN QEACELSNN

Applications

Cell culture and/or animal studies, ELISA and Western blotting.

Purity

Greater than 90% as determined by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • APOM Human

ProSpec-Clusterin/CYT-548

ProSpec Clusterin,ProSpec CYT-548,ProSpec Clusterin Rat,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Clusterin 也称为载脂蛋白 J，是一种 75-80 kD 二硫键连接的异二聚体蛋白，含有约 30% 的富含唾液酸的 N 连接碳水化合物，但也已鉴定出靶向细胞核的截短形式。

Clusterin

Human Clusterin
CYT-548
ProSpec-Clusterin/CYT-548 2µg
ProSpec-Clusterin/CYT-548 10µg
ProSpec-Clusterin/CYT-548 1mg

Catalogue number

CYT-548

Synonyms

CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, MGC24903, Clusterin, Apolipoprotein J, Apo-J.

Introduction

Clusterin also named Apolipoprotein J is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified.
The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices.
Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen.
It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition.
A genuine function of clusterin has not been defined. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced insults caused by degraded and misfolded protein precipitates.
Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
Clusterin 也称为载脂蛋白 J，是一种 75-80 kD 二硫键连接的异二聚体蛋白，含有约 30% 的富含唾液酸的 N 连接碳水化合物，但也已鉴定出靶向细胞核的截短形式。
前体多肽链被蛋白水解切割以去除 22-mer 分泌信号肽，随后在残基 227/228 之间生成 a 和 b 链。这些以反平行方式组装以产生异二聚体分子，其中富含半胱氨酸的中心通过五个二硫键连接，并且两侧是两个预测​​的卷曲螺旋α-螺旋和三个预测的两亲α-螺旋。
在广泛的物种中，clusterin 显示出高度的序列同源性，范围从 70% 到 80%。它几乎在大多数哺乳动物组织中普遍表达，可以在血浆、乳汁、尿液、脑脊液和精液中找到。
它能够与免疫球蛋白、脂质、肝素、细菌、补体成分、对氧磷酶、β淀粉样蛋白、瘦素等众多伙伴结合并形成复合物。凝聚素被赋予了过多的功能，例如吞噬细胞募集、聚集诱导、补体攻击预防、细胞凋亡抑制、膜重塑、脂质转运、激素转运和/或清除、基质金属蛋白酶抑制。
尚未定义 clusterin 的真正功能。一个诱人的假设说，凝聚素是一种细胞外伴侣蛋白，可保护细胞免受由降解和错误折叠的蛋白质沉淀物引起的应激损伤。
在包括癌症、器官再生、感染、阿尔茨海默病、色素性视网膜炎、心肌梗塞、肾小管损伤、自身免疫等在内的许多病理和临床相关情况下，Clusterin 的 mRNA 或蛋白质水平上调或下调。

Source

Plasma.

Physical Appearance

Filtered White lyophilized powder.

Formulation

Human native Clusterin was filtered and lyophilized from 0.5mg/ml in 0.1M phosphate buffer, 0.15M NaCl pH 7.5.

Solubility

It is recommended to add deionized H2O to prepare a working stock solution of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
建议加入去离子水配制 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 产品不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Stability

Store lyophilized Clusterin at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
将冻干的 Clusterin 储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

Purity

Greater than 95% as determined by PAGE.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • Clusterin Antibody
  • Clusterin Rat
  • Clusterin Human
  • Clusterin Canine
  • Clusterin Canine, HEK
  • Clusterin Human, Serum
  • Clusterin Mouse

ProSpec-Clusterin Canine, HEK/CYT-618

ProSpec Clusterin Canine, HEK,ProSpec CYT-618,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,在 HEK293 细胞中产生的 Clusterin Canine Recombinant 是一种糖基化的多肽链，含有 436 个氨基酸，分子量为 50.72 kDa。 该蛋白在 N 末端融合了 13 个氨基酸的 Flag 标签。

Clusterin Canine, HEK

Clusterin Canine Recombinant, HEK
CYT-618
2µg
10µg
1mg

Catalogue number

CYT-618

Synonyms

CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, MGC24903, Clusterin, Glycoprotein 80, Gp80, CLU.

Introduction

Clusterin mRNA and Clusterin protein are shown to increase with androgen treatment. Binding of clusterin to the LDL-Receptor plays a role in the pathogenesis of membranous glomerulonephritis. Clusterin is down regulated in CaP in association with matched benign controls. Clusterin is involved in cellular senescence and tumorigenesis. Clusterin is involved in photo-oxidative cell death pathway. Clusterin is a functional tumor marker for the diagnosis of pediatric large cell lymphoma. Clusterin is activated in low pH. Clusterin is involved in the inhibition of NF-kappaB signaling through stabilization of IkappaBs thus results in suppression of tumor cell motility. N-terminal deletion of clusterin is vital for its alterations of biogenesis in esophageal squamous cell carcinoma.
Clusterin mRNA 和 Clusterin 蛋白显示随着雄激素治疗而增加。 凝聚素与 LDL 受体的结合在膜性肾小球肾炎的发病机制中起作用。 与匹配的良性对照相关，Clusterin 在 CapP 中被下调。 凝聚素参与细胞衰老和肿瘤发生。 凝聚素参与光氧化细胞死亡途径。 Clusterin 是诊断小儿大细胞淋巴瘤的功能性肿瘤标志物。 凝聚素在低 pH 值下被激活。 Clusterin 通过稳定 IkappaB 参与抑制 NF-kappaB 信号传导，因此导致抑制肿瘤细胞运动。 簇蛋白的 N 末端缺失对其在食管鳞状细胞癌中的生物发生改变至关重要。

Description

Clusterin Canine Recombinant produced in HEK293 cells is a glycosylated, Polypeptide chain containing 436 amino acids and having a molecular mass of 50.72 kDa. The protein is fused with 13 amino acid Flag tag at N-Terminus.
The Apolipoprotein-J Canine is purified by proprietary chromatographic techniques.
在 HEK293 细胞中产生的 Clusterin Canine Recombinant 是一种糖基化的多肽链，含有 436 个氨基酸，分子量为 50.72 kDa。 该蛋白在 N 末端融合了 13 个氨基酸的 Flag 标签。
载脂蛋白-J Canine 通过专有的色谱技术进行纯化。

Source

Human Embryonic Kidney 293 Cells.

Physical Appearance

Filtered White lyophilized powder.

Formulation

Canine Clusterin was filtered and lyophilized from 0.5mg/ml solution containing 20mM Tris buffer and 20mM NaCl, pH 7.5.

Solubility

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.
建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 产品不是无菌的！ 在用于细胞培养之前，请用适当的无菌过滤器过滤产品。

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
将冻干蛋白储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

Purity

Greater than 95% as determined by PAGE.

Amino acid sequence

PGDYKDDDDK PAGDQAVSDT ELQEMSTEGS KYINKEIKNA LKGVKQIKTL IEQTNEERKS LLSNLEEAKK KKEDALNDTK DSETKLKASQ GVCNDTMMAL WEECKPCLKQ TCMKFYARVC RSGSGLVGHQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ THALDVMQDS FNRASSIMDE LFQDRFFTRE PQDTYHYSPF SLFQRRPFFN PKFRIARNII PFPRFQPLNF HDMFQPFFDM IHQAQQAMDV NLHRIPYHFP IEFPEEDNRT VCKEIRHNST GCLKMKDQCE KCQEILSVDC SSNNPAQVQL RQELSNSLQI AEKFTKLYDE LLQSYQEKMF NTSSLLKQLN EQFSWVSQLA NLTQSEDPFY LQVTTVGSQT NVPVGFT KVVVKLFDSD PITVMIPEAV SRNNPKFMET VAEKALQEYRQKHREE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines

Related Products

  • Clusterin
  • Clusterin Rat
  • Clusterin Canine
  • Clusterin Human
  • Clusterin Mouse

ProSpec-Clusterin Human, His/CYT-814

ProSpec Clusterin Human His,ProSpec CYT-814,ProSpec Clusterin Mouse,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,CLI, AAG4, APOJ, KUB1, SGP2, SGP-2, SP-40, TRPM2, TRPM-2, MGC24903, Clusterin, ging-associated gene 4 protein, Apolipoprotein J,Complement cytolysis inhibitor, Complement-associated protein SP-40,40, Ku70-binding protein 1, NA1/NA2, Testosterone-repressed prostate message 2, CLU.

Clusterin Human, His

Apolipoprotein-J Human Recombinant, His Tag
CYT-814
5µg
20µg
1mg

Catalogue number

CYT-814

Synonyms

CLI, AAG4, APOJ, KUB1, SGP2, SGP-2, SP-40, TRPM2, TRPM-2, MGC24903, Clusterin, ging-associated gene 4 protein, Apolipoprotein J,Complement cytolysis inhibitor, Complement-associated protein SP-40,40, Ku70-binding protein 1, NA1/NA2, Testosterone-repressed prostate message 2, CLU.
CLI、AAG4、APOJ、KUB1、SGP2、SGP-2、SP-40、TRPM2、TRPM-2、MGC24903、Clusterin、ging 相关基因 4 蛋白、载脂蛋白 J、补体细胞溶解抑制剂、补体相关蛋白 SP-40、 40，Ku70 结合蛋白 1，NA1/NA2，睾酮抑制的前列腺信息 2，CLU。

Introduction

Clusterin also named Apolipoprotein J is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified.
The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices.
Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen.
It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition.
A genuine function of clusterin has not been defined. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced insults caused by degraded and misfolded protein precipitates.
Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
Clusterin 也称为载脂蛋白 J，是一种 75-80 kD 二硫键连接的异二聚体蛋白，含有约 30% 的富含唾液酸的 N 连接碳水化合物，但也已鉴定出靶向细胞核的截短形式。
前体多肽链被蛋白水解切割以去除 22-mer 分泌信号肽，随后在残基 227/228 之间生成 a 和 b 链。这些以反平行方式组装以产生异二聚体分子，其中富含半胱氨酸的中心通过五个二硫键连接，并且两侧是两个预测​​的卷曲螺旋α-螺旋和三个预测的两亲α-螺旋。
在广泛的物种中，clusterin 显示出高度的序列同源性，范围从 70% 到 80%。它几乎在大多数哺乳动物组织中普遍表达，可以在血浆、乳汁、尿液、脑脊液和精液中找到。
它能够与免疫球蛋白、脂质、肝素、细菌、补体成分、对氧磷酶、β淀粉样蛋白、瘦素等众多伙伴结合并形成复合物。凝聚素被赋予了过多的功能，例如吞噬细胞募集、聚集诱导、补体攻击预防、细胞凋亡抑制、膜重塑、脂质转运、激素转运和/或清除、基质金属蛋白酶抑制。
尚未定义 clusterin 的真正功能。一个诱人的假设说，凝聚素是一种细胞外伴侣蛋白，可保护细胞免受由降解和错误折叠的蛋白质沉淀物引起的应激损伤。
在包括癌症、器官再生、感染、阿尔茨海默病、色素性视网膜炎、心肌梗塞、肾小管损伤、自身免疫等在内的许多病理和临床相关情况下，Clusterin 的 mRNA 或蛋白质水平上调或下调。

Description

Clusterin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 463 amino acids and having a molecular mass of 54.1kDa. Clusterin is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 Clusterin Human Recombinant 是一种单一的、非糖基化的多肽链，含有 463 个氨基酸，分子量为 54.1kDa。 Clusterin 在 N 末端与 36 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

Clusterin protein solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSDQTV SDNELQEMSN QGSKYVNKEI QNAVNGVKQI KTLIEKTNEE RKTLLSNLEE AKKKKEDALN ETRESETKLK ELPGVCNETM MALWEECKPC LKQTCMKFYA RVCRSGSGLV GRQLEEFLNQ SSPFYFWMNG DRIDSLLEND RQQTHMLDVM QDHFSRASSI IDELFQDRFF TREPQDTYHY LPFSLPHRRP HFFFPKSRIV RSLMPFSPYE PLNFHAMFQP FLEMIHEAQQ AMDIHFHSPA FQHPPTEFIR EGDDDRTVCR EIRHNSTGCL RMKDQCDKCR EILSVDCSTN NPSQAKLRRE LDESLQVAER LTRKYNELLK SYQWKMLNTS SLLEQLNEQF NWVSRLANLT QGEDQYYLRV TTVASHT DVPSGVTEVV VKLFDSDPIT VTVPVEVSRK NPKFMETVAE KALQEYRKKH REE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • Clusterin Mouse

ProSpec-BMP 5 Human/CYT-660,Bone Morphogenetic protein-5 Human Recombinant

ProSpec BMP 5 Human,ProSpec CYT-660,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,ProSpec-BMP 5 Human/CYT-660,在大肠杆菌中产生的 BMP-5 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 139 个氨基酸，总分子量为 15.7 kDa。
BMP-5 通过专有的色谱技术进行纯化。

BMP 5 Human

Bone Morphogenetic protein-5 Human Recombinant
CYT-660
ProSpec-BMP 5 Human/CYT-660 5µg
ProSpec-BMP 5 Human/CYT-660 20µg
ProSpec-BMP 5 Human/CYT-660 1mg

Catalogue number

CYT-660

Synonyms

Bone morphogenetic protein 5, BMP-5, BMP5, MGC34244.

