标签： Cross linking reagents

Azide-PEG4-Azide

Azide-PEG4-Azide,PEG4 二叠氮化物是具有两个叠氮基的亲水接头。 两者都可以通过点击化学进行修饰，或者通过铜催化与末端炔烃的反应，或通过与环炔烃的无铜反应。 叠氮化物也可以参与施陶丁格连接反应。

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Azide-PEG4-Azide

标签：Azides,Click chemistry,Cross linking reagents,PEG4 (tetraethylene glycol)
货号 规格 价格 货期
1865-1g 1 g 90.00$ in stock
1865-5g 5 g 250.00$ in stock
1865-25g 25 g 950.00$ in stock
PEG4 diazide is a hydrophilic linker with two azide groups. Both can be modified by Click chemistry, either by a copper catalyzed reaction with terminal alkynes, or by a copper-free reaction with cycloalkynes. Azides can also participate in the Staudinger ligation reaction.

This diazide is useful for the synthesis of dimeric molecules by Click chemistry.

PEG4 二叠氮化物是具有两个叠氮基的亲水接头。 两者都可以通过点击化学进行修饰，或者通过铜催化与末端炔烃的反应，或通过与环炔烃的无铜反应。 叠氮化物也可以参与施陶丁格连接反应。

这种二叠氮化物可用于通过点击化学合成二聚体分子。

Azide-PEG4-Azide Azide-PEG4-Azide Azide-PEG4-Azide Azide-PEG4-Azide

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Azide-PEG3-Azide

Triethylene glycol diazide (CAS# 59559-06-7) is a bifunctional crosslinker bearing two azide groups. Suitable for Click chemistry.

三甘醇二叠氮化物 (CAS# 59559-06-7) 是一种带有两个叠氮基的双功能交联剂。 适用于点击化学。

Cyanine7 NHS ester

Amine reactive NHS ester of near infrared dye Cyanine7.

近红外染料Cy7的胺活性NHS酯。

Cyanine5 NHS ester

Amine-reactive Cyanine5 activated ester for the labeling of proteins, peptides, and other molecules.

胺反应性 Cy5 活化酯，用于标记蛋白质、肽和其他分子。

General properties

Appearance: colorless liquid
Molecular weight: 244.25
CAS number: 101187-39-7
Molecular formula: C8H16N6O3
Solubility: miscible with water, polar organic solvents
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

储存：-20°C 收货后 24 个月。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。
MSDS: Download
Product specifications

Azide-PEG4-Amine

Azide-PEG4-Amine,低聚乙二醇是通用的亲水性接头。 每个单体的长度为 3.43 Å，因此 PEG4 的长度约为 14 Å (1.4 nm)。

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Azide-PEG4-Amine

标签：Azides,Amines,Click chemistry,Cross linking reagents,PEG4 (tetraethylene glycol)
货号 规格 价格 货期
1868-1g 1 g 90.00$ in stock
1868-5g 5 g 250.00$ in stock
1868-25g 25 g 950.00$ in stock
Oligoethylene glycols are versatile hydrophilic linkers. Each monomer has a length of 3.43 Å, so that the length of PEG4 is around 14 Å (1.4 nm).

Azide-PEG4-Amine is a bifunctional compound with an amine group that can be modified by acylation by activated esters or similar carbonyl compounds, and an azide group that is suitable for Click chemistry reactions. PEG4 is highly hydrophilic and biocompatible.

低聚乙二醇是通用的亲水性接头。 每个单体的长度为 3.43 Å，因此 PEG4 的长度约为 14 Å (1.4 nm)。

叠氮化物-PEG4-Amine 是一种双官能化合物，具有可通过活化酯或类似羰基化合物酰化修饰的胺基，以及适用于 Click 化学反应的叠氮基。 PEG4 具有高度亲水性和生物相容性。

Azide-PEG4-Amine Azide-PEG4-Amine Azide-PEG4-Amine Azide-PEG4-Amine

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Ascorbic acid

Ascorbic acid for the reduction of Cu(II)-TBTA complex.

抗坏血酸用于还原 Cu(II)-TBTA 配合物。

Alkyne-PEG4-Amine

A bifunctional linker molecule containing both terminal alkyne moiety for Click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.

一种双功能连接分子，包含用于点击化学的末端炔烃部分和胺基。 包含一个长的亲水性 PEG4 臂。

DBCO NHS ester

Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain promoted copper free Click chemistry (spAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.

