lumiprobe -Cyanine3B carboxylic acid,2321-1mg,Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Products
Reactive dyes
Carboxylic acids
Cyanine3B carboxylic acid
Cyanine3B carboxylic acid
Cyanine3, Carboxylic acids, sulfo-Cyanine3,Cy3
Cat. #
Quantity
Price
Lead time
2321-1mg
1 mg
110.00$
8 days
2321-5mg
5 mg
149.00$
8 days
2321-25mg
25 mg
690.00$
8 days
2321-50mg
50 mg
1290.00$
8 days
2321-100mg
100 mg
2450.00$
8 days
General properties
Appearance:
dark red powder
Molecular weight:
560.66
Molecular formula:
C31H32N2O6S
Solubility:
good in DMF, DMSO
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Cyanine3 NHS ester dye for protein labeling, and analog of Cy3® minimal dye.
This reagent is specially quantified – each package contains specified amount of NHS ester with quantity variation within 10%.
用于蛋白质标记的 Cy3 NHS 酯染料和 Cy3® 最小染料的类似物。
该试剂经过特殊量化——每包含有指定量的 NHS 酯，数量变化在 10% 以内。
Cy3 NHS ester minimal dye相关产品
Cyanine5.5 carboxylic acid
Cy5.5 unactivated free acid cyanine dye.
Cy5.5 未活化的游离酸性花青染料。
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Cyanine5 NHS ester minimal dye
Cy5 NHS ester minimal dye for protein labeling.
Cy5 NHS 酯最小染料用于蛋白质标记。
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Sulfo-Cyanine7.5 NHS ester
A water soluble near infrared emitting dye for in vivo imaging applications. Sulfo-Cyanine7.5 is an analog of indocyanine green (ICG) possessing higher emission quantum yield, and containing a linker arm.
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General properties
Appearance:
red solid
Quality control:
NMR 1H, HPLC-MS, functional testing
Storage conditions:
Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Lobov, A.A.; Babkina, I.Y.; Danilov, L.G.; Masharskiy, A.E.; Predeus, A.V.; Mikhailova, N.A.; Granovitch, A.I.; Maltseva, A.L. Species-Specific Proteins in the Oviducts of Snail Sibling Species: Proteotranscriptomic Study of Littorina fabalis and L. obtusata. Biology, 2021, 10(11), 1087. doi: 10.3390/biology10111087
Nixon, B.; Anderson, A.L.; Bromfield, E.G.; Martin, J.H.; Cafe, S.L.; Skerrett-Byrne, D.A.; Dun, M.D.; Eamens, A.L.; De Iuliis, G.N.; Johnston, S.D. Post-testicular sperm maturation in the saltwater crocodile Crocodylus porosus: assessing the temporal acquisition of sperm motility. Reproduction, Fertility, and Development, 2021, 33(9), 530–539. doi: 10.1071/RD20204
Shikov, A.E.; Malovichko, Y.V.; Lobov, A.A.; Belousova, M.E.; Nizhnikov, A.A.; Antonets, K.S. The Distribution of Several Genomic Virulence Determinants Does Not Corroborate the Established Serotyping Classification of Bacillus thuringiensis. International Journal of Molecular Sciences, 2021, 22(5), 2244. doi: 10.3390/ijms22052244
Serteyn, L.; Bosquee, E.; Delatour, A.; Rubio-Melendez, M.E.; Vega-Muñoz, K.V.; Ramirez, C.C.; Francis, F. Multi-approach comparative study of the two most prevalent genotypes of pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae) in Chile. Entomological Science, 2021, 24(1), 55–67. doi: 10.1111/ens.12436
Cy® is a trademark of GE Healthcare.
Purchase of these products does not imply transfer of license to perform methods patented by Carnegie Mellon University and covered by US patents 6,043,025, 6,127,134, 6,246,190, 7566,544, and 7,598,047 “Difference gel electrophoresis using matched multiple dyes” and family members in Australia, Canada, Europe and Japan.
Cyanine3 amine is a functionalized cyanine dye containing a free amino group. Cyanine3 is an analog of Cy3®.
Amino group of this reagent can be conjugated with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides.
The amino dye is supplied in salt form, and possesses some aqueous solubility.
Cy3胺是一种含有游离氨基的功能化花青染料。 Cyanine3 是 Cy3® 的类似物。
该试剂的氨基可与 NHS 酯、羧基（碳二亚胺活化后）和环氧化物等反应基团结合。
氨基染料以盐的形式提供，并具有一定的水溶性。
Cyanine3 absorption and emission spectra
Cyanine3 amine相关产品
Cyanine5.5 azide
Far red / near infrared fluorescent Cyanine5.5 dye derivative for Click Chemistry.
