sumo修饰是一种可逆的翻译后修饰，已成为一种重要的分子调控机制，参与DNA损伤修复、免疫应答、致癌、细胞周期进程和凋亡的调控。已鉴定出四种SUMO异构体，分别为SUMO1、SUMO2/3和SUMO4。小泛素样修饰物(SUMO)通路在所有真核生物中都是保守的，在基因表达、细胞信号传导和Cosmo Bio抗体, (Clone 3H12),CAC-CEC-044基因组完整性的维持中起着关键作用。SUMO催化循环包括成熟、活化、偶联、连接和去修饰。SUMO系统的失调与许多疾病有关，特别是癌症。sumo酰化在致癌、DNA损伤反应、癌细胞增殖、转移和凋亡等过程中具有广泛的作用。SUMO可作为一种潜在的癌症治疗靶点。
Anti Small Ubiquitin-Related Modifier 2 (SUMO2) and Small Ubiquitin-Related Modifier 3 (SUMO3) mAb (Clone 3H12),CAC-CEC-044
Application: ICC, IHC, WB, IF
Clonality: Monoclonal
Host: Rat
Purification: IgG, Ion-exchange Chromatography, Gel Filtration
Reactivity: Monkey, Mouse, Rat, Human
SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryotes and plays pivotal roles in the regulation of gene expression, cellular signaling and the maintenance of genomic integrity. The SUMO catalytic cycle includes maturation, activation, conjugation, ligation and de-modification. The dysregulation of the SUMO system is associated with a number of diseases, particularly cancer. SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis. SUMO can be used as a potential therapeutic target for cancer.