标签： CHM-232

Small inducible cytokine B11, CXCL11, Interferon-inducible T-cell alpha chemoattractant, I-TAC, Interferon-gamma-inducible protein 9, IP-9, H174, Beta-R1, chemokine ligand 11, IP9, b-R1, SCYB11, SCYB9B, MGC102770.

Chemokine ligand 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant and Interferon-gamma-inducible protein 9 . It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

趋化因子配体 11 是一种小细胞因子，属于 CXC 趋化因子家族，也称为干扰素诱导型 T 细胞 α 趋化因子和干扰素-γ 诱导蛋白 9。 它在外周血白细胞、胰腺和肝脏中高表达，在胸腺、脾脏和肺中表达中等，在小肠、胎盘和前列腺中低表达。 CXCL11的基因表达受IFN-g和IFN-b强烈诱导，而受IFN-a弱诱导。 这种趋化因子通过与细胞表面趋化因子受体 CXCR3 相互作用而对其靶细胞产生影响，其亲和力高于该受体的其他配体 CXCL9 和 CXCL10。 CXCL11 对活化的 T 细胞具有趋化性。 它的基因与 CXC 趋化因子家族的许多其他成员一起位于人类第 4 号染色体上。

I-TAC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 94 amino acids and having a molecular mass of 10.6kDa.
I-TAC is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 I-TAC Human Recombinant 是单一的非糖基化多肽链，含有 94 个氨基酸，分子量为 10.6kDa。
I-TAC 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile filtered colorless solution.

The I-TAC solution contains 10mM sodium citrate, 20% glycerol and 2mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.