Cosmo Bio抗体,Cosmo Bio,Anti Fish T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) mAb (Clone 2C3),CAC-NIH-NA-02
T淋巴细胞的两个主要亚群，辅助性T细胞和细胞毒性T细胞，分别由CD4和CD8糖蛋白的表达来定义。T细胞共受体CD8以CD8α多肽链的同二聚体和CD8α和CD8β链的异二聚体形式存在于成熟T细胞上。表达CD8表面抗原的T细胞在对病毒感染或转化细胞的免疫监测中是特异性效应机制的重要组成部分，因此被称为细胞毒性T淋巴细胞(ctl)。CD8+ CTL在MHC I类分子的背景下识别内源性肽。这一识别过程也涉及CD8，它与MHC Ia类分子的α3结构域结合。该抗体针对银鱼抗原，允许流式细胞术和免疫荧光分析CD8α T细胞毒细胞从斑马鱼，金鱼和鲤类鱼鲤鱼。
Anti Fish T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) mAb (Clone 2C3),CAC-NIH-NA-02
Application: FC, IHC
Clonality: Monoclonal
Host: Rat
Purification: Ig-PG
Reactivity: Goldfish, Carp, Zebrafish
The two major subsets of T lymphocytes, helper and cytotoxic T cells, are defined by expression of CD4 and CD8 glycoproteins, respectively. T cell coreceptor CD8 exists on mature T cells as homodimers of CD8α polypeptide chains and heterodimers of CD8α and CD8β chains. T cells expressing the CD8 surface antigens constitute an important component of the specific effector mechanism in immuno-surveillance against virus-infected or transformed cells and are thus termed cytotoxic T-lymphocytes (CTLs). CD8+ CTL recognize endogenously derived peptides in the context of the MHC class I molecule. This recognition process also involves CD8 which binds to the α3-domain of the MHC class Ia molecule. This antibody, raised against antigens from Ginbuna carp, permits flow cytometric and immunofluorescence analysis of CD8α T cytotoxic cells from zebrafish, goldfish and the cyprinid fish carp.