标签： Eotaxin-3 人重组体 CHM-362

C-C motif chemokine 26, Small-inducible cytokine A26, Eotaxin-3, Macrophage inflammatory protein 4-alpha, MIP-4-alpha, Thymic stroma chemokine-1, TSC-1, CC chemokine IMAC, CCL26, SCYA26, IMAC, MIP-4a, MGC126714, MIP-4alpha.

Eotaxin-3 是一种小细胞因子，属于 CC 趋化因子家族，也称为 TARC。 CCL26 是由肺泡上皮细胞产生和释放的主要趋化因子，参与 CCR3 受体和其他趋化因子的自动调节。 Eotaxin-3 参与免疫调节和炎症过程。 Eotaxin-3 特异性结合并刺激 T 细胞中的趋化性，并通过与趋化因子受体 CCR4 相互作用引发其作用。 CCL26 对正常外周血嗜酸性粒细胞和嗜碱性粒细胞表现出趋化活性。 Eotaxin-3 可能在特应性疾病中的嗜酸性粒细胞积累中发挥作用。 Eotaxin-3 在嗜酸性食管炎中过度表达，表达水平与疾病严重程度相关。 Eotaxin-3 在胸腺中组成型表达，但仅在植物血凝素刺激的外周血单核细胞中短暂表达。 CCL26 是聚集在 7 号染色体 q 臂上的两个 Cys-Cys 细胞因子基因之一。

在大肠杆菌中产生的 Eotaxin-3 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 71 个氨基酸，分子量为 8.4kDa。
Eotaxin-3 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.

It is recommended to reconstitute the lyophilized Eotaxin-3 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized Eotaxin-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL26 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by: Analysis by RP-HPLC. Analysis by -PAGE.

TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L.

Determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CCR3. The ED₅₀ for this effect is typically 0.1-1.0 μg/ml.

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