标签： CHM-014

Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11.

Chemokine ligand 2 is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 . It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B . CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.

趋化因子配体 2 是属于 CC 趋化因子家族的小细胞因子，也称为单核细胞趋化蛋白 1。 它存在于牙齿萌出和骨骼退化的部位。 在骨骼中，CCL2 由成熟的破骨细胞和成骨细胞表达，并受核因子 βB 的控制。 CCL2 将免疫细胞（例如单核细胞）募集到组织损伤和感染部位。 这种趋化因子作为蛋白质前体产生，含有 23 个氨基酸的信号肽和 76 个氨基酸的成熟肽。 它是一种单体多肽，分子量约为 13kDa。 与许多其他 CC 趋化因子一样，CCL2 位于人类的第 17 号染色体上。 结合 CCL2 的细胞表面受体是 CCR2 和 CCR5。

MCP-1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 146 amino acids and having a molecular mass of 16kDa.
MCP-1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 MCP-1 Mouse Recombinant 是一条单一的、非糖基化的多肽链，含有 146 个氨基酸，分子量为 16kDa。
MCP-1 在 N 末端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered colorless clear solution.

MCP-1 protein solution containing PBS and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

Greater than 90.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MQPDAVNAPL TCCYSFTSKM IPMSRLESYK RITSSRCPKE AVVFVTKLKR EVCADPKKEW VQTYIKNLDR NQMRSEPTTL FKTASALRSS APLNVKLTRK SEANASTTFS TTTSSTSVGV TSVTVN.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.