标签： CD33 Human

CD33Molecule, CD33Antigen , Sialic Acid Binding Ig-Like Lectin 3, Sialic Acid-Binding Ig-Like Lectin 3, SIGLEC3, gp67, SIGLEC-3, Myeloid Cell Surface AntigenCD33, p67, Siglec-3, CD33Antigen.

CD33 is putative adhesion molecule of myelomonocytic-derived cells which mediates sialic-acid dependent binding to cells. CD33 prefers to bind to alpha-2,6-linked sialic acid. The sialic acid recognition site is masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 perform as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases through their SH2 domains which block signal transduction through dephosphorylation of signaling molecules. In addition, CD33 induces apoptosis in acute myeloid leukemia.

CD33 是骨髓单核细胞衍生细胞的推定粘附分子，它介导唾液酸依赖性与细胞的结合。 CD33 更喜欢与 α-2,6 连接的唾液酸结合。 唾液酸识别位点被同一细胞表面上与唾液酸的顺式相互作用所掩盖。 在免疫反应中，CD33 作为配体诱导的酪氨酸磷酸化的抑制性受体，通过其 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断信号转导。 此外，CD33 在急性髓性白血病中诱导细胞凋亡。

CD33 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids and having a molecular mass of 29.1kDa.

Escherichia Coli.

Sterile Filtered clear solution.

CD33 protein solution containing 20mM Tris-HCl buffer , 0.4M Urea, and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.

Greater than 90% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSDPNFWLQ VQESVTVQEG LCVLVPCTFF HPIPYYDKNS PVHGYWFREG AIISGDSPVA TNKLDQEVQE ETQGRFRLLG DPSRNNCSLS IVDARRRDNG SYFFRMERGS TKYSYKSPQL SVHVTDLTHR PKILIPGTLE PGHSKNLTCS VSWACEQGTP PIFSWLSAAP TSLGPRTTHS SVLIITPRPQ DHGTNLTCQV KFAGAGVTTE RTIQLNVTYV PQNPTTGIFP GDGSGKQETR AGVVH.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.