用于应变促进无铜点击化学 (spAAC) 的偶氮二苯并环辛炔 (DBCO, ADIBO) 试剂。 该试剂含有 NHS 酯功能，用于将环辛炔连接到各种分子上。

General properties

Appearance: colorless to yellowish liquid
Molecular weight: 218.25
CAS number: 134179-38-7
Molecular formula: C8H18N4O3
Solubility: miscible with water, polar organic solvents
Quality control: NMR 1H,GC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.

储存：-20°C 收货后 24 个月。 运输：在室温下长达 3 周。 干燥。
MSDS: Download
Product specifications

Azide-PEG3-Azide

Azide-PEG3-Azide,PEG3（三甘醇）二叠氮化物（1,8-diazido-3,6-dioxaoctane）是一种对称的双功能交联剂，带有两个叠氮基。

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Azide-PEG3-Azide

标签：Azides,Click chemistry,PEG3 (triethylene glycol),Cross linking reagents
货号 规格 价格 货期
207-1g 1 g 95.00$ in stock
207-5g 5 g 390.00$ in stock
207-25g 25 g please inquire in stock
PEG3 (triethylene glycol) diazide (1,8-diazido-3,6-dioxaoctane) is a symmetrical bifunctional crosslinker bearing two azide groups.
PEG3（三甘醇）二叠氮化物（1,8-diazido-3,6-dioxaoctane）是一种对称的双功能交联剂，带有两个叠氮基。

Azide-PEG3-Azide Azide-PEG3-Azide Azide-PEG3-Azide > Azide-PEG3-Azide

Azide-PEG3-Azide相关产品

Alkyne hydrazide

Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.

含有炔基和酰肼官能团的双功能试剂。 它与醛和酮反应。 然后炔基可以通过CuAAC反应与各种叠氮化物偶联。

Azide-PEG3-Amine

A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)

PEG3-Dicarboxylic acid

PEG3-Ddicarboxylic acid is a bifunctional linker carrying two carboxy groups. It contains a polyethyleneglycol-3 linker between the carboxyls.

PEG3-D二羧酸是一种带有两个羧基的双功能接头。 它在羧基之间包含一个聚乙二醇-3 接头。

General properties

Appearance: colorless/yellowish liquid
Molecular weight: 200.2
CAS number: 59559-06-7
Molecular formula: C6H12N6O2
IUPAC name: 1,8-diazido-3,6-dioxaoctane, 1,2-bis(2-azidoethoxy)ethane
Solubility: good in water and most organic solvents
Quality control: NMR 1H, GC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.

储存：-20°C 收货后 24 个月。 运输：在室温下长达 3 周。 干燥。
MSDS: Download
Product specifications

相关文献：

  1. Hull, S.M.; Lindsay, C.D.; Brunel, L.G.; Shiwarski, D.J.; Tashman, J.W.; Roth, J.G.; Myung, D.; Feinberg, A.W.; Heilshorn, S.C. 3D Bioprinting using UNIversal Orthogonal Network (UNION) Bioinks. Advanced Functional Materials, 2021, 31(7), 2007983. doi: 10.1002/adfm.202007983
  2. Tolentino, M.Q.; Hartmann, A.K.; Loe, D.T.; Rouge, J.L. Controlled release of small molecules and proteins from DNA-surfactant stabilized metal organic frameworks. Journal of Materials Chemistry B, 2020, 8(26), 5627–5635. doi: 10.1039/d0tb00767f

Azide-PEG3-Amine

Azide-PEG3-Amine,叠氮化物-PEG3-胺是一种双功能试剂，具有叠氮基团和位于三甘醇两侧的胺基团。 该接头可用于羧基衍生物（通过胺基的酰化）与炔烃（通过点击化学反应）的缀合。

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Azide-PEG3-Amine

标签：Azides,Amines,Click chemistry,PEG3 (triethylene glycol),Cross linking reagents
货号 规格 价格 货期
218-1g 1 g 95.00$ in stock
218-5g 5 g 280.00$ in stock
218-25g 25 g please inquire in stock
Azide-PEG3-amine is a bifunctional reagent with an azide group, and an amine group flanking triethylene glycol. This linker is useful for the conjugation of carboxylic derivatives (by acylation of the amine group) with alkynes (via a Click chemistry reaction).
叠氮化物-PEG3-胺是一种双功能试剂，具有叠氮基团和位于三甘醇两侧的胺基团。 该接头可用于羧基衍生物（通过胺基的酰化）与炔烃（通过点击化学反应）的缀合。

Azide-PEG3-Amine Azide-PEG3-Amine Azide-PEG3-Amine Azide-PEG3-Amine

Azide-PEG3-Amine相关产品

Cyanine3.5 NHS ester

Cyanine3.5 dye NHS ester derivative.

