标签： CYT-052

Inhba, Inhibin beta A, FSH releasing protein.

Activins are homodimers or heterodimers of the different ? subunit isoforms, part of the TGF? family. Mature Activin A has two 116 amino acids residues betaA subunits . Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.

激活素是同源二聚体还是异源二聚体？ 亚基异构体，TGF 的一部分？ 家庭。 成熟的激活素 A 有两个 116 个氨基酸残基的 betaA 亚基。 Activin 具有广泛的生物活性，包括中胚层诱导、神经细胞分化、骨重塑、造血和生殖生理学。 激活素参与 FSH、LH、GnRH 和 ACTH 等激素的产生和调节。 经鉴定表达激活素 A 的细胞包括成纤维细胞、内皮细胞、肝细胞、血管平滑肌细胞、巨噬细胞、角质形成细胞、破骨细胞、骨髓单核细胞、前列腺上皮细胞、神经元、软骨细胞、成骨细胞、间质细胞、支持细胞和卵巢颗粒细胞 .

Activin A human Recombinant produced in Nicotiana benthamiana plant is a disulfide-linked homodimers of two betaA chains, each containing 116 amino residues and 6-His-tag at the N-terminal having the total molecular mass of 27.4kDa.

Activin A human Recombinant 生产于本氏烟草植物中，是二硫键连接的两条 betaA 链的同源二聚体，每条链含有 116 个氨基残基和 N 端的 6-His-tag，总分子量为 27.4kDa。

Nicotiana benthamiana plant

Sterile Filtered White lyophilized powder.

Lyophilized from 1mg/ml solution in Tris HCl 0.05M buffer at pH 7.4.

It is recommended to reconstitute the lyophilized Activin A in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized Activin A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Activin A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by Analysis by -PAGE.

HHHHHHGLEC DGKVNICCKK QFFVSFKDIG WNDWIIAPSG YHANYCEGEC PSHIAGTSGS SLSFHSTVIN HYRMRGHSPF ANLKSCCVPT KLRPMSMLYY DDGQNIIKKD IQNMIVEECG CS

The protein was electrophoresed under reducing condition on a 15% -polyacrylamide gel, transferred by electroblotting to a NC membrane and visualized by immune-detection with specific antibody Activin A.

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