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CD27 Human
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CD27 Human Recombinant
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PRO-1213
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Catalogue number
PRO-1213
Synonyms
Tumor Necrosis Factor Receptor Superfamily Member 7,T-Cell Activation Antigen CD27, CD27 Molecule, CD27 Antigen,T Cell Activation Antigen S152, CD27L Receptor, TNFRSF7, S152, Tp55, T14.
Introduction
CD27 belongs to the TNF-receptor superfamily. CD27 is necessary for initiation and long-term maintenance of T cell immunity. CD27 binds to ligand CD70, and has a crucial role in regulating B-cell activation and immunoglobulin synthesis. The CD27 receptor transduces signals which result in the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 mediate the signaling process of CD27. CD27-binding protein , which is a proapoptotic protein, can bind to the CD27 receptor and is believed to have a significant role in the apoptosis induced by CD27.
CD27 属于 TNF 受体超家族。 CD27 是启动和长期维持 T 细胞免疫所必需的。 CD27 与配体 CD70 结合，在调节 B 细胞活化和免疫球蛋白合成中起关键作用。 CD27 受体转导导致 NF-kappaB 和 MAPK8/JNK 激活的信号。 衔接蛋白 TRAF2 和 TRAF5 介导 CD27 的信号传导过程。 CD27结合蛋白是一种促凋亡蛋白，可与CD27受体结合，被认为在CD27诱导的细胞凋亡中具有重要作用。
Description
CD27 Human Recombinant produced in E. coli is a single polypeptide chain containing 196 amino acids and having a molecular mass of 21.8 kDa.
CD27 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CD27 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 CD27 Human Recombinant 是单条多肽链，包含 196 个氨基酸，分子量为 21.8 kDa。
CD27 在 N 端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。
CD27 在 N 端与 25 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。
Source
E.coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The CD27 solution contains 20mM Tris-HCl buffer , 0.4M Urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90% as determined by -PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSHMTPAPK SCPERHYWAQ GKLCCQMCEP GTFLVKDCDQ HRKAAQCDPC IPGVSFSPDH HTRPHCESCR HCNSGLLVRN CTITANAECA CRNGWQCRDK ECTECDPLPN PSLTARSSQA LSPHPQPTHL PYVSEMLEAR TAGHMQTLAD FRQLPARTLS THWPPQRSLC SSDFIR.
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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