由FMOD基因编码的纤维调蛋白是一个小间质蛋白聚糖家族的成员，它的中心区域由富含亮氨酸的重复序列组成，4个角蛋白硫酸盐链两侧有二硫键连接的末端结构域。其核心蛋白大小约为58 kDa，完全糖基化形式的分子量可达150-200 kDa。纤维调素被认为通过与I型和II型胶原连接并(负性)控制它们在体外和体内的纤维形成来参与细胞外基质的组装(这也由在FMOD缺失小鼠中观察到的胶原纤维结构的改变所证实)。纤维调素也可能通过在细胞外基质中隔离潜伏的tgf – β来影响tgf – β信号。它被认为是肿瘤间质的主要成分(特别是在上皮性肿瘤中有很好的记录)。最近的观察表明，纤维调素是慢性淋巴细胞b细胞白血病的主要预后指标。
Cosmo Bio抗体,Anti Fibromodulin (FMOD) mAb (Clone 636B12),CAC-PRPG-FBM-M01
Application: IHC, WB
Clonality: Monoclonal
Host: Mouse
Purification: Supernatant
Reactivity: Human
Fibromodulin, encoded by the FMOD gene, is a member of a family of small interstitial proteoglycans containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. Its core protein is roughly 58 kDa in size and in its fully glycosylated form reaches 150-200 kDa in molecular weight. Fibromodulin has been proposed to participate in the assembly of the extracellular matrix by linking to collagen type I and II and (negatively) controlling their fibrillogenesis in vitro and in vivo (as also confirmed by the altered collagen fibril structure observed in FMOD null mice). Fibromodulin may also influence TGF-beta signaling by sequestering latent TGF-beta in the extracellular matrix. It is recognized to be a primary component of tumor stroma (particularly well documented in epithelial tumors). Recent observations suggest that fibromodulin is a primary prognostic indicator in chronic lymphocytic B-cell leukemia.