用于 Click Chemistry 的远红/近红外荧光 Cyanine5.5 染料衍生物。
Cyanine7.5 hydrazide
Near infrared fluorophore functionalized with hydrazide moiety. Reactive against carbonyl compounds, useful for the labeling of saccharides, and antibodies after periodate oxidation.
moderate solubility in water, good in polar organic solvents (DMF, DMSO, alcohols)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Wang, Y.; van Steenbergen, M.J.; Beztsinna, N.; Shi, Y.; Lammers, T.; van Nostrum, C.F.; Hennink, W.E. Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery. Journal of Controlled Release, 2020, 328, 970–984. doi: 10.1016/j.jconrel.2020.09.013
Hifni, B.; Khan, M.; Devereux, S.J.; Byrne, M.H.; Quinn, S.J.; Simpson, J.C. Investigation of the cellular destination of fluorescently labelled carbon nanohorns in cultured cells. ACS Applied Bio Materials, 2020, 3(10), 6790–6801. doi: 10.1021/acsabm.0c00748
Teng, F.; Wu, X.; Libera, M.R. Chemical Orthogonality in Surface-Patterned Poly(ethylene glycol) Microgels. Langmuir, 2020, 36(35), 10622–10627. doi: 10.1021/acs.langmuir.0c02172
Zaw Thin, M.; Allan, H.; Bofinger, R.; Kostelec, T.D.; Guillaume, S.; Connell, J.J.; Patrick, P.S.; Hailes, H.C.; Tabor, A.B.; Lythgoe, M.F.; Stuckey, D.J.; Kalber, T.L. Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours. Nanoscale, 2020, 12(31), 16570–16585. doi: 10.1039/d0nr03237a
Free Cyanine3 carboxylic acid (Cy3® carboxylic acid analog), non-activated dye. Non-sulfonated reagent, with good solubility in organic solvents, and limited aquous solubility. The dye can be used as a non-reactive fluorophore, for control experiments, and for calibration.
For coupling with amines, and labeling, consider using Cyanine3 NHS ester, or water-soluble sulfo-Cyanine3 NHS ester.
soluble in organic solvents (DMF, DMSO, dichloromethane), poorly soluble in water (1.8 g/L = 4.0 mM)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Cyanine3 hydrazide is a carbonyl-reactive dye, an analog of Cy3® hydrazide.
This reagent allows to label various carbonyl-containing molecules such as antibodies and other glycoproteins after periodate oxidation, proteins which have undergone oxidative stress or deamination, or reducing saccarides. Cyanine3 is compatible with a number of fluorescent instruments.
Amine reactive NHS ester of near infrared dye Cyanine7.
近红外染料Cy7的胺活性NHS酯。
Cyanine3 azide
Azide derivative of Cyanine3 fluorescent dye for Click Chemistry.
用于 Click Chemistry 的 Cy3 荧光染料的叠氮化物衍生物。
General properties
Appearance:
red powder 红色粉末
Molecular weight:
543.57
Molecular formula:
C30H40Cl2N4O
Solubility:
moderate solubility in water, good in polar organic solvents (DMF, DMSO, alcohols)
Quality control:
NMR 1H and HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Zhao, Meng and Börner, Richard and Sigel, Roland K. O. and Freisinger, Eva. Site-Specific Dual-Color Labeling of Long RNAs. Methods in Molecular Biology, 2020, 2106, 253–270. doi: 10.1007/978-1-0716-0231-7_16
Zhang, J.; Chetnani, B.; Cormack, E.D.; Alonso, D.; Liu, W.; Mondragon, A.; Fei, J. Specific structural elements of the T-box riboswitch drive the two-step binding of the tRNA ligand. eLife, 2018, 7, e39518. doi: 10.7554/eLife.39518
Cui, Z.; Wu, Y.; Mureev, S.; Alexandrov, K. Oligonucleotide-mediated tRNA sequestration enables one-pot sense codon reassignment in vitro. Nucleic Acids Research, 2018, 46(12), 6387–6400. doi: 10.1093/nar/gky365
Porciani, D.; Cardwell, L.N.; Tawiah, K.d.; Alam, K.K.; Lange, M.J.; Daniels, M.A.; Burke, D.H. Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines. Nature Communications, 2018, 9(1), 2283. doi: 10.1038/s41467-018-04691-x
Thiol mono-reactive Cyanine3 dye. This reagent can be used to attach Cyanine3 fluorophore (an analog of Cy3®) to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides).
Cystines should be reduced with TCEP (tris-carboxyethylphosphine) or other appropriate reductant prior to the labeling.
Labeling with Cyanine3 maleimide is selective, and efficient.
We recommend using water-soluble Sulfo-Cyanine3 maleimide for the labeling of antibodies and other sensitive proteins.
well soluble in DMSO (0.50 M = 330 g/L), in DMF, dichloromethane, very poorly soluble in water (0.57 mM = 420 mg/L)
Quality control:
NMR 1H, HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Yang, M.; Zhang, L.; Sun, R.; Zhong, W.; Yang, Y.; Chen, C. Streptococcus pyogenes Cas9 displays biased one-dimensional diffusion on dsDNA to search for a target. bioRxiv, preprint. doi: 10.1101/754564
Mohale, M.; Gundampati, R.K.; Thallapuranam, S.; Heyes, C.D. Site-specific labeling and functional efficiencies of human fibroblast growth Factor-1 with a range of fluorescent dyes in the flexible N-Terminal region and a rigid β-turn region. Analytical Biochemistry, 2022, 640, 114524. doi: 10.1016/j.ab.2021.114524
Cyanine3 alkyne is a fluorophore ready for the use in Click Chemistry reaction.