Introduction

BMP5 belongs to the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. This superfamily is comprised of large families of growth and differentiation factors. Bone morphogenetic proteins were initially identified by their ability of demineralizing bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. It was shown that BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal ligament cells. The BMP5 protein is expressed in normal synovial tissue and reduced in osteoarthritis and rheumatoid arthritis. BMP5 may have a role in certain cancers given that it is differentially regulated during the formation of different tumors.
BMP5 属于骨形态发生蛋白家族，它是转化生长因子-β 超家族的一部分。 这个超家族由生长和分化因子的大家族组成。 骨形态发生蛋白最初是通过它们使骨提取物脱矿质以在体内在骨骼外部位诱导软骨内成骨的能力来鉴定的。
BMP5 是小梁网和视神经乳头内必需的信号分子，可能在青光眼发病机制中发挥潜在作用。 结果表明，BMP-5 增加了人牙周膜细胞中骨桥蛋白、BMP-2、碱性磷酸酶和核心结合因子 α1 mRNA 的水平。 BMP5 蛋白在正常滑膜组织中表达，在骨关节炎和类风湿性关节炎中减少。 BMP5 可能在某些癌症中发挥作用，因为它在不同肿瘤的形成过程中受到不同的调节。

Description

BMP-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids and having a total molecular mass of 15.7 kDa.
BMP-5 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 BMP-5 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 139 个氨基酸，总分子量为 15.7 kDa。
BMP-5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The BMP-5 solution contains 10mM Sodium Citrate buffer and 10% Glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MAANKRKNQN RNKSSSHQDS SRMSSVGDYN TSEQKQACKK HELYVSFRDL GWQDWIIAPE GYAAFYCDGE CSFPLNAHMN ATNHAIVQTL VHLMFPDHVP KPCCAPTKLN AISVLYFDDS SNVILKKYRN MVVRSCGCH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-GDF5 Human/CYT-442,Growth Differentiation Factor-5 Human Recombinant

ProSpec GDF5 Human,ProSpec CYT-442,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。

GDF5 Human

Growth Differentiation Factor-5 Human Recombinant
CYT-442
ProSpec-GDF5 Human/CYT-442 10µg
ProSpec-GDF5 Human/CYT-442 50µg
ProSpec-GDF5 Human/CYT-442 1mg

Catalogue number

CYT-442

Synonyms

Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14.

Introduction

GDF-5 is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

Description

Growth Differentiation Factor 5 Human Recombinant produced in E.Coli is a homodimer, non-glycosylated polypeptide chain containing 2 x 120 amino acids and having a total molecular mass of 27.4kDa. To enable bacterial expression the N-terminal sequence of Ala-Pro-Leu-Thr was replaced with a Lys.
GDF5 is purified by proprietary chromatographic techniques.

介绍

GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。 该家族的成员是胚胎和成人组织中细胞生长和分化的调节剂。 该基因的突变与Hunter-Thompson型肢端发育不良有关； 短指，C型； 和软骨发育不良，Grebe型。 这些关联证实基因产物在骨骼发育中发挥作用。

描述

在大肠杆菌中产生的生长分化因子 5 人重组体是一种同型二聚体、非糖基化多肽链，含有 2 x 120 个氨基酸，总分子量为 27.4kDa。 为了实现细菌表达，将 Ala-Pro-Leu-Thr 的 N 端序列替换为 Lys。
GDF5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized without any additives.

Solubility

It is recommended to reconstitute the lyophilized Growth Differentiation Factor-5 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议将冻干的生长分化因子 5 用不低于 100µg/ml 的无菌 18MΩ-cm H2O 复溶，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized Growth Differentiation Factor 5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Growth Differentiation Factor-5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干生长分化因子 5 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，生长分化因子 5 应在 4°C 下储存 2-7 天，并在 -18°C 以下供将来使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Biological Activity

GDF-5 activity as determined by the induction of alkaline phosphatase activity in ATDC5 cells is typically 10-20ng/ml.

Amino acid sequence

APSATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR.

Protein content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 1.15 as the extinction coefficient for a 0.1% solution. This value is calculated by the PC GENE computer analysis program of protein sequences .
2. Analysis by RP-HPLC, using a standard solution of GDF5 as a Reference Standard.
蛋白质定量通过两种独立的方法进行：
1. 280 nm 的紫外光谱，使用 1.15 的吸光度值作为 0.1% 溶液的消光系数。 该值是由 PC GENE 计算机蛋白质序列分析程序计算得出的。
2. 反相高效液相色谱分析，使用 GDF5 的标准溶液作为参考标准。

References

Title:Growth/differentiation Factor-5 Induces Osteogenic Differentiation of Human Ligamentum Flavum Cells through Activation of ERK1/2 and p38 MAPK.
Publication:Cell Physiol Biochem 2010;26:179-186
Link:http://content.karger.com/produktedb/produkte.asp?doi=320526

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

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  • GDF15 Human, His
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  • GDF3 Human
  • GDF5 Mouse, His

ProSpec-GDF5 Human, His/CYT-653,Growth differentiation factor 5 Human Recombinant, His Tag

ProSpec GDF5 Human His,CYT-653,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14.

GDF5 Human, His

Growth differentiation factor 5 Human Recombinant, His Tag
CYT-653
ProSpec-GDF5 Human, His/CYT-653 5µg
ProSpec-GDF5 Human, His/CYT-653 25µg
ProSpec-GDF5 Human, His/CYT-653 1mg

Catalogue number

CYT-653

Synonyms

Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14.

Introduction

GDF-5 is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。 该家族的成员是胚胎和成人组织中细胞生长和分化的调节剂。 该基因的突变与Hunter-Thompson型肢端发育不良有关； 短指，C型； 和软骨发育不良，Grebe型。 这些关联证实基因产物在骨骼发育中发挥作用。

Description

GDF5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids and having a total molecular mass of 15.8 kDa.
GDF5 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 GDF5 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 141 个氨基酸，总分子量为 15.8 kDa。
GDF5 在 N 末端与 20 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The GDF5 solution contains 10mM sodium citrate pH-3.5 and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • GDF5 Mouse
  • GDF5 Mouse, His
  • GDF5 Human

ProSpec-GDF5 Mouse/CYT-941,Growth and Differentiation factor 5 Mouse Recombinant

ProSpec GDF5 Mouse,ProSpec CYT-941,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。

GDF5 Mouse

Growth and Differentiation factor 5 Mouse Recombinant
CYT-941
ProSpec-GDF5 Mouse/CYT-941 10µg
ProSpec-GDF5 Mouse/CYT-941 50µg
ProSpec-GDF5 Mouse/CYT-941 1mg

Catalogue number

CYT-941

Synonyms

Bmp-14, Bp, GDF-5, Bone morphogenetic protein 14, GDF5, Growth/differentiation factor 5.

Introduction

GDF-5 is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。 该家族的成员是胚胎和成人组织中细胞生长和分化的调节剂。 该基因的突变与Hunter-Thompson型肢端发育不良有关； 短指，C型； 和软骨发育不良，Grebe型。 这些关联证实基因产物在骨骼发育中发挥作用。

Description

GDF5 Mouse Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 120 amino acids and having a molecular mass of 27.2kDa.
The GDF-5 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 GDF5 Mouse Recombinant 是一种非糖基化的二硫键连接的同源二聚体，包含 2 条 120 个氨基酸的链，分子量为 27.2kDa。
GDF-5 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

GDF-5 protein was lyophilized from a 0.2µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.

Solubility

It is recommended to reconstitute the lyophilized GDF5 in sterile 4mM HCl not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议在不低于 100µg/ml 的无菌 4mM HCl 中复溶冻干的 GDF5，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized GDF5 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 GDF5 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，GDF-5 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 96.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR.

Biological Activity

The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 1.0µg/ml, corresponding to a specific activity of > 1000IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

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ProSpec-GDF5 Mouse, His/CYT-852,Growth differentiation factor 5 Mouse Recombinant, His Tag

ProSpec-GDF5 Mouse, His/CYT-852,Growth differentiation factor 5 Mouse Recombinant, His Tag,GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。

GDF5 Mouse, His

Growth differentiation factor 5 Mouse Recombinant, His Tag
CYT-852
5µg
20µg
1mg

Catalogue number

CYT-852

Synonyms

Bmp-14, Bp, GDF-5, Bone morphogenetic protein 14, GDF5.

Introduction

GDF-5 is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
GDF-5 是骨形态发生蛋白家族和 TGF-β 超家族的成员。 这组蛋白质的特征在于多元蛋白水解加工位点，该位点被切割以产生含有七个保守半胱氨酸残基的成熟蛋白。 该家族的成员是胚胎和成人组织中细胞生长和分化的调节剂。 该基因的突变与Hunter-Thompson型肢端发育不良有关； 短指，C型； 和软骨发育不良，Grebe型。 这些关联证实基因产物在骨骼发育中发挥作用。

Description

GDF5 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 143 amino acids and having a molecular mass of 16kDa.
GDF5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 GDF5 Mouse Recombinant 是一条单一的、非糖基化的多肽链，包含 143 个氨基酸，分子量为 16kDa。
GDF5 在 N 端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

GDF5 protein solution containing 20mM Tris-HCl buffer and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSAPLANRQ GKRPSKNLKA RCSRKALHVN FKDMGWDDWI IAPLEYEAFH CEGLCEFPLR SHLEPTNHAV IQTLMNSMDP ESTPPTCCVP TRLSPISILF IDSANNVVYK QYEDMVVESC GCR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

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ProSpec-GDF7 Human/CYT-870

ProSpec GDF7 Human,ProSpec CYT-870,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,生长分化因子 7 属于 TGF-b 超家族蛋白的 BMP 家族。 GDF7 通过由 1 型和 II 型丝氨酸/苏氨酸激酶受体组成的异二聚体受体复合物引发其生物活性。 GDF7 信号传导导致 Smad 蛋白的磷酸化和活化。 GDF-7 也参与肌腱和韧带的形成和修复。 此外，GDF7 调节骨形成、间充质干细胞分化、神经元分化和轴突引导。

GDF7 Human

Growth and Differentiation factor 7 Human Recombinant
CYT-870
ProSpec-GDF7 Human/CYT-870 2µg
ProSpec-GDF7 Human/CYT-870 10µg
ProSpec-GDF7 Human/CYT-870 1mg

Catalogue number

CYT-870

Synonyms

Growth Differentiation Factor 7, GDF-7, Growth/Differentiation Factor 7, BMP12, GDF7.

Introduction

Growth Differentiation Factor-7 belongs to the BMP family of TGF-b superfamily proteins. GDF7 elicits its bioactivity via a heterodimeric receptor complex comprised of a type 1 and a type II serine/threonine kinase receptor. GDF7 signaling results in the phosphorylation and activation of Smad proteins. GDF-7 is also involved in tendon and ligament formation and repair. In addition, GDF7 regulates bone formation, mesenchymal stem cell differentiation, neuronal differentiation, and axon guidance.
生长分化因子 7 属于 TGF-b 超家族蛋白的 BMP 家族。 GDF7 通过由 1 型和 II 型丝氨酸/苏氨酸激酶受体组成的异二聚体受体复合物引发其生物活性。 GDF7 信号传导导致 Smad 蛋白的磷酸化和活化。 GDF-7 也参与肌腱和韧带的形成和修复。 此外，GDF7 调节骨形成、间充质干细胞分化、神经元分化和轴突引导。

Description

GDF7 Human Recombinant produced in E.Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 28kDa.
The GDF-7 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 GDF7 Human Recombinant 是一种二硫键连接的同型二聚体、非糖基化多肽链，包含 129 个氨基酸，分子量为 28kDa。
GDF-7 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered solution in HCl.

Solubility

It is recommended to reconstitute the lyophilized GDF-7 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议在不低于 100µg/ml 的无菌 18M-cm H2O 中复溶冻干的 GDF-7，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized GDF7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-7 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 GDF7 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，GDF-7 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR.

Biological Activity

The ED50, as determined by inducing alkaline phosphatase production by mouse ATDC5 cells, is less than 1.25µg/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • GDF7 Mouse

ProSpec-GDF7 Mouse/CYT-946,Growth and Differentiation factor 7 Mouse Recombinant

ProSpec GDF7 Mouse,ProSpec CYT-946,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,生长分化因子 7 属于 TGF-b 超家族蛋白的 BMP 家族。 GDF7 通过由 1 型和 II 型丝氨酸/苏氨酸激酶受体组成的异二聚体受体复合物引发其生物活性。

GDF7 Mouse

Growth and Differentiation factor 7 Mouse Recombinant
CYT-946
ProSpec-GDF7 Mouse/CYT-946,Growth and Differentiation factor 7 Mouse Recombinant 2µg
ProSpec-GDF7 Mouse/CYT-946,Growth and Differentiation factor 7 Mouse Recombinant 10µg
ProSpec-GDF7 Mouse/CYT-946,Growth and Differentiation factor 7 Mouse Recombinant 1mg

Catalogue number

CYT-946

Synonyms

Growth/differentiation factor 7, GDF-7, Gdf7.

Introduction

Growth Differentiation Factor-7 belongs to the BMP family of TGF-b superfamily proteins. GDF7 elicits its bioactivity via a heterodimeric receptor complex comprised of a type 1 and a type II serine/threonine kinase receptor. GDF7 signaling results in the phosphorylation and activation of Smad proteins. GDF-7 is also involved in tendon and ligament formation and repair. In addition, GDF7 regulates bone formation, mesenchymal stem cell differentiation, neuronal differentiation, and axon guidance.
生长分化因子 7 属于 TGF-b 超家族蛋白的 BMP 家族。 GDF7 通过由 1 型和 II 型丝氨酸/苏氨酸激酶受体组成的异二聚体受体复合物引发其生物活性。 GDF7 信号传导导致 Smad 蛋白的磷酸化和活化。 GDF-7 也参与肌腱和韧带的形成和修复。 此外，GDF7 调节骨形成、间充质干细胞分化、神经元分化和轴突引导。

Description

GDF7 Mouse Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 146 amino acids and having a molecular mass of 29.8kDa.
The GDF-7 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 GDF7 Mouse Recombinant 是一种非糖基化的二硫键连接的同源二聚体，包含 2 条 146 个氨基酸的链，分子量为 29.8kDa。
GDF-7 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

GDF7 protein was lyophilized from a 0.2µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.

Solubility

It is recommended to reconstitute the lyophilized GDF-7 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized GDF7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-7 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 GDF7 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，GDF-7 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

TALAGTRGAQ GSGGGGGGGG GGGGGGGGGG GGAGRGHGRR GRSRCSRKSL HVDFKELGWD DWIIAPLDYE AYHCEGVCDF PLRSHLEPTN HAIIQTLLNS MAPDAAPASC CVPARLSPIS ILYIDAANNV VYKQYEDMVV EACGCR.

Biological Activity

The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 0.5µg/ml, corresponding to a specific activity of > 2000 IU/mg.

