标签： CD-4人重组CYT-315

gp55, HLA-2, L3 / T4, Ly-4, T cell antigen T4/LEU3, T4, sCD4.

CD4, a single chain transmembrane glycoprotein, is found on a T cell subset representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. Antibody to CD4 recognizes T-helper cells required for recognition of class II antigens. It reacts with ~60% of peripheral blood E rosette-positive cells while showing negligible reactivity with E- cells, monocytes, granulocytes, EBV-transformed B cell lines, and mouse splenocytes.

CD4 是一种单链跨膜糖蛋白，存在于代表 45% 外周血淋巴细胞的 T 细胞亚群上。 它也存在于 80% 的胸腺细胞上，而单核细胞上的水平较低。 它参与由 APC 识别与 MHC II 类一起呈递的抗原。 它作为 HIV 的受体。 CD4 抗体可识别识别 II 类抗原所需的 T 辅助细胞。 它与约 60% 的外周血 E 玫瑰花结阳性细胞发生反应，而与 E 细胞、单核细胞、粒细胞、EBV 转化的 B 细胞系和小鼠脾细胞的反应性可忽略不计。

CD-4 Human Recombinant is fused with a 4kDa His Tag and encoding amino acids 125-202, having a total molecular weight of 19 kDa.

Escherichia Coli.

Sterile lyophilized powder.

Each mg contains 1X PBS.

It is recommended to reconstitute the lyophilized CD-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Store vial at -20oC to -80oC. When stored at the recommended temperature, this protein is stable for 12 months.
Please avoid freeze-thaw cycles.

Greater than 90% as determined by -PAGE.

• Protein Assay.
• Antibody Production.
• Western Blotting.

Title:Reduced Monomeric CD4 Is the Preferred Receptor for HIV.
Publication: 10.1074/jbc.M110.190579 December 24, 2010 The Journal of Biological Chemistry, 285, 40793-40799.
Link:http://www.jbc.org/content/285/52/40793.full#fn-1

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