标签： CHM-246

Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11.

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B . CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。 它存在于牙齿萌出和骨骼退化的部位。 在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 βB 的控制。 CCL2 将免疫细胞（例如单核细胞）募集到组织损伤和感染部位。 这种趋化因子作为蛋白质前体产生，含有 23 个氨基酸的信号肽和 76 个氨基酸的成熟肽。 它是一种单体多肽，分子量约为 13kDa。 与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。 结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP-1 Human Recombinant also known as Monocyte Chemotactic and Activating Factor produced in E.Coli is a non-glycosylated, Polypeptide chain containing 97 amino acids and having a molecular mass of 10.9 kDa.
The MCP-1 is fused to 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered colorless clear solution.

The His Tag MCP-1 protein solution contains 20mM Tris-HCL pH-8.0, 1mM DTT and 20% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Greater than 95.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MQPDAINAPV TCCYNFTNRK ISVQRLASYR RITSSKCPKE AVIFKTIVAK EICADPKQKW VQDSMDHLDK QTQTPKT.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.