通过诱导鼠 ATDC5 细胞产生碱性磷酸酶测定的 ED50 小于 0.5μg/ml，对应于 > 2000 IU/mg 的比活性。

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • GDF7 Human

ProSpec-TSG Human/CYT-873,Twisted Gastrulation Protein Human Recombinant

ProSpec TSG Human,ProSpec CYT-873,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,扭曲的原肠胚形成蛋白是一种分泌的富含半胱氨酸的蛋白质，它通过调节 BMP 信号传导在果蝇和非洲爪蟾的背侧/腹侧模式中发挥作用。 TSG 通过控制 BMP 拮抗剂 Chordin/Sog 的抑制作用和金属蛋白酶 xolloid/tolloid 的切割特性，充当 BMP 信号传导的激动剂。 TSG N 末端结构域直接结合 BMP 蛋白并显示 BMP 拮抗剂活性。

TSG Human

Twisted Gastrulation Protein Human Recombinant
CYT-873
ProSpec-TSG Human/CYT-873 10µg
ProSpec-TSG Human/CYT-873 50µg
ProSpec-TSG Human/CYT-873 1mg

Catalogue number

CYT-873

Synonyms

Twisted Gastrulation BMP Signaling Modulator 1, TSG, Twisted Gastrulation Homolog 1 , Twisted Gastrulation Protein Homolog 1, Twisted Gastrulation Homolog 1, TWSG1.

Introduction

Twisted gastrulation Protein is a secreted, cysteine-rich protein which has a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG functions as an agonist for BMP signaling by controlling the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. TSG N-terminal domain binds BMP protein directly and displays BMP antagonist activity.
扭曲的原肠胚形成蛋白是一种分泌的富含半胱氨酸的蛋白质，它通过调节 BMP 信号传导在果蝇和非洲爪蟾的背侧/腹侧模式中发挥作用。 TSG 通过控制 BMP 拮抗剂 Chordin/Sog 的抑制作用和金属蛋白酶 xolloid/tolloid 的切割特性，充当 BMP 信号传导的激动剂。 TSG N 末端结构域直接结合 BMP 蛋白并显示 BMP 拮抗剂活性。

Description

TWSG1 Human Recombinant produced in CHO is a single, glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass ranging from 35-43kDa on -PAGE due to glycosylation.
The TWSG1 is purified by proprietary chromatographic techniques.
在 CHO 中产生的 TWSG1 Human Recombinant 是单条糖基化多肽链，含有 198 个氨基酸，由于糖基化，-PAGE 上的分子量范围为 35-43kDa。
TWSG1 通过专有的色谱技术进行纯化。

Source

CHO.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered solution in PBS.

Solubility

It is recommended to reconstitute the lyophilized TSG in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议在不低于 100µg/ml 的无菌 18M-cm H2O 中复溶冻干的 TSG，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized TSG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TSG should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 TSG 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，TSG 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

CNKALCASDV SKCLIQELCQ CRPGEGNCSC CKECMLCLGA LWDECCDCVG MCNPRNYSDT PPTSKSTVEE LHEPIPSLFR ALTEGDTQLN WNIVSFPVAE ELSHHENLVS FLETVNQPHH QNVSVPSNNV HAPYSSDKEH MCTVVYFDDC MSIHQCKISC ESMGASKYRW FHNACCECIG PECIDYGSKT VKCMN CMF.

Biological Activity

The ED50, as measured by its ability to inhibit alkaline phosphatase production induced by rHuBMP-6 in mouse ATDC5 cells, is less than 16µg/ml.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-BST1 Human/CYT-1071,Bone Marrow Stromal Cell Antigen 1 Human Recombinant

ProSpec BST1 Human,ProSpec CYT-1071,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,BST1 , is a GPI anchored membrane protein which is part of the CD38 family. BST1 was initially recognized as a bone marrow stromal cell molecule. BST1 is an ectoenzyme sharing more than a few features with ADP-ribosyl cyclase CD38. BST1 together with CD38, exhibit both DP-ribosyl cyclase and cyclinc ADP ribose hydrolase activities.

BST1 Human

Bone Marrow Stromal Cell Antigen 1 Human Recombinant
CYT-1071
ProSpec-BST1 Human/CYT-1071 2µg
ProSpec-BST1 Human/CYT-1071 10µg
ProSpec-BST1 Human/CYT-1071 1mg

Catalogue number

CYT-1071

Synonyms

Bone Marrow Stromal Cell Antigen 1, ADP-Ribosyl Cyclase 2, Bone Marrow Stromal Antigen 1, Cyclic ADP-Ribose Hydrolase 2, NAD Nucleosidase, CADPr Hydrolase 2, ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 2, CD157 Antigen, EC 3.2.2.6, CD157, BST-1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Bone marrow stromal antigen 1, Cyclic ADP-ribose hydrolase 2, cADPr hydrolase 2.

骨髓基质细胞抗原 1、ADP-核糖基环化酶 2、骨髓基质抗原 1、环状 ADP-核糖水解酶 2、NAD 核苷酶、CADPr 水解酶 2、ADP-核糖基环化酶/环状 ADP-核糖水解酶 2、CD157 抗原、EC 3.2 .2.6、CD157、BST-1、ADP-核糖基环化酶/环状 ADP-核糖水解酶 2、ADP-核糖基环化酶 2、骨髓基质抗原 1、环状 ADP-核糖水解酶 2、cADPr 水解酶 2。

Introduction

BST1 , is a GPI anchored membrane protein which is part of the CD38 family. BST1 was initially recognized as a bone marrow stromal cell molecule. BST1 is an ectoenzyme sharing more than a few features with ADP-ribosyl cyclase CD38. BST1 together with CD38, exhibit both DP-ribosyl cyclase and cyclinc ADP ribose hydrolase activities. BST1 participates in rheumatoid arthritis due to its enhanced expression in RA-derived bone marrow stromal cell lines. Moreover, BST1 is expressed by cells of the myeloid lineage and could perform as a receptor with a signal transduction capability.

BST1 是一种 GPI 锚定膜蛋白，它是 CD38 家族的一部分。 BST1 最初被认为是一种骨髓基质细胞分子。 BST1 是一种与 ADP-核糖基环化酶 CD38 共享多个特征的外酶。 BST1 与 CD38 一起表现出 DP-核糖基环化酶和 cyclinc ADP 核糖水解酶活性。 BST1 参与类风湿性关节炎，因为它在 RA 衍生的骨髓基质细胞系中表达增强。 此外，BST1 由髓系细胞表达，可以作为具有信号转导能力的受体发挥作用。

Description

BST1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 267 amino acids and having a molecular mass of 30.5kDa. .
BST1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 BST1 是单条糖基化多肽链，包含 267 个氨基酸，分子量为 30.5kDa。 .
BST1 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

BST1 protein solution contains 10% glycerol & Phosphate Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

RWRGEGTSAH LRDIFLGRCA EYRALLSPEQ RNKNCTAIWE AFKVALDKDP CSVLPSDYDL FINLSRHSIP RDKSLFWENS HLLVNSFADN TRRFMPLSDV LYGRVADFLS WCRQKNDSGL DYQSCPTSED CENNPVDSFW KRASIQYSKD SSGVIHVMLN GSEPTGAYPI KGFFADYEIP NLQKEKITRI EIWVMHEIGG PNVESCGEGS MKVLEKRLKD MGFQYSCIND YRPVKLLQCV DHSTHPDCAL KSAAAATQRK AHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Prospec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-BST2 Human/CYT-059

ProSpec BST2 Human,ProSpec CYT-059,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,BST2 参与 B 细胞的生长和发育。 人类细胞蛋白 BST2 通过在受感染细胞出芽后维持病毒颗粒的扩散来抑制逆转录病毒感染。 BST2 最初被发现是在没有 Vpu 的情况下作为 HIV-1 感染的抑制剂，但也已知它可以抑制其他病毒的释放，例如 Lassa 和 Marburg 病毒粒子。 此外，BST2 在类风湿性关节炎中参与 B 细胞活化。

BST2 Human

Bone Marrow Stromal Cell Antigen 2 Human Recombinant
CYT-059
ProSpec-BST2 Human/CYT-059 2µg
ProSpec-BST2 Human/CYT-059 10µg
ProSpec-BST2 Human/CYT-059 1mg

Catalogue number

CYT-059

Synonyms

Bone marrow stromal cell antigen 2, CD317 antigen, BST-2, HM1.24 antigen, Tetherin,
NPC-A-7.

Introduction

BST2 takes part in the growth and development of B-cells. The human cellular protein BST2 inhibits retrovirus infection by maintaining the diffusion of virus particles after budding from infected cells. BST2 was originally discovered as an inhibitor to HIV-1 infection in the absence of Vpu, but it is also known to inhibit the release of other viruses such as the Lassa and Marburg virions. In addition, BST2 has a part in B-cell activation in rheumatoid arthritis.
BST2 参与 B 细胞的生长和发育。 人类细胞蛋白 BST2 通过在受感染细胞出芽后维持病毒颗粒的扩散来抑制逆转录病毒感染。 BST2 最初被发现是在没有 Vpu 的情况下作为 HIV-1 感染的抑制剂，但也已知它可以抑制其他病毒的释放，例如 Lassa 和 Marburg 病毒粒子。 此外，BST2 在类风湿性关节炎中参与 B 细胞活化。

Description

BST2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids and having a molecular mass of 14.8 kDa.
The BST2 is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 BST2 Human Recombinant 是单条非糖基化多肽链，包含 133 个氨基酸，分子量为 14.8 kDa。
BST2 在 N 末端与 21 个氨基酸的 His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

BST2 is supplied as a sterile filtered clear solution.

Formulation

BST2 protein 0.5mg/ml is supplied in 20mM Tris-HCl, pH-8, 0.1M NaCl, 1mM DTT and 20% Glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 80.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MSEACRDGLR AVMECRNVTH LLQQELTEAQ KGFQDVEAQA ATCNHTVMAL MASLDAEKAQ GQKKVEELEG EITTLNHKLQ DASAEVERLR RENQVLSVRI ADKKYYPSSQ DSS

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Prospec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-BNP/CYT-327,B-type Natriuretic Peptide Human Recombinant

ProSpec BNP,ProSpec CYT-327,B-type Natriuretic Peptide Human Recombinant,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,冻干的 B 型利钠肽虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，NPPB 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

BNP

B-type Natriuretic Peptide Human Recombinant
CYT-327
ProSpec-BNP/CYT-327 2µg
ProSpec-BNP/CYT-327 10µg
ProSpec-BNP/CYT-327 1mg

Catalogue number

CYT-327

Synonyms

NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide.

Introduction

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body’s salt and water balance. Improves heart function.
利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利尿钠、利尿、血管舒张以及抑制肾素和醛固酮分泌。 它被认为在心血管稳态中起关键作用。 帮助恢复身体的盐分和水分平衡。 改善心脏功能。

Description

B-type Natriuretic Peptide Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 32 amino acids and having a molecular mass of 3,500 Dalton. NPPB is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 B 型利钠肽重组人是单条非糖基化多肽链，含有 32 个氨基酸，分子量为 3,500 道尔顿。 NPPB 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Natriuretic Peptide Precursor B was lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized B-type Natriuretic Peptide in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized B-type Natriuretic Peptide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NPPB should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 B 型利钠肽虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，NPPB 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

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  • BNP Human
  • NT-proBNP Human
  • proBNP Human

ProSpec-BNP (27-102) Human/CYT-1029

ProSpec BNP (27-102) Human,ProSpec CYT-1029,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,BNP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids including a 7 a.a N-terminal His tag. The total molecular mass is 9.4kDa . 

BNP Human

B-type Natriuretic Protein Human Recombinant
CYT-1029
ProSpec-BNP (27-102) Human/CYT-1029 2µg
ProSpec-BNP (27-102) Human/CYT-1029 10µg
ProSpec-BNP (27-102) Human/CYT-1029 1mg

Catalogue number

CYT-1029

Synonyms

NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide.

Introduction

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body’s salt and water balance. Improves heart function.

利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利尿钠、利尿、血管舒张以及抑制肾素和醛固酮分泌。 它被认为在心血管稳态中起关键作用。 帮助恢复身体的盐分和水分平衡。 改善心脏功能。

Description

BNP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids including a 7 a.a N-terminal His tag. The total molecular mass is 9.4kDa .

在大肠杆菌中产生的 BNP Human Recombinant 是一条单一的、非糖基化的多肽链，包含 83 个氨基酸，包括一个 7 个氨基酸的 N 端 His 标签。 总分子量为9.4kDa。

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized powder.

Formulation

BNP filtered and lyophilized from 0.5mg/ml in 20 mM Tris buffer and 50 mM NaCl, pH 7.5.

Solubility

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. BNP is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 BNP 不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
将冻干蛋白储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MKHHHHHHPL GSPGSASDLE TSGLQEQRNH LQGKLSELQV EQTSLEPLQE SPRPTGVWKS REVATEGIRG HRKMVLYTLR APR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • BNP
  • BNP Human
  • BNP Human, His
  • NT-proBNP Human
  • proBNP Human

ProSpec-BNP Human/CYT-369,B-type Natriuretic Peptide Human

ProSpec BNP Human,ProSpec CYT-369,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利尿钠、利尿、血管舒张以及抑制肾素和醛固酮分泌。 它被认为在心血管稳态中起关键作用。 帮助恢复身体的盐分和水分平衡。 改善心脏功能。

BNP Human

B-type Natriuretic Peptide Human
CYT-369
10mg
25mg
100mg

Catalogue number

CYT-369

Synonyms

NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide.

Introduction

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body’s salt and water balance. Improves heart function.
利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利尿钠、利尿、血管舒张以及抑制肾素和醛固酮分泌。 它被认为在心血管稳态中起关键作用。 帮助恢复身体的盐分和水分平衡。 改善心脏功能。

Description

B-type Natriuretic Peptide Human is a polypeptide chain containing 32 amino acids and having a molecular mass of 3464 Dalton. The molecular formula is:C143H244N50O42S4.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized without additives.

Solubility

It is recommended to reconstitute the lyophilized B-type Natriuretic Peptide in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议将冻干的 B 型利钠肽在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized B-type Natriuretic Peptide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution B-type Natriuretic Peptide should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 B 型利钠肽虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，B 型利钠肽应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by RP-HPLC.

