标签： CD74人重组PRO-2225

DHLAG, HLADG, Ia-GAMMA, li, HLA-DR antigens-associated invariant chain, p33, Ia antigen-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, Gamma Chain Of Class II Antigens, MHC HLA-DR Gamma Chain.

CD74 , is a transmembrane protein which is the invariant chain that chaperones MHC class IIdimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and Blymphocyte lineages. CD74 upregulated in several cancers and is also expressed by non immune cells during inflammation. Diseases related with CD74 include thymic epithelial neoplasm and gastroduodenitis. Among its related super-pathways are Immune System and Immune response Antigen presentation by MHC class II. In addition CD74 functions as cell surface receptor for the cytokine MIF.

CD74 是一种跨膜蛋白，它是陪伴 MHC II 类二聚体从内质网到细胞表面的不变链。 CD74 由 T 淋巴细胞和 B 淋巴细胞谱系的细胞表达。 CD74 在几种癌症中上调，并且在炎症期间也由非免疫细胞表达。 与 CD74 相关的疾病包括胸腺上皮肿瘤和胃十二指肠炎。 其相关的超级途径包括 MHC II 类的免疫系统和免疫反应抗原呈递。 此外，CD74 作为细胞因子 MIF 的细胞表面受体发挥作用。

CD74 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 19.05kDa . CD74 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD74 是单条糖基化多肽链，包含 166 个氨基酸，分子量为 19.05kDa。 CD74 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile filtered colorless solution.

CD74 protein solution contains phosphate buffered saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85.0% as determined by -PAGE.

QQQGRLDKLT VTSQNLQLEN LRMKLPKPPK PVSKMRMATP LLMQALPMGA LPQGPMQNAT KYGNMTEDHV MHLLQNADPL KVYPPLKGSF PENLRHLKNT METIDWKVFE SWMHHWLLFE MSRHSLEQKP TDAPPKESLE LEDPSSGLGV TKQDLGPVPM HHHHHH.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.