With this reagent, bright and photostable Cyanine3 reporter, an analog of Cy3®, can be attached to nearly any molecule bearing azide group.
This alkyne is non water-soluble. However, when used with organic co-solvent (DMSO or DMF), this dye can be efficiently attached to water-soluble molecules such as proteins, or peptides.
BDP 558/568 is a borondipyrromethene dye for Cyanine3 channel. This is a terminal alkyne derivative.
BDP 558/568 是一种用于 Cy3 通道的硼二吡咯亚甲基染料。 这是一种末端炔烃衍生物。
Sulfo-Cyanine7 amine
Water-soluble NIR dye amine, sulfonated derivative of Cyanine7 dye, for the modification via enzymatical transamination.
水溶性 NIR 染料胺，Cy7 染料的磺化衍生物，用于通过酶促氨基转移进行修饰。
Cyanine3 carboxylic acid
Free Cyanine3 carboxylic acid.
游离Cyanine3羧酸。
General properties
Appearance:
red powder 红色粉末
Molecular weight:
530.14
Molecular formula:
C33H40ClN3O
Solubility:
soluble in organic solvents (DMF, DMSO, dichloromethane), , practically insoluble in water (50 mg/L = 80 uM)
Quality control:
NMR 1H (95%), HPLC-MS
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Guarin, M.; Faelens, R.; Giusti, A.; De Croze, N.; Léonard, M.; Cabooter, D.; Annaert, P.; de Witte, P.; Ny, A. Spatiotemporal Imaging and Pharmacokinetic of Fluorescent Compounds in Zebrafish Eleuthero-Embryos After Different Routes of Administration. Research Square, preprint. doi: 10.21203/rs.3.rs-237483/v1
Navarro, L.A.; French, D.L.; Zauscher, S. Synthesis of Modular Brush Polymer-Protein Hybrids using Diazotransfer and Copper Click Chemistry. Bioconjugate Chemistry, 2018, 29(8), 2594–2605. doi: 10.1021/acs.bioconjchem.8b00309
Sacoman, J.L.; Dagda, R.Y.; Burnham-Marusich, A.R.; Dagda, R.K.; Berninsone, P.M. Mitochondrial O-GlcNAc transferase (mOGT) regulates mitochondrial structure, function and survival in HeLa cells. Journal of Biological Chemistry, 2017, 292(11), 4499–4518. doi: 10.1074/jbc.M116.726752
Cyanine3 dye azide for Click Chemistry, an analog of Cy3® azide. Cy3® is one of the most broadly used fluorophores which can be detected by various fluorometers, imagers, and microscopes. Due to inherently high extinction coefficient, Cyanine3 is also easily detected by naked eye on gels, and in solution. This is non-sulfonated dye which requires organic co-solvent (DMF, DMSO, or other) for efficient labeling in water. Water-soluble version of this reagent is also available.
Product is available both as solid compound, and as 10 mM solution in DMSO which is ready to use in our recommended protocol.
Cyanine3 fluorescent properties are identical to Cy3®, and similar to DyLight 549.
BDP 581/591 is a borondipyrromethene fluorophore which is useful for fluorescence polarization assays, microscopy, and two photon experiments. This alkyne is a derivative for copper-catalyzed Click chemistry.
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General properties
Appearance:
red powder / solution 红粉/溶液
Molecular weight:
575.19
CAS number:
1167421-28-4 (chloride)
Molecular formula:
C33H43N6OCl
Solubility:
soluble in organic solvents (DMF, DMSO, dichloromethane), practically insoluble in water (40 mg/L = 60 uM)
Quality control:
NMR 1H and HPLC-MS (95%)
Storage conditions:
Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
Kim, S.M.; Park, J.; Kim, M.S.; Song, H.; Jo, A.; Park, H.; Kim, T.S.; Choi, S.H.; Park, S.B. Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR. ACS Infectious Diseases, 2020, 6(11), 3076–3082. doi: 10.1021/acsinfecdis.0c00587
Saqr, A.; Vakili, M.R.; Huang, Y.-H.; Lai, R.; Lavasanifar, A. Development of Traceable Rituximab-Modified PEO-Polyester Micelles by Postinsertion of PEG-phospholipids for Targeting of B-cell Lymphoma. ACS Omega, 2019, 4(20), 18867–18879. doi: 10.1021/acsomega.9b02910
Morimoto, K.; Cole, K.S.; Kourelis, J.; Witt, C.H.; Brown, D.; Krahn, D.; Stegmann, M.; Kaschani, F.; Kaiser, M.; Burton, J.; Mohammed, S.; Yamaguchi-Shinozaki, K.; Weerapana, E.; van der Hoorn, R.A.L. Triazine Probes Target Ascorbate Peroxidases in Plants. Plant Physiology, 2019, 180(4), 1848–1859. doi: 10.1104/pp.19.00481
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