Amino acid sequence

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • BNP
  • BNP Human, His
  • BNP Human
  • NT-proBNP Human
  • proBNP Human

ProSpec-BNP Human, His/CYT-605

ProSpec BNP Human His,ProSpec CYT-605,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide.

BNP Human, His

B-type Natriuretic Peptide Human Recombinant, His Tag
CYT-605
ProSpec-BNP Human, His/CYT-605 2µg
ProSpec-BNP Human, His/CYT-605 10µg
ProSpec-BNP Human, His/CYT-605 1mg

Catalogue number

CYT-605

Synonyms

NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide.

Introduction

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body’s salt and water balance. Improves heart function.
利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利尿钠、利尿、血管舒张以及抑制肾素和醛固酮分泌。 它被认为在心血管稳态中起关键作用。 帮助恢复身体的盐分和水分平衡。 改善心脏功能。

Description

BNP Recombinant Human fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 14 kDa.
BNP is purified by proprietary chromatographic techniques.
BNP Recombinant Human 在 N 末端融合了 20 个氨基酸的 His 标签，在大肠杆菌中产生，是一条单一的、非糖基化的多肽链，包含 129 个氨基酸，分子量为 14 kDa。
BNP 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

BNP 1mg/ml is formulated with 1X PBS pH-7.4, 2mM DTT, 0.1mM PMSF, 1mM EDTA and 40% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 90.0% as determined by analysis by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MHPLGSPGSA SDLETSGLQE QRNHLQGKLSELQVEQTSLE PLQESPRPTG VWKSREVATE GIRGHRKMVL YTLRAPRSPK MVQGSGCFGR KMDRISSSSG LGCKVLRRH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • BNP
  • BNP Human
  • BNP Human
  • NT-proBNP Human
  • proBNP Human

ProSpec-NPPA Human/CYT-1028,Natriuretic Peptide A Human Recombinant

ProSpec NPPA Human,ProSpec CYT-1028,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Natriuretic peptides A, CDD-ANF, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, N-terminal proatrial natriuretic peptide, ANP, PND. 

NPPA Human

Natriuretic Peptide A Human Recombinant
CYT-1028
ProSpec-NPPA Human/CYT-1028 2µg
ProSpec-NPPA Human/CYT-1028 10µg
ProSpec-NPPA Human/CYT-1028 1mg

Catalogue number

CYT-1028

Synonyms

Natriuretic peptides A, CDD-ANF, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, N-terminal proatrial natriuretic peptide, ANP, PND.

Introduction

Natriuretic Peptide A is a part of the natriuretic peptide family and is involved  in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. NPPA is synthesized as a great precursor which releases a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. In female pregnancy, NPPA is promoting trophoblast invasion and spiral artery remodeling in uterus.

利钠肽 A 是利钠肽家族的一部分，通过调节利钠、利尿和血管舒张参与心血管稳态。 NPPA 被合成为一种伟大的前体，它从 N 端释放一种与血管活性肽、心脏扩张肽相似的肽，并从 C 端释放另一种具有利钠利尿活性的肽。 在女性妊娠期，NPPA 促进子宫内滋养层侵袭和螺旋动脉重塑。

Description

NPPA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 106 amino acids including an 8 a.a N-terminal His tag. The total molecular mass is 11.7kDa .

在大肠杆菌中产生的 NPPA Human Recombinant 是一种单一的、非糖基化的多肽链，包含 106 个氨基酸，包括一个 8 个氨基酸的 N 端 His 标签。 总分子量为11.7kDa。

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized powder.

Formulation

NPPA filtered and lyophilized from 0.5mg/ml in 20 mM Tris buffer, 50 mM NaCl and 5% w/v trehalosa, pH 7.5.

Solubility

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. NPPA is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 NPPA 不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
将冻干蛋白储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重组蛋白可在 4°C 下保存一段时间； 在 4°C 下两周后它没有显示任何变化。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MKHHHHHHNP MYNAVSNADL MDFKNLLDHL EEKMPLEDEV VPPQVLSEPN EEAGAALSPL PEVPPWTGEV SPAQRDGGAL GRGPWDSSDR SALLKSKLRA LLTAPR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-NPPC Human/CYT-760,Natriuretic Peptide C Human Recombinant

ProSpec NPPC Human,ProSpec CYT-760,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,NPPC 被蛋白水解处理以产生利钠肽家族的分泌激素。 NPPC 具有血管活性和利钠作用，并控制软骨生长板软骨细胞的进化和分化。

NPPC Human

Natriuretic Peptide C Human Recombinant
CYT-760
ProSpec-NPPC Human/CYT-760 5µg
ProSpec-NPPC Human/CYT-760 20µg
ProSpec-NPPC Human/CYT-760 1mg

Catalogue number

CYT-760

Synonyms

Natriuretic Peptide Precursor C, C-Type Natriuretic Peptide, CNP2, CNP.

Introduction

NPPC is proteolytically managed to create a secreted hormone of the natriuretic peptide family. NPPC is vasoactive and natriuretic and controls the evolution and differentiation of cartilaginous growth plate chondrocytes.
NPPC 被蛋白水解处理以产生利钠肽家族的分泌激素。 NPPC 具有血管活性和利钠作用，并控制软骨生长板软骨细胞的进化和分化。

Description

NPPC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 126 amino acids and having a molecular mass of 13.2kDa.
NPPC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 NPPC Human Recombinant 是单条非糖基化多肽链，包含 126 个氨基酸，分子量为 13.2kDa。
NPPC 在 N 末端与 23 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The NPPC solution contains 20mM Tris-HCl buffer , 0.15M NaCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSKPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS MSGLGC

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpecs 产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-NT-proBNP Human/CYT-1118

ProSpec NT-proBNP Human,ProSpec CYT-1118,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利钠、血管舒张、利尿以及抑制肾素和醛固酮的分泌。 BNP 在心血管稳态中起关键作用。 BNP 还有助于恢复身体的盐和水平衡并改善心脏功能。

NT-proBNP Human

NT-Pro-B-type Natriuretic Protein Human Recombinant
CYT-1118
ProSpec-NT-proBNP Human/CYT-1118 10µg
ProSpec-NT-proBNP Human/CYT-1118 50µg
ProSpec-NT-proBNP Human/CYT-1118 1mg

Catalogue number

CYT-1118

Synonyms

NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide.

Introduction

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis,vasorelaxation,diuresis and inhibition of renin and aldosterone secretion. BNP plays a key role in cardiovascular homeostasis. BNP also helps restore the body’s salt and water balance andimproves heart function.

利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利钠、血管舒张、利尿以及抑制肾素和醛固酮的分泌。 BNP 在心血管稳态中起关键作用。 BNP 还有助于恢复身体的盐和水平衡并改善心脏功能。

Description

NT-Pro-B-type Natriuretic Protein Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 76 amino acid and having a molecular mass of approximately 8.5kDa.

NT-proBNP is purified by proprietary chromatographic techniques.

NT-Pro-B-type Natriuretic Protein Human Recombinant 在大肠杆菌中产生，是一种非糖基化多肽链，含有 76 个氨基酸，分子量约为 8.5kDa。

NT-proBNP 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM Tris-HCl, pH 8.0 and 150mM NaCl.

从 20mM Tris-HCl、pH 8.0 和 150mM NaCl 中的 0.2μm 过滤浓缩溶液冻干。

Solubility

It is recommended to reconstitute the lyophilized NT-Pro-B-type Natriuretic Protein in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的 NT-Pro-B 型利钠蛋白在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized NT-proBNP although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NT-Pro-B-type Natriuretic Protein should be stored at 4°C between 2-7 days and for future use below -18°C.

冻干的 NT-proBNP 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，NT-Pro-B 型利尿钠蛋白应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

HPLGSPGSAS DLETSGLQEQ RNHLQGKLSE LQVEQTSLEP LQESPRPTGV WKSREVATEG IRGHRKMVLY TLRAPR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • BNP Human
  • BNP
  • BNP Human
  • BNP Human, His
  • proBNP Human

ProSpec-proBNP Human/CYT-1205

ProSpec proBNP Human,ProSpec CYT-1205,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,在大肠杆菌中产生的重组人 Pro B 型利尿钠蛋白是单一的、非糖基化的多肽链，与 His 标签融合，分子量约为 13kDa。proBNP 通过专有的色谱技术进行纯化。

proBNP Human

Pro B-type Natriuretic Protein Human Recombinant
CYT-1205
ProSpec-proBNP Human/CYT-1205 25µg
ProSpec-proBNP Human/CYT-1205 50µg
ProSpec-proBNP Human/CYT-1205 100µg

Catalogue number

CYT-1205

Synonyms

NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide

Introduction

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body’s salt and water balance. Improves heart function.

利钠肽前体 B 作为一种心脏激素，具有多种生物作用，包括利尿钠、利尿、血管舒张以及抑制肾素和醛固酮分泌。 它被认为在心血管稳态中起关键作用。 帮助恢复身体的盐分和水分平衡。 改善心脏功能。

Description

Recombinant Human Pro B-type Natriuretic Protein produced in E.Coli is a single, non-glycosylated, polypeptide chain , fused to His-tag and having a molecular weight of ~13kDa.
The proBNP is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的重组人 Pro B 型利尿钠蛋白是单一的、非糖基化的多肽链，与 His 标签融合，分子量约为 13kDa。
proBNP 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless liquid formulation.

Formulation

Human proBNP solution contains 500 mM NaCl, 20mM Tris-HCl, 4mM CaCl2, 4mM MgCl2and 60 mM B-mercaptoethanol, pH 7.5.

Stability

proBNP although stable at 10°C for 7 days, should be stored below -18°C.
Please prevent freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • BNP
  • BNP Human, His
  • BNP Human
  • BNP Human
  • NT-proBNP Human

ProSpec-CTF1 Human/CYT-944

ProSpec CTF1 Human,ProSpec CYT-944,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0×106 IU/mg.

CTF1 Human

Cardiotrophin-1 Human Recombinant
CYT-944
ProSpec-CTF1 Human/CYT-944 2µg
ProSpec-CTF1 Human/CYT-944 10µg
ProSpec-CTF1 Human/CYT-944 1mg

Catalogue number

CYT-944

Synonyms

CTF1, CT1, CT-1, Cardiophin 1, Cardiotrophin-1.

Introduction

Cardiotrophin 1 is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes.
CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. Cardiotrophin 1 can induce expression of the protective heat shock proteins in cardiac cells.
Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide and angiotensinogen mRNA.
Cardiophin 1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction.
心肌营养素 1 是白细胞介素 6 超家族的 201 个氨基酸成员。它是通过其在心肌细胞中诱导肥大反应的能力来确定的。 CT-1 mRNA 水平在心肌细胞和心脏非心肌细胞中均存在。 CT 1 在正常成人肺中也大量检测到，并在胎儿和成人气道平滑肌细胞中表达。 CT 1 激活 gp130 依赖性信号传导并刺激 Janus 激酶/信号转导和转录途径激活因子，以转导心肌细胞中的肥大和细胞保护信号。
CT 1 还具有神经营养功能。在胚胎第 14 天和出生后第一周之间，CTF1 缺乏导致小鼠脊髓和脑干核中运动神经元细胞死亡增加。此外，CT-1 是一种肝细胞存活因子，可有效减少急性肝损伤动物模型中的肝细胞损伤。心肌营养因子 1 的表达在缺氧刺激后增强，当在模拟缺血之前或在模拟缺血后的复氧时添加时，它可以保护心肌细胞。 Cardiotrophin 1 可以诱导心脏细胞中保护性热休克蛋白的表达。
Cardiotrophin-1 增加 ANP、脑利钠肽和血管紧张素原 mRNA 的心室表达。
Cardiophin 1 水平在心力衰竭患者、扩张型心肌病患者、中/重度二尖瓣关闭不全、稳定和不稳定型心绞痛患者以及急性心肌梗死后显着升高。

Description

Cardiotrophin-1 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 201 amino acids and having a molecular mass of 21.2kDa.
The CTF1 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 Cardiotrophin-1 Human Recombinant 是一条单一的、非糖基化的多肽链，含有 201 个氨基酸，分子量为 21.2kDa。
CTF1 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

CTF-1 protein was lyophilized from a 0.2µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.

Solubility

It is recommended to reconstitute the lyophilized CTF1 in sterile 4mM HCl not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议在不低于 100µg/ml 的无菌 4mM HCl 中复溶冻干的 CTF1，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized CTF1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CTF-1 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 CTF1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CTF-1 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS A.

Biological Activity

The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0×106 IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • CTF1 Human, His
  • CTF1 Rat
  • CTF1 Mouse

ProSpec-CTF1 Human, His/CYT-436

ProSpec CTF1 Human, His,ProSpec CYT-436,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Purity of CTF1 Human Recombinant is greater than 90% as determined by -PAGE.

CTF1 Human, His

Cardiotrophin-1 Human Recombinant, His Tag
CYT-436
ProSpec-CTF1 Human, His/CYT-436 2µg
ProSpec-CTF1 Human, His/CYT-436 10µg
ProSpec-CTF1 Human, His/CYT-436 1mg

Catalogue number

CYT-436

Synonyms

CTF1, CT1, CT-1, Cardiophin 1.