Cy3.5染料NHS酯衍生物。

PEG3-Dicarboxylic acid

PEG3-Ddicarboxylic acid is a bifunctional linker carrying two carboxy groups. It contains a polyethyleneglycol-3 linker between the carboxyls.

PEG3-D二羧酸是一种带有两个羧基的双功能接头。 它在羧基之间包含一个聚乙二醇-3 接头。

Sulfo-Cyanine7 NHS ester

Sulfo-Cyanine7 NHS ester is a water soluble, near infrared, amine-reactive dye.

Sulfo-Cy7 NHS 酯是一种水溶性、近红外、胺反应性染料。

General properties

Appearance: colorless/yellowish oil
Molecular weight: 174.2
CAS number: 166388-57-4
Molecular formula: C6H14N4O2
IUPAC name: 1-Amino-8-azido-3,6-dioxaoctane
Solubility: good in water and most organic solvents
Quality control: NMR 1H, GCMS (95%)
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.

储存：-20°C 收货后 24 个月。 运输：在室温下长达 3 周。 干燥。
MSDS: Download
Product specifications

DBCO NHS ester

DBCO NHS ester,二苯并环辛炔 (ADIBO, DBCO) 是对应变促进炔烃叠氮化物环加成 (spAAC) 反应性最强的环炔烃之一 – 一种无铜点击化学反应。

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DBCO NHS ester

标签：NHS esters, Alkynes, Copper free Click chemistry, Cycloalkyne, Protein labeling, Cross linking reagents
货号 规格 价格 货期
34720 10 mg 60.00$ in stock
44720 25 mg 95.00$ in stock
54720 50 mg 145.00$ in stock
64720 100 mg 210.00$ in stock
94720 1 g 1190.00$ in stock
K4720 5 g 3570.00$ in stock
N4720 25 g please inquire 21 days

Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cycloalkynes for strain promoted alkyne azide cycloaddition (spAAC) – a copper free Click chemistry reaction.

This is an amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.

DBCO reacts instantly with azides. The rate of the reaction is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines – this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.

二苯并环辛炔 (ADIBO, DBCO) 是对应变促进炔烃叠氮化物环加成 (spAAC) 反应性最强的环炔烃之一 – 一种无铜点击化学反应。

这是一种胺反应性 NHS 酯，可将反应性部分轻松连接到几乎任何伯胺或仲胺基团，例如蛋白质、肽或小分子胺的基团。

DBCO 立即与叠氮化物发生反应。 该反应的速率远高于铜催化的反应，以及与许多其他环辛炔的反应。 与其他一些环辛炔不同，DBCO 不与四嗪反应 – 这允许叠氮化物与 DBCO 以及反式环辛烯与四嗪的正交共轭。

DBCO NHS ester相关产品

FAM azide, 6-isomer

FAM (fluorescein) azide, 6-isomer is a commonly used fluorescent dye azide for Click Chemistry.

FAM（荧光素）叠氮化物，6 异构体是 Click Chemistry 中常用的荧光染料叠氮化物。

Sulfo-Cyanine5.5 carboxylic acid

Water soluble far red fluorescent dye sulfo-Cyanine5.5, free non-activated carboxylic acid. Useful for the calibration, and as a non-reactive control.

水溶性远红荧光染料sulfo-Cy5.5，游离非活化羧酸。 用于校准，并作为非反应控制。

Cyanine3.5 NHS ester

Cyanine3.5 dye NHS ester derivative.

