标签： CD207 人类重组体sf9 PRO-2317

ProSpec-CD207 Human sf9,CD207 人类重组体sf9 PRO-2317

ProSpec-CD207 Human sf9,CD207 人类重组体sf9 PRO-2317,CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中

  • CD207 Human, sf9

  • CD207 Human Recombinant, sf9
  • PRO-2317

Catalogue number

PRO-2317

Synonyms

C-type lectin domain family 4 member K, Langerin, CD207, CD207 Molecule, CD207 Molecule, Langerin, CD207 Antigen, Langerin, CLEC4K, Langerhans Cell Specific C-Type Lectin, Langerin.

Introduction

CD207 is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Moreover, CD207 is expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, the organelles present in the cytoplasm of Langerhans cells and comprised of superimposed and zippered membranes. CD207 is a C-type lectin with mannose binding specificity, and it has been suggested that mannose binding by the CD207 protein leads to internalization of antigen into Birbeck granules thus providing access to a nonclassical antigen-processing pathway.
CD207 在朗格汉斯细胞中表达，朗格汉斯细胞是表皮和粘膜的未成熟树突细胞。 此外，CD207 在其他几种树突细胞类型中表达，包括真皮 CD103+ DCs 和脾 CD8+ DCs。 Langerin 位于伯贝克颗粒中，该细胞器存在于朗格汉斯细胞的细胞质中，由重叠的拉链膜组成。 CD207 是一种具有甘露糖结合特异性的 C 型凝集素，并且已经表明 CD207 蛋白与甘露糖的结合导致抗原内化到伯贝克颗粒中，从而提供了进入非经典抗原加工途径的途径。

Description

CD207 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 273 amino acids and having a molecular mass of 30.9kDa .
CD207 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD207 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPPRFMGTI SDVKTNVQLL KGRVDNISTL DSEIKKNSDG MEAAGVQIQM VNESLGYVRS QFLKLKTSVE KANAQIQILT RSWEEVSTLN AQIPELKSDL EKASALNTKI RALQGSLENM SKLLKRQNDI LQVVSQGWKY FKGNFYYFSL IPKTWYSAEQ FCVSRNSHLT SVTSESEQEF LYKTAGGLIY WIGLTKAGME GDWSWVDDTP FNKVQSARFW IPGEPNNAGN NEHCGNIKAP SLQAWNDAPC DKTFLFICKR PYVPSEPHHH HHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products

  • CD207 Human