Introduction

Cardiotrophin 1 is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes.
CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. Cardiotrophin 1 can induce expression of the protective heat shock proteins in cardiac cells.
Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide and angiotensinogen mRNA.
Cardiophin 1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction.
心肌营养素 1 是白细胞介素 6 超家族的 201 个氨基酸成员。它是通过其在心肌细胞中诱导肥大反应的能力来确定的。 CT-1 mRNA 水平在心肌细胞和心脏非心肌细胞中均存在。 CT 1 在正常成人肺中也大量检测到，并在胎儿和成人气道平滑肌细胞中表达。 CT 1 激活 gp130 依赖性信号传导并刺激 Janus 激酶/信号转导和转录途径激活因子，以转导心肌细胞中的肥大和细胞保护信号。
CT 1 还具有神经营养功能。在胚胎第 14 天和出生后第一周之间，CTF1 缺乏导致小鼠脊髓和脑干核中运动神经元细胞死亡增加。此外，CT-1 是一种肝细胞存活因子，可有效减少急性肝损伤动物模型中的肝细胞损伤。心肌营养因子 1 的表达在缺氧刺激后增强，当在模拟缺血之前或在模拟缺血后的复氧时添加时，它可以保护心肌细胞。 Cardiotrophin 1 可以诱导心脏细胞中保护性热休克蛋白的表达。
Cardiotrophin-1 增加 ANP、脑利钠肽和血管紧张素原 mRNA 的心室表达。
Cardiophin 1 水平在心力衰竭患者、扩张型心肌病患者、中/重度二尖瓣关闭不全、稳定和不稳定型心绞痛患者以及急性心肌梗死后显着升高。

Description

The Cardiotrophin His-Tagged Fusion Protein Human, produced in E. coli, is 22.5 kDa protein containing 200 amino acid residues of the human Cardiotrophin and 12 additional amino acid residues – His Tag .
在大肠杆菌中产生的 Cardiotrophin His-Tagged Fusion Protein Human 是一种 22.5 kDa 的蛋白质，含有人 Cardiotrophin 的 200 个氨基酸残基和 12 个额外的氨基酸残基 – His 标签。

Source

Escherichia Coli.

Formulation

CTF1 was filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.

Solubility

It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited. Protein is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
建议加入 0.1M 醋酸盐缓冲液 pH-4 制备约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 为了转化为更高的 pH 值，我们建议使用相关缓冲液将其充分稀释至 10?g/ml 的浓度。 在较高浓度下，该抗原的溶解度是有限的。 蛋白质不是无菌的！ 在细胞培养中使用之前，请用适当的无菌过滤器过滤产品。

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Amino acid sequence

MRGSHHHHHH GSSRREGSLE DPQTDSSVSL LPHLEAKIRQ THSLAHLLTK YAEQLLQEYV QLQGDPFGLPSFSPPRLPVA GLSAPAPSHA GLPVHERLRL DAAALAALPP LLDAVCRRQA ELNPRAPRLL RRLEDAARQA RALGAAVEAL LAALGAANRG PRAEPPAATA SAASATGVFP AKVLGLRVCG LYREWLSRTE GDLGQLLPGG SA.

Purity

Purity of CTF1 Human Recombinant is greater than 90% as determined by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CTF1 Mouse
  • CTF1 Human
  • CTF1 Rat

ProSpec-CTF1 Mouse/CYT-151

ProSpec CTF1 Mouse,ProSpec CYT-151,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,由 TF-1 细胞的剂量依赖性增殖确定的 ED50 < 1.0ng/ml，对应于 > 1,000,000units/mg 的比活性。

CTF1 Mouse

Cardiotrophin-1 Mouse Recombinant
CYT-151
ProSpec-CTF1 Mouse/CYT-151 2µg
ProSpec-CTF1 Mouse/CYT-151 10µg
ProSpec-CTF1 Mouse/CYT-151 1mg

Catalogue number

CYT-151

Synonyms

CTF1, CT1, CT-1, Cardiophin 1.

Introduction

Cardiotrophin 1 is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes.
CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. Cardiotrophin 1 can induce expression of the protective heat shock proteins in cardiac cells.
Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide and angiotensinogen mRNA.
Cardiophin 1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction.
心肌营养素 1 是白细胞介素 6 超家族的 201 个氨基酸成员。它是通过其在心肌细胞中诱导肥大反应的能力来确定的。 CT-1 mRNA 水平在心肌细胞和心脏非心肌细胞中均存在。 CT 1 在正常成人肺中也大量检测到，并在胎儿和成人气道平滑肌细胞中表达。 CT 1 激活 gp130 依赖性信号传导并刺激 Janus 激酶/信号转导和转录途径激活因子，以转导心肌细胞中的肥大和细胞保护信号。
CT 1 还具有神经营养功能。在胚胎第 14 天和出生后第一周之间，CTF1 缺乏导致小鼠脊髓和脑干核中运动神经元细胞死亡增加。此外，CT-1 是一种肝细胞存活因子，可有效减少急性肝损伤动物模型中的肝细胞损伤。心肌营养因子 1 的表达在缺氧刺激后增强，当在模拟缺血之前或在模拟缺血后的复氧时添加时，它可以保护心肌细胞。 Cardiotrophin 1 可以诱导心脏细胞中保护性热休克蛋白的表达。
Cardiotrophin-1 增加 ANP、脑利钠肽和血管紧张素原 mRNA 的心室表达。
Cardiophin 1 水平在心力衰竭患者、扩张型心肌病患者、中/重度二尖瓣关闭不全、稳定和不稳定型心绞痛患者以及急性心肌梗死后显着升高。

Description

CTF1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 202 amino acids and having a molecular mass of 21.3kDa.
The CTF1 Mouse is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CTF1 小鼠重组体是一条单一的、非糖基化的多肽链，含有 202 个氨基酸，分子量为 21.3kDa。
CTF1 Mouse 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CTF1 in sterile 4mM HCl to a concentration of 0.1-0.5 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-200C. Further dilutions should be made in appropriate buffered solutions.

Stability

Lyophilized CTF1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CTF1 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.
冻干的 CTF1 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CTF1 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
请防止冻融循环。

Purity

Greater than 98.0% as determined by -PAGE.

Amino acid sequence

SQREGSLEDH QTDSSISFLP HLEAKIRQTH NLARLLTKYA EQLLEEYVQQ QGEPFGLPGF SPPRLPLAGL SGPAPSHAGL PVSERLRQDA AALSVLPALL DAVRRRQAEL NPRAPRLLRS LEDAARQVRA LGAAVETVLA ALGAAARGPG PEPVTVATLF TANSTAGIFS AKVLGFHVCG LYGEWVSRTE GDLGQLVPGG VA

Biological Activity

The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0ng/ml, corresponding to a specific activity of > 1,000,000units/mg.
由 TF-1 细胞的剂量依赖性增殖确定的 ED50 < 1.0ng/ml，对应于 > 1,000,000units/mg 的比活性。

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CTF1 Human, His
  • CTF1 Human
  • CTF1 Rat

ProSpec-CTF1 Rat/CYT-199,Cardiotrophin-1 Rat Recombinant

ProSpec-CTF1 Rat/CYT-199,Cardiotrophin-1 Rat Recombinant,心肌营养素 1 是白细胞介素 6 超家族的 201 个氨基酸成员。它是通过其在心肌细胞中诱导肥大反应的能力来确定的。 CT-1 mRNA 水平在心肌细胞和心脏非心肌细胞中均存在。

CTF1 Rat

Cardiotrophin-1 Rat Recombinant
CYT-199
ProSpec-CTF1 Rat/CYT-199 2µg
ProSpec-CTF1 Rat/CYT-199 10µg
ProSpec-CTF1 Rat/CYT-199 1mg

Catalogue number

CYT-199

Synonyms

Cardiotrophin-1, CT-1, Ctf1.

Introduction

Cardiotrophin 1 is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes.
CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. Cardiotrophin 1 can induce expression of the protective heat shock proteins in cardiac cells.
Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide and angiotensinogen mRNA.
Cardiophin 1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction.
心肌营养素 1 是白细胞介素 6 超家族的 201 个氨基酸成员。它是通过其在心肌细胞中诱导肥大反应的能力来确定的。 CT-1 mRNA 水平在心肌细胞和心脏非心肌细胞中均存在。 CT 1 在正常成人肺中也大量检测到，并在胎儿和成人气道平滑肌细胞中表达。 CT 1 激活 gp130 依赖性信号传导并刺激 Janus 激酶/信号转导和转录途径激活因子，以转导心肌细胞中的肥大和细胞保护信号。
CT 1 还具有神经营养功能。在胚胎第 14 天和出生后第一周之间，CTF1 缺乏导致小鼠脊髓和脑干核中运动神经元细胞死亡增加。此外，CT-1 是一种肝细胞存活因子，可有效减少急性肝损伤动物模型中的肝细胞损伤。心肌营养因子 1 的表达在缺氧刺激后增强，当在模拟缺血之前或在模拟缺血后的复氧时添加时，它可以保护心肌细胞。 Cardiotrophin 1 可以诱导心脏细胞中保护性热休克蛋白的表达。
Cardiotrophin-1 增加 ANP、脑利钠肽和血管紧张素原 mRNA 的心室表达。
Cardiophin 1 水平在心力衰竭患者、扩张型心肌病患者、中/重度二尖瓣关闭不全、稳定和不稳定型心绞痛患者以及急性心肌梗死后显着升高。

Description

Cardiotrophin-1 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 203 amino acids and having a molecular mass of 21.4kDa.
The CTF1 Rat is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 Cardiotrophin-1 Rat Recombinant 是一种单一的、非糖基化的多肽链，含有 203 个氨基酸，分子量为 21.4kDa。
CTF1 大鼠通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Solubility

It is recommended to reconstitute the lyophilized CTF1 in sterile 4mM HCl not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议在不低于 100µg/ml 的无菌 4mM HCl 中复溶冻干的 CTF1，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized Cardiotrophin-1 Rat although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CTF1 Rat should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.
冻干的 Cardiotrophin-1 大鼠虽然在室温下稳定 3 周，但应在 -18°C 以下干燥储存。 重组后，CTF1 大鼠应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
请防止冻融循环。

Purity

Greater than 95.0% as determined by -PAGE and HPLC analyses.

Amino acid sequence

MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG GVA.

Biological Activity

The ED50 as determined by the dose-dependent proliferation of TF-1 cells was found to be < 0.5ng/ml, corresponding to a specific activity of > 2.0×106 units/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • CTF1 Human
  • CTF1 Human, His
  • CTF1 Mouse

ProSpec-CTF2P Mouse/CYT-1128

ProSpec CTF2P Mouse,ProSpec CYT-1128,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,The ED50 as determined by a cell proliferation assay using human TF-1 cells is < 200 ng/ml, corresponding to a specific activity of > 5000 IU/mg.

CTF2P Mouse

Neuropoietin Mouse Recombinant
CYT-1128
ProSpec-CTF2P Mouse/CYT-1128 50µg
ProSpec-CTF2P Mouse/CYT-1128 100µg
ProSpec-CTF2P Mouse/CYT-1128 1mg

Catalogue number

CYT-1128

Synonyms

Cardiotrophin-2, CT-2, Neuropoietin, Np, Ctf2, Gm494.

Introduction

CTF2P, aka Neuropoietinis a part of the IL-6 family of cytokines. CTF2P is the outcome of a gene duplication event involving cardiotrophin-1 and it helps to define a subfamily within the IL-6 family that includes CT-1, CLC and CTNF. CTF2P Increases the platelet count associated with splenomegaly and takes part in neuronal precursor development and maturation.

CTF2P，又名 Neuropoietinis，是 IL-6 细胞因子家族的一部分。 CTF2P 是涉及心肌营养因子-1 的基因复制事件的结果，它有助于在 IL-6 家族中定义一个亚家族，包括 CT-1、CLC 和 CTNF。 CTF2P 增加与脾肿大相关的血小板计数并参与神经元前体发育和成熟。

Description

Neuropoietin Mouse Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of approximately 19.7kDa.
CTF2P is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Neuropoietin Mouse Recombinant 是一种非糖基化多肽链，含有 182 个氨基酸，分子量约为 19.7kDa。
CTF2P 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 20mM Tris-HCl, pH 8.0, 0.5mM DTT and 500mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized Neuropoietin in sterile PBS not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的神经生成素在不低于 100μg/ml 的无菌 PBS 中复溶，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized CTF2P although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Neuropoietin should be stored at 4°C between 2-7 days and for future use below -18°C.

冻干的 CTF2P 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，Neuropoietin 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

Please prevent freeze-thaw cycles.

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

APISPSEPIG QAYSLALYMQ KNTSALLQTY LQHQGSPFSD PGFSAPELQL STLPSAAVSF KTWHAMEDAE RLSRAQGAFL ALTQHLQLVG DDQSYLNPGS PILLAQLGAA RLRAQGLLGN MAAIMTALGL PIPPEEDTLG FVPFGASAFE RKCRGYIVTR EYGHWTDRAV RDLALLKAKY SA.

Biological Activity

The ED50 as determined by a cell proliferation assay using human TF-1 cells is < 200 ng/ml, corresponding to a specific activity of > 5000 IU/mg.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

ProSpec-CTLA 4 Human/CYT-366

ProSpec CTLA 4 Human,ProSpec CYT-366,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,The CTLA 4 solution contains 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

CTLA 4 Human

Cytotoxic T-Lymphocyte Associated Antigen-4 Human Recombinant
CYT-366
ProSpec-CTLA 4 Human/CYT-366 5µg
ProSpec-CTLA 4 Human/CYT-366 25µg
ProSpec-CTLA 4 Human/CYT-366 1mg

Catalogue number

CYT-366

Synonyms

GSE, CD152, IDDM12, CELIAC3, CTLA-4.

Introduction

CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
CTLA-4 是免疫球蛋白超家族的成员，编码一种将抑制信号传递给 T 细胞的蛋白质。 该蛋白质包含一个V结构域、一个跨膜结构域和一个胞质尾。 已经表征了编码不同同种型的替代转录剪接变体。 膜结合异构体作为通过二硫键互连的同二聚体发挥作用，而可溶异构体作为单体发挥作用。 该基因的突变与胰岛素依赖型糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻、系统性红斑狼疮、甲状腺相关眼眶病和其他自身免疫性疾病有关。

Description

CTLA 4 Human Recombinant produced in E. coli is a single polypeptide chain containing 149 amino acids and having a molecular mass of 15.9 kDa.
CTLA 4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The CTLA 4 solution contains 20mM Tris-HCl buffer , 0.4M urea and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • CTLA 4 Antibody
  • CTLA4 Human, Sf9
  • CTLA4 Mouse
  • CTLA4 Antibody
  • CTLA4 Human, igG-His
  • CTLA4 Human, IgG-His, Active

ProSpec-CTLA4 Human, igG-His/CYT-985

ProSpec CTLA4 Human igG-His,ProSpec CYT-985,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,在 Sf9 杆状病毒细胞中产生的 CTLA4 是单条糖基化多肽链，包含 368 个氨基酸，分子量为 40.8kDa。CTLA4 在 C 末端用 239 个氨基酸的 hIgG-His-tag 表达，并通过专有色谱技术进行纯化。

CTLA4 Human, igG-His

Cytotoxic T-Lymphocyte Associated Antigen-4 Human Recombinant, igG-His Tag
CYT-985
ProSpec-CTLA4 Human, igG-His/CYT-985 2µg
ProSpec-CTLA4 Human, igG-His/CYT-985 10µg
ProSpec-CTLA4 Human, igG-His/CYT-985 1mg

Catalogue number

CYT-985

Synonyms

CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, CD152, Cytotoxic T-Lymphocyte Associated Antigen-4, igG-His Tag.