Cy3.5染料NHS酯衍生物。

General properties

Appearance: off white solid
Mass spec M+ increment: 315.1
Molecular weight: 430.45
CAS number: 1384870-47-6
Molecular formula: C25H22N2O5
IUPAC name: 6-{2-Azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-6-oxohexanamide
Solubility: good in DCM, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

储存：收到后 12 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。
MSDS: Download
Product specifications

相关文献：

  1. Adams, M.R.; Moody, C.T.; Sollinger, J.L.; Brudno, Y. Extracellular Matrix-Anchored Click Motifs for Specific Tissue Targeting. Molecular Pharmaceutics, 2020, 17(2), 392–403. doi: 10.1021/acs.molpharmaceut.9b00589
  2. Alshanski, I.; Blaszkiewicz, J.; Mervinetsky, E.; Rademann, J.; Yitzchaik, S.; Hurevich, M. Sulfation Patterns of Saccharides and Heavy Metal Ions Binding. Chemistry, 2019, 25(52), 12083–12090. doi: 10.1002/chem.201901538
  3. Andersen, V.L.; Vinther, M.; Kumar, R.; Ries, A.; Wengel, J.; Nielsen, J.S.; Kjems, J. A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine. Theranostics, 2019, 9(9), 2662–2677. doi: 10.7150/thno.32060

Alkyne NHS ester (hexynoic acid NHS ester)

Alkyne NHS ester (hexynoic acid NHS ester),用于生物分子修饰的炔烃 NHS 酯。 用于铜催化点击化学反应的炔基在天然分子中几乎从未遇到过。 然而，这种 NHS 酯允许将炔基连接到氨基上，氨基在自然界中普遍存在，并且存在于蛋白质、肽、合成氨基 DNA 和许多小分子中。 随后可以通过铜催化的点击化学修饰和缀合炔基。

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Alkyne NHS ester (hexynoic acid NHS ester)

标签：NHS esters, Alkynes, Protein labeling, Cross linking reagents
货号 规格 价格 货期
41720 25 mg 95.00$ in stock
51720 50 mg 195.00$ in stock
61720 100 mg 290.00$ in stock
91720 1 g please inquire in stock

Alkyne NHS ester for the modification of biomolecules. Alkyne groups for copper catalyzed Click Chemistry reaction are nearly never encountered in natural molecules. However, this NHS ester allows to attach alkyne groups to amino groups, which are ubiquitous in nature, and which are present in proteins, peptides, synthetic amino-DNA and numerous small molecules. Alkyne groups can be subsequently modified and conjugated by Copper catalyzed Click chemistry.

This reagent is a derivative of hexynoic acid.

用于生物分子修饰的炔烃 NHS 酯。 用于铜催化点击化学反应的炔基在天然分子中几乎从未遇到过。 然而，这种 NHS 酯允许将炔基连接到氨基上，氨基在自然界中普遍存在，并且存在于蛋白质、肽、合成氨基 DNA 和许多小分子中。 随后可以通过铜催化的点击化学修饰和缀合炔基。

该试剂是己炔酸的衍生物。

Alkyne NHS ester (hexynoic acid NHS ester)相关产品

EdU (5-ethynyl-2′-deoxyuridine)

EdU is a nucleoside which is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by Click chemistry reaction with fluorescent dye azides to reveal cell proliferation.

EdU 是一种核苷，可通过细胞酶掺入复制的 DNA 中。 之后，细胞中所含的 DNA 可以通过与荧光染料叠氮化物的 Click 化学反应进行显色，以揭示细胞增殖情况。

AF488 NHS ester

AF488 NHS ester, a bright, photostable and hydrophilic fluorescent dye for green channel.

AF488 NHS 酯，一种用于绿色通道的明亮、光稳定性和亲水性荧光染料。

Pyrenebutyric acid NHS ester

Pyrene NHS ester for the labeling of biomolecules with pyrene residue. Pyrene is a fluorescent proximity probe which forms excimers, and it is also an anchor group for graphite immobilization.

芘 NHS 酯，用于用芘残基标记生物分子。 芘是一种形成准分子的荧光邻近探针，也是石墨固定的锚定基团。

General properties

Appearance: yellowish oil / off white crystals 淡黄色油状物/类白色结晶
Mass spec M+ increment: 94.0
Molecular weight: 209.20
CAS number: 906564-59-8
Molecular formula: C10H11NO4
IUPAC name: 5-​Hexynoic acid, 2,​5-​dioxo-​1-​pyrrolidinyl ester
Solubility: good in organic solvents (DMF, DMSO, DCM)
Quality control: NMR 1H 95+%
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

储存：收到后 12 个月，在 -20°C 避光保存。 运输：在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。
MSDS: Download
Product specifications

