标签： CXCL4 Variant 1 Human

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets . Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。 它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血。 作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化素家族的成员。 人 PF4 用于证明诱导的血小板减少症。 此外，它还用作肿瘤治疗期间血管生成的抑制剂。

CXCL4 Variant-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa.
The CXCL4 Variant-1 is fused to 6xHis tag at N-Terminus and purified by standard chromatography techniques.

Escherichia Coli.

Sterile Filtered white lyophilized powder.

The protein was lyophilized without additives.

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by -PAGE.

MHHHHHHEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES.

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