Introduction

CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
CTLA-4 是免疫球蛋白超家族的成员，编码一种将抑制信号传递给 T 细胞的蛋白质。 该蛋白质包含一个V结构域、一个跨膜结构域和一个胞质尾。 已经表征了编码不同同种型的替代转录剪接变体。 膜结合异构体作为通过二硫键互连的同二聚体发挥作用，而可溶异构体作为单体发挥作用。 该基因的突变与胰岛素依赖型糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻、系统性红斑狼疮、甲状腺相关眼眶病和其他自身免疫性疾病有关。

Description

CTLA4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 368 amino acids and having a molecular mass of 40.8kDa .
CTLA4 is expressed with a 239 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CTLA4 是单条糖基化多肽链，包含 368 个氨基酸，分子量为 40.8kDa。
CTLA4 在 C 末端用 239 个氨基酸的 hIgG-His-tag 表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CTLA4 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • CTLA 4 Human
  • CTLA4 Mouse
  • CTLA4 Human, Sf9
  • CTLA4 Human, IgG-His, Active

ProSpec-CTLA4 Human, IgG-His, Active/CYT-1144

ProSpec CTLA4 Human IgG-His Active,ProSpec CYT-1144,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,用 Jurkat 人急性 T 细胞白血病细胞通过 IL-2 ELISA 测定。 ED50 范围为 ≤ 150 ng/ml，人 B7 1/CD80。

CTLA4 Human, IgG-His, Active

CTLA4 Human Recombinant, igG-His Tag, Active
CYT-1144
ProSpec-CTLA4 Human, IgG-His, Active/CYT-1144 10µg
ProSpec-CTLA4 Human, IgG-His, Active/CYT-1144 50µg
ProSpec-CTLA4 Human, IgG-His, Active/CYT-1144 1mg

Catalogue number

CYT-1144

Synonyms

CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, CD152, Cytotoxic T-Lymphocyte Associated Antigen-4, igG-His Tag.

Introduction

Cytotoxic T-lymphocyte-associated protein 4 or CTLA4 or CD152 is a receptor that takes part in the immune checkpoint and inhibits immune response. This protein is fundamentally found in regulatory T cells; however, it acts as an enhancer in regular T cells following its activation, this is eminent in cancers. CTLA4 bounds to CD80 or CD86 on the membrane of antigen presenting cells and downregulates transductions.

细胞毒性 T 淋巴细胞相关蛋白 4 或 CTLA4 或 CD152 是一种参与免疫检查点并抑制免疫反应的受体。 这种蛋白质基本上存在于调节性 T 细胞中。 然而，它在被激活后作为常规 T 细胞的增强剂，这在癌症中是显着的。 CTLA4 与抗原呈递细胞膜上的 CD80 或 CD86 结合并下调转导。

Description

CTLA4 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 368 amino acids and having a molecular mass of 40.8kDa.
CTLA4 is fused to a 242 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CTLA4 Human 是一条糖基化多肽链，包含 368 个氨基酸，分子量为 40.8kDa。
CTLA4 在 C 末端与 242 个氨基酸的 hIgG-His-Tag 融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CTLA4 solution contains 10% Glycerol and Phosphate-Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Biological Activity

Determined by the IL-2 ELISA in a using Jurkat human acute T cell leukemia cells.  ED50 range for this is ≤ 150 ng/ml with Human B7 1/CD80.

用 Jurkat 人急性 T 细胞白血病细胞通过 IL-2 ELISA 测定。 ED50 范围为 ≤ 150 ng/ml，人 B7 1/CD80。

Amino acid sequence

ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG
NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI
DPEPCPDSDL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD
VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN
KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG
QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CTLA 4 Human
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ProSpec-EBI3 Human, His/CYT-668

ProSpec EBI3 Human, His,ProSpec CYT-668,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,EBI3 在对 Epstein-Barr 病毒感染作出反应的 B 淋巴细胞中具有诱导表达。 EBI3 编码一种属于造血素受体家族的分泌糖蛋白，并与 28 kDa 蛋白异二聚化形成 iIL-27。 EBI3 驱动幼稚 cd4 t 细胞的快速克隆扩增。 EBI3 与 IL-12 强烈协同作用以激活幼稚 cd4 t 细胞的 IFN-γ 产生。 EBI3 通过细胞因子受体 wsx-1/tccr 介导其生物学效应。

EBI3 Human, His

Epstein Barr Virus Induced 3 Human Recombinant, His Tag
CYT-668
ProSpec-EBI3 Human, His/CYT-668 2µg
ProSpec-EBI3 Human, His/CYT-668 10µg
ProSpec-EBI3 Human, His/CYT-668 1mg

Catalogue number

CYT-668

Synonyms

Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, EBI3, IL27B.

Introduction

EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4 t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4 t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.
EBI3 在对 Epstein-Barr 病毒感染作出反应的 B 淋巴细胞中具有诱导表达。 EBI3 编码一种属于造血素受体家族的分泌糖蛋白，并与 28 kDa 蛋白异二聚化形成 iIL-27。 EBI3 驱动幼稚 cd4 t 细胞的快速克隆扩增。 EBI3 与 IL-12 强烈协同作用以激活幼稚 cd4 t 细胞的 IFN-γ 产生。 EBI3 通过细胞因子受体 wsx-1/tccr 介导其生物学效应。

Description

EBI3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 209 amino acids fragment having a molecular weight of 34kDa and fused with a 4.5kDa amino-terminal hexahistidine tag.
The EBI3 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 EBI3 Human Recombinant 是一个单一的、非糖基化的多肽链，包含 209 个氨基酸片段，分子量为 34kDa，并与 4.5kDa 氨基末端六组氨酸标签融合。
EBI3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

EBI3 protein is supplied in 1xPBS, 50% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
请避免冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • EBI3 Human
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ProSpec-EBI3 Macaque/CYT-1036

ProSpec EBI3 Macaque,ProSpec CYT-1036,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,EBI3 在对 Epstein-Barr 病毒感染作出反应的 B 淋巴细胞中具有诱导表达。 EBI3 编码一种属于造血素受体家族的分泌糖蛋白，并与 28 kDa 蛋白异二聚化形成 iIL-27。

EBI3 Macaque

Epstein Barr Virus Induced 3 Macaque Recombinant
CYT-1036
ProSpec-EBI3 Macaque/CYT-1036 5µg
ProSpec-EBI3 Macaque/CYT-1036 20µg
ProSpec-EBI3 Macaque/CYT-1036 1mg

Catalogue number

CYT-1036

Synonyms

IL-27B, IL27B, IL 27-B, EBI-3, Interleukin-27 beta, IL-27 subunit beta, Epstein-Barr virus-induced gene 3 protein homolog, EBI3.

Introduction

EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4 t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4 t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.

EBI3 在对 Epstein-Barr 病毒感染作出反应的 B 淋巴细胞中具有诱导表达。 EBI3 编码一种属于造血素受体家族的分泌糖蛋白，并与 28 kDa 蛋白异二聚化形成 iIL-27。 EBI3 驱动幼稚 cd4 t 细胞的快速克隆扩增。 EBI3 与 IL-12 强烈协同作用以激活幼稚 cd4 t 细胞的 IFN-γ 产生。 EBI3 通过细胞因子受体 wsx-1/tccr 介导其生物学效应。

Description

EBI3 Macaque Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids and having a molecular mass of 23.4kDa. The EBI3 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 EBI3 Macaque Recombinant 是一条单一的、非糖基化的多肽链，包含 210 个氨基酸，分子量为 23.4kDa。 EBI3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a sterile filtered solution containing 0.1 % trifluoroacetic acid .

Solubility

It is recommended to reconstitute the lyophilized EBI3 in sterile 18MΩ-cm H2O at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在无菌 18MΩ-cm H2O 中以 100µg/ml 的浓度重构冻干的 EBI3，然后可以将其进一步稀释成其他水溶液。

Stability

Lyophilized EBI3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EBI3 Macaque should be stored at 4°C between 2-7 days and for future use below -18°C.

For long term storage it is recommended to add a carrier protein .

冻干的 EBI3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重新配制后，EBI3 Macaque 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

对于长期储存，建议添加载体蛋白。

Please prevent freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

MRKGPPAALT LPRVQCRAPR YPIAVDCSWT LPPAPNSTSP VSFIATYRFG MAARGHSWPC LQQTPASTSC TIADVRLFSM APYVLNVTAV HPWGSSSSFV PFIAEHIIKP DPPEGVRLSP LAERQLQVQW EPPRSWPFPE IFSLKYWIRY KRQGAARFHQ VGPIEATSFI LRAVRPRARY CVQVAAQDLT DYGELSDWSL PATTPMSPGK.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • EBI3 Human
  • EBI3 Mouse
  • EBI3 Human, His

ProSpec-EBI3 Mouse/CYT-621

ProSpec EBI3 Mouse,ProSpec CYT-621,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,冻干的 EBI3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，EBI3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

EBI3 Mouse

Epstein Barr Virus Induced 3 Mouse Recombinant
CYT-621
ProSpec-EBI3 Mouse/CYT-621 2µg
ProSpec-EBI3 Mouse/CYT-621 10µg
ProSpec-EBI3 Mouse/CYT-621 1mg

Catalogue number

CYT-621

Synonyms

IL-27B, IL27B, IL 27-B, EBI-3, Interleukin-27 beta, IL-27 subunit beta, Epstein-Barr virus-induced gene 3 protein homolog, EBI3.

Introduction

EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4 t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4 t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.
EBI3 在对 Epstein-Barr 病毒感染作出反应的 B 淋巴细胞中具有诱导表达。 EBI3 编码一种属于造血素受体家族的分泌糖蛋白，并与 28 kDa 蛋白异二聚化形成 iIL-27。 EBI3 驱动幼稚 cd4 t 细胞的快速克隆扩增。 EBI3 与 IL-12 强烈协同作用以激活幼稚 cd4 t 细胞的 IFN-γ 产生。 EBI3 通过细胞因子受体 wsx-1/tccr 介导其生物学效应。

Description

EBI3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids and having a molecular mass of 22.9kDa.
The Murine EBI3 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 EBI3 Mouse Recombinant 是一条单一的、非糖基化的多肽链，包含 207 个氨基酸，分子量为 22.9kDa。
Murine EBI3 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

EBI3 was lyophilized from 10mM Sodium Citrate pH-3.

Solubility

It is recommended to reconstitute the lyophilized EBI3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干的 EBI3，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized EBI3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EBI3 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.
冻干的 EBI3 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，EBI3 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
请防止冻融循环。

Purity

Greater than 90% as determined by Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

MALVALSQPR VQCHASRYPV AVDCSWTPLQ APNSTRSTSF IATYRLGVAT QQQSQPCLQR SPQASRCTIP DVHLFSTVPY MLNVTAVHPG GASSSLLAFV AERIIKPDPP EGVRLRTAGQ RLQVLWHPPA SWPFPDIFSL KYRLRYRRRG ASHFRQVGPI EATTFTLRNS KPHAKYCIQV SAQDLTDYGK PSDWSLPGQV ESAPHKP.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • EBI3 Human, His
  • EBI3 Human
  • EBI3 Macaque

ProSpec-Endoglin (27-581) Mouse/CYT-972

ProSpec Endoglin (27-581) Mouse,ProSpec CYT-972,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。对于长期储存，建议添加载体蛋白。避免多次冻融循环。

Endoglin Mouse

Endoglin Mouse Recombinant
CYT-972
ProSpec-Endoglin (27-581) Mouse/CYT-972 1µg
ProSpec-Endoglin (27-581) Mouse/CYT-972 5µg
ProSpec-Endoglin (27-581) Mouse/CYT-972 50µg

Catalogue number

CYT-972

Synonyms

Endoglin, Cell surface MJ7/18 antigen, CD105, Eng, Edg.

Introduction

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.
The Endoglin protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Endoglin has been found to be part of the TGF-beta1 receptor complex. Endoglin thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Endoglin expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.
Endoglin 是一种位于细胞表面的 I 型膜糖蛋白，是 TGF β 受体复合物的一部分。
Endoglin 蛋白由具有二硫键的 180 kDA 同源二聚体组成。 已在内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上发现内皮糖蛋白。 此外，已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。 因此，内皮糖蛋白可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。 除了 TGF-β 信号转导内皮糖蛋白可能还有其他功能。 据推测，内皮糖蛋白参与影响细胞形态和迁移的细胞骨架组织。 Endoglin 在心血管系统的发育和血管重塑中发挥作用。 内皮糖蛋白的表达在心脏发育过程中受到调节。 没有内皮糖蛋白基因的实验小鼠因心血管异常而死亡。

Description

Endoglin Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 563 amino acids and having a molecular mass of 60.9kDa .
Endoglin is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 Endoglin Mouse Recombinant 是单条糖基化多肽链，包含 563 个氨基酸，分子量为 60.9kDa。
Endoglin 在 C 末端用 8 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

Endoglin protein solution containing Phosphate Buffered Saline and 10% glycerol.
含有磷酸盐缓冲液和 10% 甘油的内皮糖蛋白溶液。

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。对于长期储存，建议添加载体蛋白。避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

ERVGCDLQPV DPTRGEVTFT TSQVSEGCVA QAANAVREVH VLFLDFPGML SHLELTLQAS KQNGTETQEV FLVLVSNKNV FVKFQAPEIP LHLAYDSSLV IFQGQPRVNI TVLPSLTSRK QILDWAATKG AITSIAALDD PQSIVLQLGQ DPKAPFLCLP EAHKDMGATL EWQPRAQTPV QSCRLEGVSG HKEAYILRIL PGSEAGPRTV TVMMELSCTS GDAILILHGP PYVSWFIDIN HSMQILTTGE YSVKIFPGSK VKGVELPDTP QGLIAEARKL NASIVTSFVE LPLVSNVSLR ASSCGGVFQT TPAPVVTTPP KDTCSPVLLM SLIQPKCGNQ VMTLALNKKH VQTLQCTITG LTFWDSSCQA EDTDDHLVLS SAYSSCGMKV TAHVVSNEVI ISFPSGSPPL RKKVQCIDMD SLSFQLGLYL SPHFLQASNT IELGQQAFVQ VSVSPLTSEV TVQLDSCHLD LGPEGDMVEL IQSRTAKGSC VTLLSPSPEG DPRFSFLLRV YMVPTPTAGT LSCNLALRPS TLSQEVYKTV SMRLNIVSPD LSGKGLEHHH HHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • Endoglin Human, His
  • Endoglin Human
  • Endoglin Human, Sf9
  • Endoglin Mouse

ProSpec-Endoglin Human/CYT-525

ProSpec Endoglin Human,ProSpec CYT-525,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Endoglin 蛋白由具有二硫键的 180 kDA 同源二聚体组成。 已在内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上发现内皮糖蛋白。 此外，已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。 因此，内皮糖蛋白可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。

Endoglin Human
Endoglin Human Recombinant
CYT-525
ProSpec-Endoglin Human/CYT-525 2µg
ProSpec-Endoglin Human/CYT-525 5µg
ProSpec-Endoglin Human/CYT-525 10µg

Catalogue number

CYT-525

Synonyms

CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin.