相关文献：

  1. Zanon, P.R.A.; Yu, F.; Musacchio, P.; Lewald, L.; Zollo, M.; Krauskopf, K.; Mrdović, D.; Raunft, P.; Maher, T.E.; Cigler, M.; Chang, C.; Lang, K.; Toste, F.D.; Nesvizhskii, A.I.; Hacker, S.M. Profiling the proteome-wide selectivity of diverse electrophiles. ChemRxiv, preprint. doi: 10.33774/chemrxiv-2021-w7rss-v2
  2. Kleinpenning, F.; Steigenberger, B.; Wu, W.; Heck, A.J.R. Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications, 2020, 11, 3244. doi: 10.1038/s41467-020-17010-0

Azidobutyric acid NHS ester

Azidobutyric acid NHS ester,使用该试剂将您的蛋白质和肽转化为 Click Chemistry 反应形式。

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  • Azidobutyric acid NHS ester

Azidobutyric acid NHS ester

标签：NHS esters, Protein labeling, Cross linking reagents
货号 规格 价格 货期
53720 50 mg 60.00$ in stock
63720 100 mg 95.00$ in stock
73720 1 g please inquire in stock
83720 5 g please inquire in stock

Convert your proteins and peptides into Click Chemistry reactive form with this reagent.

While Click Chemistry involves reaction between terminal alkyne and azide, both azides and alkynes are very uncommon in nature. However, there are reagents to attach these fragments to abundant amino groups which are ubiquitous in the world of biomolecules. This azido-NHS ester is designed for the conversion of proteins, peptides, amino-DNA, and other amines into Click Chemistry reactive azides.

使用该试剂将您的蛋白质和肽转化为 Click Chemistry 反应形式。

虽然 Click Chemistry 涉及末端炔烃和叠氮化物之间的反应，但叠氮化物和炔烃在自然界中都非常罕见。 然而，有一些试剂可以将这些片段连接到丰富的氨基上，这些氨基在生物分子的世界中无处不在。 这种叠氮基-NHS 酯设计用于将蛋白质、肽、氨基-DNA 和其他胺转化为 Click Chemistry 反应性叠氮化物。

Azidobutyric acid NHS ester相关产品

Cyanine7 carboxylic acid

Non-reactive, near-infrared fluorescent dye.

非反应性近红外荧光染料。

TAMRA azide, 5-isomer

TAMRA fluorescent dye azide for Click chemistry.

用于点击化学的 TAMRA 荧光染料叠氮化物。

Cyanine5 azide

Cyanine5 azide is a reagent for Click Chemistry labeling with Cyanine5, a popular fluorescent dye.

Cy5 azide 是一种用 Cy5（一种流行的荧光染料）进行 Click Chemistry 标记的试剂。

General properties

Appearance: colorless solid 无色固体
Mass spec M+ increment: 111.0
Molecular weight: 226.19
CAS number: 943858-70-6
Molecular formula: C8H10N4O4
IUPAC name: Butanoic acid, 4-​azido-​, 2,​5-​dioxo-​1-​pyrrolidinyl ester
Solubility: soluble in organic solvents (DMF, DMSO)
Quality control: NMR 1H (95%), HPLC
Storage conditions: Storage: 12 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.

储存：-20°C 收货后 12 个月。 运输：在室温下长达 3 周。 干燥。
MSDS: Download
Product specifications

相关文献：

  1. Wang, Y.; Yao, J.; Cai, L.; Liu, T.; Wang, X.; Zhang, Y.; Zhou, Z.; Li, T.; Liu, M.; Lai, R.; Liu, X. Bone-targeted extracellular vesicles from mesenchymal stem cells for osteoporosis therapy. Research Square, preprint. doi: 10.21203/rs.3.rs-18279/v1
  2. Kleinpenning, F.; Steigenberger, B.; Wu, W.; Heck, A.J.R. Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications, 2020, 11, 3244. doi: 10.1038/s41467-020-17010-0
  3. Blanchard, A.T.; Bazrafshan, A.S.; Yi, J.; Eisman, J.T.; Yehl, K.M.; Bian, T.; Mugler, A.; Salaita, K. Highly Polyvalent DNA Motors Generate 100+ pN of Force via Autochemophoresis. Nano Letters, 2019, 19(10), 6977–6986. doi: 10.1021/acs.nanolett.9b02311
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