COMP(软骨寡聚基质蛋白)是一种突出的软骨多结构域糖蛋白，占关节组织湿重的1%，Mr约为97 kDa。COMP也可在肌腱、骨(即成骨细胞)、韧带、某些平滑肌和滑膜中发现。在ECM中，COMP以五聚二硫键合物的形式存在，Mr约为550 kDa。虽然COMP的功能尚未完全阐明，但它似乎通过整合素介导软骨细胞附着，并通过与II型和IX型胶原、聚集蛋白、纤维连接蛋白和ECM蛋白1的特定阳离子依赖性相互作用稳定关节软骨ECM。此外，人类COMP基因的突变与假性软骨发育不全和多发性骨骺发育不良的发展有关，这是短肢侏儒症的常染色体显性形式。在这些患者的软骨细胞中，COMP经常被包埋在细胞内囊泡中。COMP是多种ECM降解酶的底物，包括MMP-1, MMP-13, MMP-19, MMP20和ADAMTS-4， -7和-12。COMP片段已在膝关节损伤、创伤后、原发性骨关节炎和类风湿性关节炎患者的病变软骨、滑膜液和血清中检测到，并已被提出用于退行性软骨疾病的诊断/预后。
Cosmo Bio抗体,Anti Cartilage Oligomeric Matrix Protein (COMP) mAb (Clone 490D11),CAC-PRPG-CP-M02
Application: ELISA, IHC(p), WB, ICC, IP, IHC(f)
Clonality: Monoclonal
Host: Rat
Purification: Supernatant
Reactivity: Human, Bovine
COMP – cartilage oligomeric matrix protein – is a prominent multidomain glycoprotein of cartilage, accounting for up to 1% of the wet weight of articular tissues and having an approximate Mr of 97 kDa. COMP may also be found in tendon, bone (i.e. osteoblasts), ligament, certain smooth muscles and synovium. In the ECM COMP is present in a pentameric, disulfide-bonded complex with a Mr of about 550 kDa. Although the function of COMP is not completely elucidated, it appears to mediate chondrocyte attachment via integrins and to stabilize the articular cartilage ECM via specific cation-dependent interactions with collagen types II and IX, aggrecan, fibronectin, and ECM protein 1. In addition, mutations in the human COMP gene have been linked to the development of pseudoachondroplasia and multiple epiphyseal dysplasia, which are autosomal-dominant forms of short-limb dwarfism. In chondrocytes of these patients, COMP remains frequently entrapped in intracellular vesicles. COMP is a substrate for a variety of ECM degrading enzymes, including MMP-1, MMP-13, MMP-19, MMP20 and ADAMTS-4, -7 and -12. Fragments of COMP have been detected in the diseased cartilage, synovial fluid, and serum of patients with knee injuries, post-traumatic and primary osteoarthritis and rheumatoid arthritis and have proposed to be diagnostic/prognostic of degenerative cartilage diseases.