Introduction

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.
The Endoglin protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Endoglin has been found to be part of the TGF-beta1 receptor complex. Endoglin thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Endoglin expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.
Endoglin 是一种位于细胞表面的 I 型膜糖蛋白，是 TGF β 受体复合物的一部分。
Endoglin 蛋白由具有二硫键的 180 kDA 同源二聚体组成。 已在内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上发现内皮糖蛋白。 此外，已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。 因此，内皮糖蛋白可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。 除了 TGF-β 信号转导内皮糖蛋白可能还有其他功能。 据推测，内皮糖蛋白参与影响细胞形态和迁移的细胞骨架组织。 Endoglin 在心血管系统的发育和血管重塑中发挥作用。 内皮糖蛋白的表达在心脏发育过程中受到调节。 没有内皮糖蛋白基因的实验小鼠因心血管异常而死亡。

Description

Endoglin Human Recombinant extracellular domain produced in E.Coli is a single, glycosylated, Polypeptide containing 151 amino acids and having a molecular mass of 43 kDa.
The Endoglin is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 Endoglin Human Recombinant 胞外结构域是一种单一的糖基化多肽，含有 151 个氨基酸，分子量为 43 kDa。
Endoglin 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless liquid formulation.

Formulation

Endoglin solution in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • Endoglin Mouse
  • Endoglin Human, Sf9
  • Endoglin Human, His
  • Endoglin Mouse

ProSpec-Endoglin Human, His/CYT-823

ProSpec Endoglin Human His,ProSpec CYT-823,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,The Endoglin solution contains 20mM Tris-HCl buffer , 1mM DTT, 150mM NaCl and 10% glycerol.

Endoglin Human, His

Endoglin Human Recombinant, His-Tag
CYT-823
ProSpec-Endoglin Human, His/CYT-823 2µg
ProSpec-Endoglin Human, His/CYT-823 10µg
ProSpec-Endoglin Human, His/CYT-823 100µg

Catalogue number

CYT-823

Synonyms

CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin.

Introduction

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.
The Endoglin protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Endoglin has been found to be part of the TGF-beta1 receptor complex. Endoglin thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Endoglin expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.
Endoglin 是一种位于细胞表面的 I 型膜糖蛋白，是 TGF β 受体复合物的一部分。
Endoglin 蛋白由具有二硫键的 180 kDA 同源二聚体组成。 已在内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上发现内皮糖蛋白。 此外，已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。 因此，内皮糖蛋白可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。 除了 TGF-β 信号转导内皮糖蛋白可能还有其他功能。 据推测，内皮糖蛋白参与影响细胞形态和迁移的细胞骨架组织。 Endoglin 在心血管系统的发育和血管重塑中发挥作用。 内皮糖蛋白的表达在心脏发育过程中受到调节。 没有内皮糖蛋白基因的实验小鼠因心血管异常而死亡。

Description

Endoglin Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 594 amino acids and having a molecular mass of 64.9 kDa. Endoglin is fused to a 36 amino acid His-tag at N-terminus.
在大肠杆菌中产生的 Endoglin Human Recombinant 是一条含有 594 个氨基酸且分子量为 64.9 kDa 的单一非糖基化多肽链。 Endoglin 在 N 端与 36 个氨基酸的 His 标签融合。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The Endoglin solution contains 20mM Tris-HCl buffer , 1mM DTT, 150mM NaCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSETVH CDLQPVGPER DEVTYTTSQV SKGCVAQAPN AILEVHVLFL EFPTGPSQLE LTLQASKQNG TWPREVLLVL SVNSSVFLHL QALGIPLHLA YNSSLVTFQE PPGVNTTELP SFPKTQILEW AAERGPITSA AELNDPQSIL LRLGQAQGSL SFCMLEASQD MGRTLEWRPR TPALVRGCHL EGVAGHKEAH ILRVLPGHSA GPRTVTVKVE LSCAPGDLDA VLILQGPPYV SWLIDANHNM QIWTTGEYSF KIFPEKNIRG FKLPDTPQGL LGEARMLNAS IVASFVELPL ASIVSLHASS CGGRLQTSPA PIQTTPPKDT CSPELLMSLI QTKCADDAMT LVLKKELVAH LKCTITGLTF WDPSCEAEDR GDKFVLRSAY SSCGMQVSAS MISNEAVVNI LSSSSPQRKK VHCLNMDSLS FQLGLYLSPH FLQASNTIEP GQQSFVQVRV SPSVSEFLLQ LDSCHLDLGP EGGTVELIQG RAAKGNCVSL LSPSPEGDPR FSFLLHFYTV PIPKTGTLSC TVALRPKTGS QDQEVHRTVF MRLNIISPDL SGCTSKG

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Endoglin Human
  • Endoglin Mouse
  • Endoglin Mouse
  • Endoglin Human, Sf9

ProSpec-Endoglin Human, Sf9/CYT-389

ProSpec Endoglin Human Sf9,ProSpec CYT-389,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin.

Endoglin Human, Sf9

Endoglin Human Recombinant, Sf9
CYT-389
ProSpec-Endoglin Human, Sf9/CYT-389 2µg
ProSpec-Endoglin Human, Sf9/CYT-389 10µg
ProSpec-Endoglin Human, Sf9/CYT-389 100µg

Catalogue number

CYT-389

Synonyms

CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin.

Introduction

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.
The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.
Endoglin 是一种位于细胞表面的 I 型膜糖蛋白，是 TGF β 受体复合物的一部分。
该蛋白质由具有二硫键的 180 kDA 同型二聚体组成。 它存在于内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上。 已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。 因此它可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。 除了 TGF-β 信号转导内皮糖蛋白可能还有其他功能。 据推测，内皮糖蛋白参与影响细胞形态和迁移的细胞骨架组织。 Endoglin 在心血管系统的发育和血管重塑中发挥作用。 它的表达在心脏发育过程中受到调节。 没有内皮糖蛋白基因的实验小鼠因心血管异常而死亡。

Description

CD105 Human Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, Polypeptide containing 586 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 90 kDa under reducing conditions in -PAGE. The CD105 is fused to a C-terminal His-tag and purified by proprietary chromatographic techniques.
杆状病毒中产生的 CD105 人重组细胞外结构域是一种同型二聚体、糖基化多肽，包含 586 个氨基酸，分子量为 61 kDa，但由于糖基化，在 -PAGE 的还原条件下以 90 kDa 迁移。 CD105 与 C 末端 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9 Insect Cells.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Endoglin was lyophilized from a concentrated sterile solution containing 1xPBS.

Solubility

It is recommended to reconstitute the lyophilized CD-105 in sterile PBS not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议将冻干的 CD-105 溶解在不低于 100µg/ml 的无菌 PBS 中，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized Endoglin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD105 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 Endoglin 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，CD105 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTY TTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVL SVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPI TSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLE GVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLID ANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPL ASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKE LVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNI LSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSE FLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPI PKTGTLSCTVALRPKTGS.

Biological Activity

Measured by its ability to bind with rhTGF-beta RII/Fc in a functional ELISA. Optimal dilutions should be determined by each laboratory for each application.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • Endoglin Mouse
  • Endoglin Human
  • Endoglin Mouse
  • Endoglin Human, His

ProSpec-EREG Human/CYT-609

ProSpec-EREG Human,ProSpec CYT-609,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,在大肠杆菌中产生的 Epiregulin Human Recombinant 是单一的、非糖基化的多肽链，包含 49 个氨基酸，分子量为 5.6 kDa。上皮调节蛋白通过专有的色谱技术进行纯化。

EREG Human

Epiregulin Human Recombinant
CYT-609
ProSpec-EREG Human/CYT-609 5µg
ProSpec-EREG Human/CYT-609 25µg
ProSpec-EREG Human/CYT-609 1mg

Catalogue number

CYT-609

Synonyms

EREG, Epiregulin, ER.

Introduction

Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB family of tyrosine-kinase receptors.Epiregulin is expressed mostly in the placenta and peripheral blood leukocytes and in specific carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. Epiregulin inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
上皮调节蛋白是 EGF 家族的一部分。 上皮调节蛋白作为 EGFR 的配体，以及酪氨酸激酶受体 ERBB 家族大多数成员的配体。上皮调节蛋白主要在胎盘和外周血白细胞以及膀胱、肺、肾和结肠的特定癌中表达 . 上皮调节蛋白刺激角质形成细胞、肝细胞、成纤维细胞和血管平滑肌细胞的增殖。 Epiregulin 抑制几种肿瘤来源的上皮细胞系的生长。 人上皮调节蛋白最初合成为糖基化的 19.0 kDa 跨膜前体蛋白，通过蛋白水解切割加工产生 6.0 kDa 成熟分泌序列。

Description

Epiregulin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 49 amino acids and having a molecular mass of 5.6 kDa.
Epiregulin is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Epiregulin Human Recombinant 是单一的、非糖基化的多肽链，包含 49 个氨基酸，分子量为 5.6 kDa。
上皮调节蛋白通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Epiregulin was lyophilized from 0.5mg/ml solution ciontaing 20mM PBS buffer pH-7.4 containing 20mM sodium chloride.

Solubility

It is recommended to reconstitute the lyophilized Epiregulin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议将冻干的上皮调节蛋白在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized Epiregulin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Epiregulin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的上皮调节蛋白虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，上皮调节蛋白应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Biological Activity

The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is < 2.0 ng/ml, corresponding to a specific activity of > 500,000 units/mg.
通过对鼠 Balb/3T3 细胞增殖的剂量依赖性刺激确定 ED50 < 2.0 ng/ml，对应于 > 500,000 单位/mg 的比活性。

Purity

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

VAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • EREG Human, His

ProSpec-TNFSF14 Human/CYT-1202

ProSpec-TNFSF14 Human,ProSpec CYT-1202,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,TNFRSF14 是 TNF 受体超家族的成员，是一种 I 型跨膜蛋白。 TNFRSF14 在外周血 T 细胞、B 细胞、单核细胞和富含淋巴细胞的各种组织中表达。

ProSpec-TNFSF14 Human/CYT-1202

Catalogue number

CYT-1202

Synonyms

Tumor necrosis factor ligand superfamily member 14, CD258, Tnfsf14, Light

Introduction

TNFRSF14, a member of the TNF receptor superfamily, is a type I transmembrane protein. TNFRSF14 is expressed in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. TNFRSF14 operates as a co-stimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Additionally, TNFRSF14 encourages the proliferation of T cells, and triggers apoptosis of various tumor cells.

TNFRSF14 是 TNF 受体超家族的成员，是一种 I 型跨膜蛋白。 TNFRSF14 在外周血 T 细胞、B 细胞、单核细胞和富含淋巴细胞的各种组织中表达。 TNFRSF14 作为激活淋巴样细胞的共刺激因子和对疱疹病毒感染的威慑物起作用。 此外，TNFRSF14 促进 T 细胞的增殖，并引发各种肿瘤细胞的凋亡。

Description

Recombinant Human LIGHT having a Mw of 43kDa was purified from E. coli.
The Recombinant Human LIGHT is fused to GST tag at its N terminal and purified by proprietary chromatographic technique.

从大肠杆菌中纯化具有 43kDa 分子量的重组人 LIGHT。
Recombinant Human LIGHT 在其 N 末端与 GST 标签融合，并通过专有色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

TNFSF14 solution contains 25mM Tris-Base/ 25mM K2CO3.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Amino acid sequence

DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV

Purity

Protein is >95% pure as determined by 10% PAGE .

Applications

Immunoassay.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • TNFSF14 Mouse

ProSpec-TNFSF14 Mouse/CYT-826

ProSpec-TNFSF14 Mouse,ProSpec CYT-826,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,TNFRSF14 是 TNF 受体超家族的成员，是一种 I 型跨膜蛋白。 TNFRSF14 在外周血 T 细胞、B 细胞、单核细胞和富含淋巴细胞的各种组织中表达。

TNFSF14 Mouse

LIGHT Mouse Recombinant
CYT-826
ProSpec-TNFSF14 Mouse/CYT-826 5µg
ProSpec-TNFSF14 Mouse/CYT-826 20µg
ProSpec-TNFSF14 Mouse/CYT-826 1mg

Catalogue number

CYT-826

Synonyms

Tumor necrosis factor ligand superfamily member 14, CD258, Tnfsf14, Light.

