标签： MCP 4 Human

Small inducible cytokine A13, CCL13, Monocyte chemotactic protein 4, MCP-4, Monocyte chemoattractant protein 4, CK-beta-10, NCC-1, chemokine ligand 13, NCC1, CKb10, SCYL1, SCYA13, MGC17134.

Chemokine ligand 13 is a small cytokine belonging to the CC chemokine family. The MCP-4 gene is located on human chromosome 17 within a large cluster of other CC chemokines. MCP-4 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. Activity of the MCP-4 chemokine has been implicated in allergic reactions such as asthma. MCP-4 can be induced by the inflammatory cytokines interleukin-1 and TNF-a.

趋化因子配体 13 是属于 CC 趋化因子家族的小细胞因子。 MCP-4 基因位于一大群其他 CC 趋化因子内的人类 17 号染色体上。 MCP-4 通过结合细胞表面 G 蛋白连接的趋化因子受体（如 CCR2、CCR3 和 CCR5）在单核细胞、嗜酸性粒细胞、T 淋巴细胞和嗜碱性粒细胞中诱导趋化性。 MCP-4 趋化因子的活性与哮喘等过敏反应有关。 MCP-4 可被炎症细胞因子 IL-1 和 TNF-a 诱导。

Monocyte Chemotactic Protein-4 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 75 amino acids and having a molecular mass of 8.6 kDa. The MCP-4 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的单核细胞趋化蛋白 4 人重组体是一种非糖基化的多肽链，含有 75 个氨基酸，分子量为 8.6 kDa。 MCP-4 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

The protein was lyophilized from a concentrated sterile solution in 20mM PB, pH 7.4, 130mM NaCl.

It is recommended to reconstitute the lyophilized MCP-4 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized MCP-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MCP-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 96.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

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The specific activity as determined by the ability of MCP-4 to chemoattaract human monocytes at 10-100ng/ml, corresponding to a Specific Activity of 10,000-100,000 units/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.