标签： CD2 Human

T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, Erythrocyte receptor, Rosette receptor, CD2 antigen, CD2, T11, SRBC.

CD2 which is also known as E-rosette receptor, T11 and lymphocytefunction antigen-2 is expressed on T cells, thymocytes, and subset of natural killer cells. Human CD2 functions as the receptor for sheep erythrocytes, human CD58 , and CD15s . p56lck, p59fyn, CD3eta and CD3epsilon are tyrosine-phosphorylated after CD2 stimulation. CD2 plays a role in T cell activation, T- or NK-cell-mediated cytolysis, apoptosis in activated peripheral T cells, and regulation of T cell anergy.

CD2 也称为 E-rosette 受体、T11 和淋巴细胞功能抗原 2，在 T 细胞、胸腺细胞和自然杀伤细胞亚群上表达。 人 CD2 作为绵羊红细胞、人 CD58 和 CD15s 的受体发挥作用。 p56lck、p59fyn、CD3eta 和 CD3epsilon 在 CD2 刺激后被酪氨酸磷酸化。 CD2 在 T 细胞活化、T 或 NK 细胞介导的细胞溶解、活化的外周 T 细胞凋亡和 T 细胞无能调节中发挥作用。

CD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids and having a molecular mass of 23.8kDa.
CD2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered clear solution.

CD2 protein solution containing 20mM Tris-HCl buffer , 10% glycerol and 0.4M Urea.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85.0% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSMKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL
SAKFKCTAGN KVSKESSVEP VSCPEKGLD.

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