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GRO a Human, His
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GRO-Alpha/MGSA Human Recombinant , His Tag
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CHM-242
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Catalogue number
CHM-242
Synonyms
Growth-regulated protein alpha, CXCL1, Melanoma growth stimulatory activity, MGSA, Neutrophil-activating protein 3, NAP-3, GRO-alpha, chemokine ligand 1, GRO1, GROa, SCYB1, MGSA-a, MGSA alpha.
Introduction
趋化因子配体 1 是一种小细胞因子,属于 CXC 趋化因子家族,以前称为 GRO1 致癌基因、中性粒细胞激活蛋白 3 和黑色素瘤生长刺激活性α。 它由人类黑色素瘤细胞分泌,具有促有丝分裂特性,并与黑色素瘤发病机制有关。 CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达,具有中性粒细胞趋化活性。 CXCL1 通过抑制少突胶质细胞前体的迁移在脊髓发育中发挥作用,并参与血管生成、炎症、伤口愈合和肿瘤发生的过程。 这种趋化因子通过趋化因子受体 CXCR2 发出信号来引发其作用。 CXCL1 基因位于人类第 4 号染色体上,位于其他 CXC 趋化因子基因中。
Description
在大肠杆菌中产生的 CXCL1 Human Recombinant 是一条单一的、非糖基化的多肽链,含有 94 个氨基酸,分子量为 10.1 kDa。 CXCL1 在 N 末端与 20 个氨基酸的 His-Tag 融合,并通过专有色谱技术进行纯化。
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
CXCL1 in 20mM Tris-HCL pH-8 and 10% glycerol.
Stability
Liquid CXCL1 although stable at 10°C for 1 week, should be stored below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
Purity
Greater than 90.0% as determined by -PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MASVATELRC QCLQTLQGIH PKNIQSVNVK SPGPHCAQTE VIATLKNGRK ACLNPASPIV KKIIEKMLNS DKSN.
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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