Introduction

TNFRSF14, a member of the TNF receptor superfamily, is a type I transmembrane protein. TNFRSF14 is expressed in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. TNFRSF14 operates as a co-stimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Additionally, TNFRSF14 encourages the proliferation of T cells, and triggers apoptosis of various tumor cells.
TNFRSF14 是 TNF 受体超家族的成员，是一种 I 型跨膜蛋白。 TNFRSF14 在外周血 T 细胞、B 细胞、单核细胞和富含淋巴细胞的各种组织中表达。 TNFRSF14 作为激活淋巴样细胞的共刺激因子和对疱疹病毒感染的威慑物起作用。 此外，TNFRSF14 促进 T 细胞的增殖，并引发各种肿瘤细胞的凋亡。

Description

TNFSF14 Mouse Recombinant produced in E. Coli is a single, non-glycosylated, polypeptide chain containing 168 amino acids and having a molecular mass of 18.4kDa.
在大肠杆菌中产生的 TNFSF14 Mouse Recombinant 是一种单一的、非糖基化的多肽链，含有 168 个氨基酸，分子量为 18.4kDa。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

TNFSF14 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS pH7.4.

Solubility

It is recommended to reconstitute the lyophilized TNFSF14 in sterile 100mM HAc not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议将冻干的 TNFSF14 溶解在不低于 100µg/ml 的无菌 100mM HAc 中，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized TNFSF14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNFSF14 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 TNFSF14 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后 TNFSF14 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 96.0% as determined by:
Analysis by RP-HPLC.

Analysis by -PAGE.

Amino acid sequence

DGGKGSWEKL IQDQRSHQAN PAAHLTGANA SLIGIGGPLL WETRLGLAFL RGLTYHDGAL VTMEPGYYYV YSKVQLSGVG CPQGLANGLP ITHGLYKRTS RYPKELELLV SRRSPCGRAN SSRVWWDSSF LGGVVHLEAG EEVVVRVPGN RLVRPRDGTR SYFGAFMV.

Biological Activity

The ED50 as determined by a cytotoxicity assay using human HT-29 cells is less than 2µg/ml, corresponding to a specific activity of > 500 IU/mg in the presence of murine anti-polyHistidine monoclonal antibody and rHuIFN-g.
通过使用人 HT-29 细胞的细胞毒性测定法确定的 ED50 小于 2μg/ml，对应于在鼠抗多组氨酸单克隆抗体和 rHuIFN-g 存在下 > 500 IU/mg 的比活性。

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • TNFRSF14 Human, Sf9
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ProSpec-IL6ST Human/CYT-1156

ProSpec-IL6ST Human,ProSpec CYT-1156,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,在 Sf9 杆状病毒细胞中产生的 IL6ST Human 是单条糖基化多肽链，含有 605 个氨基酸，分子量为 68.9kDa。IL6ST 在 C 末端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

IL6ST Human
Interleukin-6 Signal Transducer Human Recombinant
CYT-1156
ProSpec-IL6ST Human/CYT-1156 1µg
ProSpec-IL6ST Human/CYT-1156 5µg
ProSpec-IL6ST Human/CYT-1156 50µg

Catalogue number

CYT-1156

Synonyms

Interleukin 6 signal transducer, oncostatin M receptor, IL6ST, CD130, CDw130, GP130, GP130-RAPS, IL6R-beta

Introduction

Interleukin-6 Signal Transducer or IL6ST is a receptor, part of the family of class 1 cytokine receptor. IL6ST binds to IL-6 through membrane-anchored or soluble IL-6R starts a connection between another complex of IL6ST and IL-6 , thus forming a homo-dimer and a signal transduction occurs.

Interleukin-6 Signal Transducer 或 IL6ST 是一种受体，是 1 类细胞因子受体家族的一部分。 IL6ST通过膜锚定或可溶性IL-6R与IL-6结合，启动IL6ST和IL-6的另一个复合物之间的连接，从而形成同源二聚体并发生信号转导。

Description

IL6ST Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 605 amino acids and having a molecular mass of 68.9kDa.
IL6ST is fused to an 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 IL6ST Human 是单条糖基化多肽链，含有 605 个氨基酸，分子量为 68.9kDa。
IL6ST 在 C 末端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The IL6ST solution contains 10% Glycerol and Phosphate-Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

ELLDPCGYIS PESPVVQLHS NFTAVCVLKE KCMDYFHVNA NYIVWKTNHF TIPKEQYTII NRTASSVTFT DIASLNIQLT CNILTFGQLE QNVYGITIIS GLPPEKPKNL SCIVNEGKKM RCEWDRGRET HLETNFTLKS EWATHKFADC KAKRDTPTSC TVDYSTVYFV NIEVWVEAEN ALGKVTSDHI NFDPVYKVKP NPPHNLSVIN SEELSSILKL TWTNPSIKSV IILKYNIQYR TKDASTWSQI PPEDTASTRS SFTVQDLKPF TEYVFRIRCM KEDGKGYWSD WSEEASGITY EDRPSKAPSF WYKIDPSHTQ GYRTVQLVWK TLPPFEANGK ILDYEVTLTR WKSHLQNYTV NATKLTVNLT NDRYVATLTV RNLVGKSDAA VLTIPACDFQ ATHPVMDLKA FPKDNMLWVE WTTPRESVKK YILEWCVLSD KAPCITDWQQ EDGTVHRTYL RGNLAESKCY LITVTPVYAD GPGSPESIKA YLKQAPPSKG PTVRTKKVGK NEAVLEWDQL PVDVQNGFIR NYTIFYRTII GNETAVNVDS SHTEYTLSSL TSDTLYMVRM AAYTDEGGKD GPEFTFTTPK FAQGEIELEH HHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

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ProSpec-NTRK2 Human/CYT-1159

ProSpec-NTRK2 Human,ProSpec CYT-1159,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines.神经营养受体酪氨酸激酶 2，也称为 NTRK2，是一种酪氨酸蛋白激酶受体，通过调节神经元存活、迁移、增殖、分化和突触形成，参与中枢和外周神经系统的发育和成熟。 可塑性。 NTRK2 通过调节短期突触功能和长期增强作用在学习和记忆中。 TRK 家族受体的已知底物是：SHC1、PI-3 激酶和 PLC-γ-1。

NTRK2 Human
Neurotrophic Receptor Tyrosine Kinase 2 Human Recombinant
CYT-1159
ProSpec-NTRK2 Human/CYT-1159 2µg
ProSpec-NTRK2 Human/CYT-1159 10µg
ProSpec-NTRK2 Human/CYT-1159 1mg

Catalogue number

CYT-1159

Synonyms

GP145-TrkB, trk-B, TRKB, NTRK2

Introduction

Neurotrophic Receptor Tyrosine Kinase 2, also referred to NTRK2, is a tyrosine-protein kinase receptor which takes part in the development & the maturation of the central and the peripheral nervous systems through regulation of neuron survival, migration, proliferation, differentiation and synapse formation & plasticity.  NTRK2 acts in learning and memory by regulating both short term synaptic function and long-term potentiation. The substrates that are known for the TRK family receptors are: SHC1, PI-3 kinase and PLC-gamma-1.

神经营养受体酪氨酸激酶 2，也称为 NTRK2，是一种酪氨酸蛋白激酶受体，通过调节神经元存活、迁移、增殖、分化和突触形成，参与中枢和外周神经系统的发育和成熟。 可塑性。 NTRK2 通过调节短期突触功能和长期增强作用在学习和记忆中。 TRK 家族受体的已知底物是：SHC1、PI-3 激酶和 PLC-γ-1。

Description

NTRK2 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 407 amino acids and having a molecular mass of 45.2kDa.
NTRK2 is fused to an 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 NTRK2 Human 是一条糖基化多肽链，包含 407 个氨基酸，分子量为 45.2kDa。
NTRK2 在 C 末端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The NTRK2 solution contains 10% Glycerol and Phosphate-Buffered Saline .

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 95% as determined by -PAGE.

Amino acid sequence

CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREHL EHHHHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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ProSpec-PECAM1 Human/CYT-924

ProSpec-PECAM1 Human,ProSpec CYT-924,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,在 Sf9 杆状病毒中产生的 PECAM1 Human Recombinant 是一个单一的、非糖基化的多肽链，含有 582 个氨基酸，分子量为 65.5kDa。PECAM1 在 C 端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

PECAM1 Human

Platelet Endothelial Cell Adhesion Molecule 1 Human Recombinant
CYT-924
ProSpec-PECAM1 Human/CYT-924 2µg
ProSpec-PECAM1 Human/CYT-924 10µg
ProSpec-PECAM1 Human/CYT-924 1mg

Catalogue number

CYT-924

Synonyms

Platelet endothelial cell adhesion molecule, PECAM1, CD31, CD31/EndoCAM, endoCAM, GPIIA’, PECA1, PECAM-1, Platelet Endothelial Cell Adhesion Molecule 1.
血小板内皮细胞粘附分子、PECAM1、CD31、CD31/EndoCAM、endoCAM、GPIIA’、PECA1、PECAM-1、血小板内皮细胞粘附分子 1。

Introduction

Platelet endothelial cell adhesion molecule induces susceptibility to atherosclerosis. PECAM1 averts phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and transforms function upon apoptosis, thus promoting tethering of dying cells to phagocytes. The encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces as a result causing the viable cell’s active repulsion from the phagocyte.
血小板内皮细胞粘附分子诱导动脉粥样硬化易感性。 PECAM1 通过传递分离信号来避免吞噬细胞摄入紧密并列的活细胞，并在细胞凋亡时转变功能，从而促进垂死细胞与吞噬细胞的结合。 通过 PECAM1 在两个细胞表面上的同源性相互作用，活细胞与吞噬细胞相遇，结果导致活细胞主动排斥吞噬细胞。

Description

PECAM1 Human Recombinant produced in Sf9 Baculovirus is a single, non-glycosylated polypeptide chain containing 582 amino acids and having a molecular mass of 65.5kDa .
PECAM1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒中产生的 PECAM1 Human Recombinant 是一个单一的、非糖基化的多肽链，含有 582 个氨基酸，分子量为 65.5kDa。
PECAM1 在 C 端与 8 个氨基酸的 His 标签融合，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

PECAM1 protein solution containing Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

QENSFTINSV DMKSLPDWTV QNGKNLTLQC FADVSTTSHV KPQHQMLFYK DDVLFYNISS MKSTESYFIP EVRIYDSGTY KCTVIVNNKE KTTAEYQVLV EGVPSPRVTL DKKEAIQGGI VRVNCSVPEE KAPIHFTIEK LELNEKMVKL KREKNSRDQN FVILEFPVEE QDRVLSFRCQ ARIISGIHMQ TSESTKSELV TVTESFSTPK FHISPTGMIM EGAQLHIKCT IQVTHLAQEF PEIIIQKDKA IVAHNRHGNK AVYSVMAMVE HSGNYTCKVE SSRISKVSSI VVNITELFSK PELESSFTHL DQGERLNLSC SIPGAPPANF TIQKEDTIVS QTQDFTKIAS KGTYICT AGIDKVVKKS NTVQIVVCEM LSQPRISYDA QFEVIKGQTI EVRCESISGT LPISYQLLKT SKVLENSTKN SNDPAVFKDN PTEDVEYQCV ADNCHSHAKM LSEVLRVKVI APVDEVQISI LSSKVVESGE DIVLQCAVNE GSGPITYKFY REKEGKPFYQ MTSNATQAFW TKQKASKEQE GEYYCTAFNR ANHASSVPRS KILTVRVILA PWKKVEHHHH HH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec-TAFA2 Human/CYT-118

ProSpec-TAFA2 Human,ProSpec CYT-118,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Family with sequence similarity 19 -like) member A2, Chemokine-like protein TAFA-2, protein FAM19A2.

TAFA2 Human

Family with Sequence Similarity 19 Member A2 Human Recombinant
CYT-118
ProSpec-TAFA2 Human/CYT-118 5µg
ProSpec-TAFA2 Human/CYT-118 20µg
ProSpec-TAFA2 Human/CYT-118 1mg

Catalogue number

CYT-118

Synonyms

Family with sequence similarity 19 -like) member A2, Chemokine-like protein TAFA-2, protein FAM19A2.

Introduction

TAFA-2 is a 11 kDa secreted protein that belongs to the FAM19/TAFA family of chemokine-like proteins. Similar to other FAM19/TAFA family members, mature TAFA-1 contains 10 regularly spaced cysteine residues with the same pattern: CX7CCX13CXCX14CX11CX4CX5CX10C . Human TAFA-2 is 97% aa identical to mouse TAFA-2 and is expressed in the central nervous system , colon, heart, lung, spleen, kidney, and thymus, however its expression in the CNS is 50 to 1000 fold higher than in other tissues. The biological roles of TAFA family members have not yet been determined.
TAFA-2 是一种 11 kDa 的分泌蛋白，属于趋化因子样蛋白的 FAM19/TAFA 家族。 与其他 FAM19/TAFA 家族成员类似，成熟的 TAFA-1 包含 10 个具有相同模式的规则间隔的半胱氨酸残基：CX7CCX13CXCX14CX11CX4CX5CX10C。 人 TAFA-2 与小鼠 TAFA-2 有 97% 的氨基酸相同，并在中枢神经系统、结肠、心脏、肺、脾、肾和胸腺中表达，但其在中枢神经系统中的表达比在中枢神经系统中高 50 至 1000 倍 其他组织。 TAFA 家族成员的生物学作用尚未确定。

Description

TAFA2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 101 amino acids and having a molecular mass of 11.2kDa.
The TAFA2 is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 TAFA2 Human Recombinant 是一种非糖基化的多肽链，含有 101 个氨基酸，分子量为 11.2kDa。
TAFA2 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

The protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH7.4.

Solubility

It is recommended to reconstitute the lyophilized TAFA2 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
建议将冻干的 TAFA2 溶解在不低于 100µg/ml 的无菌 18M-cm H2O 中，然后可以进一步稀释成其他水溶液。

Stability

Lyophilized TAFA2 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TAFA2 should be stored at 4C between 2-7 days and for future use below -18C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 TAFA2 虽然在室温下可稳定保存 3 周，但应在 -18C 以下干燥储存。 重组后，TAFA2 应在 4C 下储存 2-7 天，以备将来在 -18C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 97.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

ANHHKAHHVK TGTCEVVALH RCCNKNKIEE RSQTVKCSCF PGQVAGTTRA APSCVDASIV EQKWWCHMQP CLEGEECKVL PDRKGWSCSS GNKVKTTRVT H

Biological Activity

Fully biologically active when compared to standard. Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.